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| 1 | Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears. | Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG | 2021 | Science China(Information Sciences)2021，64，1： | 122 |
| 2 | Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors显示文摘Multipotent 神经干细胞为房间治疗保持大诺言。到导致的 pluripotent 干细胞以及成熟神经原的成纤维细胞的 reprogramming 建议可能性没有首先建立 pluripotency,把一个严重地区分的体的房间变换成一个 multipotent 状态。这里,我们证明房间从中层导出的那 Sertoli 能直接被变换成拥有神经干细胞性质的一个 multipotent 状态。导致的神经干细胞(iNSCs ) 表示多重 NSC 特定的标记,展出类似于正常 NSC 的全球基因表示侧面,并且能够自强并且区分功能的神经原进神经胶质并且 electrophysiologically。为酷氨酸 hydroxylase (TH ) 积极的导出 iNSC 的神经原污点, γ -aminobutyric 酸,和胆碱 acetyltransferase。另外, iNSCs 能熬过并且产生跟随移植进有牙齿的回转的触处。iNSCs 的产生可以为疾病建模和再生药有重要含意。 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Libin Wang Wei Li Haijiang Zhang Xiao-Yang Zhao Lei Liu Ziwei Wang Changlong Guo Hua-Jun Wu Zhonghua Liu Liu Wang Shigang He Xiu-Jie Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，1： | 31 |
| 3 | Variations of organic carbon isotopic composition and its environmental significance during the last glacial on western Chinese Loess Plateau显示文摘A high-resolution loess section in the western Chinese Loess Plateau, Yuanbao Section, was sampled for organic carbon isotopic analyses. The soil organic carbon isotope (δ13Corg) varied be- tween ?22.6‰ and ?27.5‰ during the last glacial at the section. During the last interstadial, the δ 13Corg values were more negative than those in both early and late periods of the last glacial by 4‰. The iso- topic composition indicates a coupled response of the pure C3 plants to the temperature, precipitation and the concentration of atmospheric CO2. Decrease in temperature and the atmospheric CO2 concentration from the last interstadial to Last Glaicial Maximum (LGM) caused the organic carbon isotopes to be- come positive by 1.5‰―2.0‰. The amplitude of 4‰ in the δ 13Corg variation during the last glacial should be mainly caused by the precipitation change. Therefore, the δ 13Corg variations of the Yuanbao Section during the last glacial period documented the large-amplitude fluctuation of the monsoon precipita- tion, which is estimated to be 250―310 mm more during the last interstadial than that in the LGM, and 100 mm more than that during early last glacial. The rapid changes of the monsoon precipitation on mil-lennial scale during the last glacial have also been recorded in the isotopic variations in Yuanbao loess section. As the isotopic composition varies compli- catedly as shown in the loess-paleosol sequence, it cannot be simply attributed to the abundances of C3 and C4 plants or be used as an indicator of the summer monsoon variations. | CHEN Fahu RAO Zhiguo ZHANG Jiawu JIN Ming MA Jianying | 2006 | Chinese Science Bulletin2006，51，13： | 25 |
| 4 | Formation mechanisms of megadunes and lakes in the Badain Jaran Desert,Inner Mongolia显示文摘Field observations demonstrate that calc-sinters occurred in the lakes of Badain Jaran Desert. 87Sr/86Sr ratios,14C,δ 13C and mineral com-positions of calc-sinters,and 3He/4He,4He/20Ne,δ 18O,δ D,pH and TDS of water from springs and lakes are analyzed in detail. The results indicate that the lake water is supplied through deep fault zone. The “ker-nel” of stabilized dunes in the Badain Jaran Desert perhaps consists of calc-sinters and calcareous ce-mentation layers. Deep-seated groundwater effuses from this “kernel” and recharges to lakes in desert. Precipitation and snowmelt water from the Qing-hai-Tibet Plateau is fed into the Badain Jaran Desert,Gurinai,Wentougaole and Ejinqi areas through the Xigaze-Langshan Fault zone. The isotopic composi-tions of groundwater in the Alax Plateau are abnor-mal due to the strong evaporation of the Gyaring and Ngoring lake water in the headstream of the Yellow River. Groundwater dissolves dissoluble fractions of rocks during its transportation through the fault zone and flows out of the mouth of spring in the Badan Jaran Desert. The dissoluble fractions are finally de-veloped into calc-sinters and calcareous cementation layers around the spring. Calci-sinters are gradually largened and eventually emerge on the surface of lake water. Eolian sands accumulate on the surfaces of calc-sinters and calcareous cementation layers,and eventually develop into dunes. Invasion of magma causes an increase in the temperature of groundwater within the faults. Groundwater evapora-tion provides water vapor for the formation of humid stabilized dunes during its upwelling. Rhizoconcre-tions found in Yihejigede indicate that the dune was formed and remained immovable 4700 years ago. The height of the megadunes is proportional to thermal quantity carried by the groundwater. | CHEN Jiansheng ZHAO Xia SHENG Xuefen DONG Haizhou RAO Wenbo SU Zhiguo | 2006 | Chinese Science Bulletin2006，51，24： | 19 |
| 5 | On the timing of the East Asian summer monsoon maximum during the Holocene Does the speleothem oxygen isotope record reflect monsoon rainfall variability?显示文摘The evolution of the East Asian summer monsoon(EASM) during the Holocene has long been of significant interest.Knowledge of past EASM variability not only increases our understanding of monsoon dynamics on a long timescale,but it also provides an environmental and climatic background for research into Chinese cultural development.However,the timing of the EASM maximum remains controversial.The popular concept of an 'early Holocene maximum' is mainly based on speleothemδ^(18)O(δ^(18)O_c) records from caves in southern China;however,the interpretation of δ^(18)O_C as a reliable proxy for EASM intensity is being increasingly challenged.The present paper is a critical review of the climatic significance of the δ^(18)O_C record from China.Firstly,we suggest that precipitation in northern China is an appropriate index of EASM intensity,the variation of which clearly indicates a mid-Holocene monsoon maximum.Secondly,an interregional comparison demonstrates that the precipitation record in northern China is quite different from that in southern China on a range of timescales,and is inconsistent with the spatial similarity exhibited by speleothem oxygen isotope records.Furthermore,both modeling and observational data show that the δ^(18)O_C records from southern China indeed reflect changes in precipitation δ^(18)O(δ^(18)O_P) rather than precipitation amount,and therefore that their use as an EASM proxy is inappropriate.Finally,we address several significant monsoon-related issues-including the driving mechanism of the EASM on an orbital timescale,the climatic significance of speleothem oxygen isotopes,and the relationship between atmospheric circulation and precipitation in monsoonal regions. | CHEN JianHui RAO ZhiGuo LIU JianBao HUANG Wei FENG Song DONG GuangHui HU Yu XU QingHai CHEN FaHu | 2016 | Science China(Information Sciences)2016，59，12： | 18 |
| 6 | Xuebijing injection alleviates liver injury by inhibiting secretory function of Kupffer cells in heat stroke rats显示文摘OBJECTIVE:To evaluate the effects of Xuebijing(XBJ) injection in heat stroke(HS) rats and to investigate the mechanisms underlying these effects.METHODS:Sixty anesthetized rats were randomized into three groups and intravenously injected twice daily for 3 days with 4 mL XBJ(XBJ group) or phosphate buffered saline(HS and Sham groups) per kg body weight.HS was initiated in the HS and XBJ groups by placing rats in a simulated climate chamber(ambient temperature 40 ℃,humidity 60%).Rectal temperature,aterial pressure,and heart rate were monitored and recorded.Time to HS onset and survival were determined,and serum concentrations of tumor necrosis factor(TNF)-α,inRESULTS:Time to HS onset and survival were significantly longer in the XBJ than in the HS group.Moreover,the concentrations of TNF-α,IL-1β,IL-6,ALT and AST were lower and liver injury was milder in the XBJ than in the HS group.Heat-stress induced structural changes in KCs and hepatic cells were more severe in the HS than in the XBJ group and the concentrations of TNF-α,IL-β and IL-6 secreted by KCs were lower in the XBJ than in the HS group.CONCLUSION:XBJ can alleviate HS-induced systemic inflammatory response syndrome and liver injury in rats,and improve outcomes.These protective effects may be due to the ability of XBJ to inhibit cytokine secretion by KCs. | Yi Chen Huasheng Tong Xingqin Zhang Liqun Tang Zhiguo Pan Zhifeng Liu Pengkai Duan Lei Su | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 14 |
| 7 | Occurrence and distribution of antibiotic resistance genes in the sediments of the East China Sea bays显示文摘The coastal area of the East China Sea has experienced rapid urbanization and industrialization in China since 1980 s, resulting in severe pollution of its environments.Antibiotic resistance genes(ARGs) are regarded as a kind of emerging pollutant with potential high risk. The sediment samples were collected from Hangzhou Bay(HB),Xiangshan Bay(XB), and Taizhou Bay(TB) to investigate the spatial occurrence and distribution of 27 ARGs and class I integron–integrase gene(intI1) in the coastal area of the East China Sea. The PCR results showed the frequent presence of 11 ARGs and intI1 in the sediments of the three bays. The qPCR results further showed that sulfonamide resistance was the most prevalent ARG type and antibiotic target replacement and protection were the most important resistance mechanisms in the sediments. Regarding the subtype of ARGs, sulI, tetW, and dfrA13 were the most abundant ARGs, in which sulI was higher in TB(based on both the absolute and relative abundances) and dfrA13 was higher in HB(based on the relative abundances). The network analysis revealed that intI1 had significant correlations with tetC, sulI, sulII, and blaPSE-1. Oil was the key connected factor, which had positive connections with sulI, sulII, and blaPSE-1. In addition, the joint effect of heavy metals and nutrients & organic pollutants might be crucial for the fate of ARGs in the coastal sediments. | Jiayu Chen Zhiguo Su Tianjiao Dai Bei Huang Qinglin Mu Yongming Zhang Donghui Wen | 2019 | Journal of Environmental Sciences2019，31，7： | 13 |
| 8 | Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors显示文摘 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Lisi Sang Libin Wang Changlong Guo Wanwan Zhu Man Tong Lei Liu Wei Li Zhong-Hua Liu Xiao-Yang Zhao Liu Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，4： | 12 |
| 9 | Geologic investigation and mapping of the Sinus Iridum quadrangle from Clementine, SELENE, and Chang’e-1 data显示文摘The objectives of lunar satellite remote sensing are to study lunar surface characteristics, inner structure, and its evolution history. The contents of TiO 2 and FeO are assessed from Clementine UV/VIS data for Sinus Iridum. The geologic stratigraphic units and crates are interpreted visually based on SELENE Terrain Camera (TC) images and the spatial resolution of which is up to 10 m. And the geologic ages of different stratigraphic units are calculated by the crater size-frequency distributions measurements. The gravity anomaly is generated from SELENE gravity model (SGM90d) to show its difference from Mare Imbrium. Furthermore, the thickness of lunar regolith is also derived from microwave radiometer data of Chang’e-1 satellite. Integrating these results, it shows that the Sinus Iridum is different from the Mare Imbrium in inner structure and surface sedimentation. And its history of subsidence, deposition, volcanism, and impact is described. It makes sense to the future soft-landing and sampling at potential Sinus Iridum by remote sensing geologic analysis. | CHEN ShengBo , MENG ZhiGuo, CUI TengFei, LIAN Yi, WANG JingRan & ZHANG XuQing College of Geoexploration Science and Technology, Jilin University, Changchun 130026, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，12： | 10 |
| 10 | Chemical and Isotopic Approach to Groundwater Cycle in Western Qaidam Basin,China显示文摘Due to the extremely arid climate in the western Qaidam Basin,the groundwater almost becomes the single water source for local residents and industrial production.It is necessary to know the reliable information on the groundwater cycle in this region for reasonable and sustainable exploitation of the groundwater resources with the further execution of recycling economy policies.This study focused on the recharge,the flow rate and the discharge of groundwater in the western Qaidam Basin through investigations on water chemistry and isotopes.Hydrological,chemical and isotopic characteristics show that the groundwater in the western Qaidam Basin was recharged by meltwater from new surface snow and old bottom glaciers on the northern slope of the Kunlun Mountains.In addition,the results also prove that the source water is enough and stable,and the rates of the circulation and renewal of the groundwater are relatively quick.Therefore,it can be concluded that the groundwater resources would guarantee the regional requirement if the meltwater volume of the mountains has not a great changes in future,moreover,water exploitation should be limited to the renewable amount of the groundwater reservoir in the western Qaidam Basin. | TAN Hongbing RAO Wenbo CHEN Jiansheng SU Zhiguo SUN Xiaoxu LIU Xiaoyan | 2009 | Chinese Geographical Science2009，19，4： | 10 |
| 11 | Pollution characteristics and ecological risk of polycyclic aromatic hydrocarbons (PAHs) in surface sediments of the southern part of the Haihe River system in China显示文摘The southern part of the Haihe River system, the largest river system in the Haihe River Basin, is important to maintain a healthy ecosystem and safe drinking water as well as for the economic development of China. To assess the effect of rapid industrialization and urbanization on the pattern of polycyclic aromatic hydrocarbon (PAH) contamination, the PAH pollution characteristics of the southern part of the Haihe River system was investigated. Sixteen PAHs in surface sediments samples collected from 24 sites covering the southern part of the Haihe River system from the upstream to the estuaries were detected and analyzed. The total PAH concentration ranged from 258.77 to 11296.66 ng/g dry weight. On average, 2-, 3-, 4-, 5and 6-ring PAHs comprised 25.32%, 27.22%, 22.62%, 14.89% and 9.96% of the total PAHs, respectively. Sites with high concentrations were concentrated in the Fuhe River, Fuyang River and Wei River, which are located near cities. A risk quotient (RQ) was used to assess the ecological risk of PAHs. The mean values of the RQ(MPCs) of individual PAHs were lower than 1.00, except for those of naphthalene (2.00) and pyrene (1.67). The RQPAHs calculated for the samples indicated that the Xidayang reservoir and the estuary of the Ziya River were determined to be at a low risk level, while Baoding City, Handan City and Aixinzhuang were determined to be at a high risk level. | LIU Feng LIU JingLing CHEN QiuYing WANG BinBin CAO ZhiGuo | 2013 | Chinese Science Bulletin2013，58，27： | 9 |
| 12 | Construction of China Osmanthus City and Intellectual Property Right Protection in Xianning City in the Context of Three New Developments显示文摘Xianning City of Hubei Province is one of the five major traditional osmanthus producing areas in the world and the hometown of osmanthus in China. Xianning is constructing China Osmanthus City in the whole city. This paper first introduces the main characteristics of the osmanthus industry in Xianning City, and analyzes the characteristics of traditional knowledge, biological genetic resources, new plant varieties, patents, geographical indications, and trademarks. Then, it studies the intellectual property resources of the osmanthus industry, and analyzes the main problems existing in the construction of China Osmanthus City and intellectual property right protection. Finally, it comes up with constructive recommendations including applying for China and Globally Important Agricultural Heritage Systems, developing colored-leaf osmanthus varieties, creating a regional public brand of osmanthus specialty products, and building a new development pattern of osmanthus industry. | Li GAO Zhiguo SUN Yueqiu HE Jiandong LAI Hongguo CHEN | 2022 | Asian Agricultural Research2022，14，9： | 9 |
| 13 | Using PoF models to predict system reliability considering failure collaboration显示文摘Existing Physics-of-Failure-based(PoF-based) system reliability prediction methods are grounded on the independence assumption, which overlooks the dependency among the components. In this paper, a new type of dependency, referred to as failure collaboration, is introduced and considered in reliability predictions. A Po F-based model is developed to describe the failure behavior of systems subject to failure collaboration. Based on the developed model, the Bisection-based Reliability Analysis Method(BRAM) is exploited to calculate the system reliability. The developed methods are applied to predicting the reliability of a Hydraulic Servo Actuator(HSA). The results demonstrate that the developed methods outperform the traditional Po F-based reliability prediction methods when applied to systems subject to failure collaboration. | Zeng Zhiguo Kang Rui Chen Yunxia | 2016 | Chinese Journal of Aeronautics2016，29，5： | 8 |
| 14 | Detection of Salmonella and several common Salmonella serotypes in food by loop-mediated isothermal amplification method显示文摘Salmonella Choleraesuis,S.Enteritidis and S.Typhimurium are the main pathogens that contaminate animal products and cause human Salmonella food poisoning.To establish the loop-mediated isothermal amplification(LAMP)method for the rapid detection of Salmonella and 3 common Salmonella serotypes,inner and outer primer sets targeting Salmonella invE gene and 3 serotype-specific genes fliC,lygD and STM4495 were designed.The LAMP reaction conditions were optimized.The specificity of LAMP primers was identified by testing 10 different bacterial strains including S.Choleraesuis,S.Enteritidis and S.Typhimurium.Take S.Choleraesuis as example,the detection limit of LAMP assay was 1.33×10^1 CFU/mL for bacteria culture and 2.0×10^1 CFU/mL for simulated pork sample.The results show that LAMP is a rapid,sensitive and specific method for Salmonella detection and can be used for the rapid detection of Salmonella in food. | Zhongqiang Chen Ke Zhang Huan Yin Qi Li Lan Wang Zhiguo Liu | 2015 | Food Science and Human Wellness2015，4，2： | 8 |
| 15 | Brain-derived neurotrophic factor induces neuron-like cellular differentiation of mesenchymal stem cells derived from human umbilical cord blood cells in vitro显示文摘Human umbilical cord blood was collected from full-term deliveries scheduled for cesarean section.Mononuclear cells were isolated,amplified and induced as mesenchymal stem cells.Isolated mesenchymal stem cells tested positive for the marker CD29,CD44 and CD105 and negative for typical hematopoietic and endothelial markers.Following treatment with neural induction medium containing brain-derived neurotrophic factor for 7 days,the adherent cells exhibited neuron-like cellular morphology.Immunohistochemical staining and reverse transcription-PCR revealed that the induced mesenchymal stem cells expressed the markers for neuron-specific enolase and neurofilament.The results demonstrated that human umbilical cord blood-derived mesenchymal stem cells can differentiate into neuron-like cells induced by brain-derived neurotrophic factor in vitro. | Lei Chen Zhongguo Zhang Bing Chen Xiaozhi Liu Zhenlin Liu Hongliang Liu Gang Li Zhiguo Su Junfei Wang Guozhen Hui | 2011 | Neural Regeneration Research2011，6，13： | 8 |
| 16 | Preliminary analysis of spatiotemporal pattern of global land surface water显示文摘Land surface water(LSW) is one of the most important resources for human survival and development, and it is also a main component of global water recycling. A full understanding of the spatial distribution of land surface water and a continuous measuring of its dynamics can support to diagnose the global ecosystem and environment. Based on the Global Land 30-water 2000 and Global Land 30-water 2010 products, this research analyzed the spatial distribution pattern and temporal fluctuation of land surface water under scale-levels of global, latitude and longitude, continents, and climate zones. The Global Land 30-water products were corrected the temporal inconsistency of original remotely sensed data using MODIS time-series data, and then calculated the indices such as water area, water ration and coefficient of spatial variation for further analysis. Results show that total water area of land surface is about 3.68 million km2(2010), and occupies 2.73% of land area. The spatial distribution of land surface water is extremely uneven and is gathered mainly in mid- to high-latitude area of the Northern Hemisphere and tropic area. The comparison of water ratio between 2000 and 2010 indicates the overall fluctuation is small but spatially differentiated. The Global Land 30-water products and the statistics provided the fundamental information for analyzing the spatial distribution pattern and temporal fluctuation of land surface water and diagnosing the global ecosystem and environment. | CAO Xin CHEN Jun CHEN LiJun LIAO AnPing SUN FangDi LI Yang LI Lei LIN ZhongHui PANG ZhiGuo CHEN Jin HE ChaoYing PENG Shu | 2014 | Science China Earth Sciences2014，57，10： | 8 |
| 17 | Effect of N fertilization rate on soil alkalihydrolyzable N, subtending leaf N concentration,fiber yield, and quality of cotton显示文摘Soil alkali-hydrolyzable nitrogen, which is sensitive to N fertilization rate, is one of the indicators of soil nitrogen supplying capacity. Two field experiments were conducted in Dongtai(120°19″ E, 32°52″ N), Jiangsu, China in 2009 and Dafeng(120°28″ E, 33°12″ N), Jiangsu province, China in 2010. Six nitrogen rates(0, 150, 300, 375, 450, and 600 kg ha^(-1)) were used to study the effect of N fertilization rate on soil alkali-hydrolyzable nitrogen content(SAHNC), subtending leaf nitrogen concentration(SLNC), yield, and fiber quality. In both Dongtai and Dafeng experiment station, the highest yield(1709 kg ha^(-1)), best quality(fiber length 30.6 mm, fiber strength 31.6 c N tex^(-1), micronaire 4.82), and highest N agronomic efficiency(2.03 kg kg^(-1)) were achieved at the nitrogen fertilization rate of 375 kg ha^(-1). The dynamics of SAHNC and SLNC could be simulated with a cubic and an exponential function,respectively. The changes in SAHNC were consistent with the changes in SLNC. Optimal average rate(0.276 mg day^(-1)) and duration(51.8 days) of SAHNC rapid decline were similar to the values obtained at the nitrogen rate of 375 kg ha^(-1)at which cotton showed highest fiber yield, quality, and N agronomic efficiency. Thus, the levels and strategies of nitrogen fertilization can affect SAHNC dynamics. The N fertilization rate that optimizes soil alkali-hydrolyzable nitrogen content would optimize the subtending leaf nitrogen concentration and thereby increase the yield and quality of the cotton fiber. | Binglin Chen Hongkun Yang Weichao Song Chunyu Liu Jiao Xu Wenqing Zhao Zhiguo Zhou | 2016 | The Crop Journal2016，4，4： | 8 |
| 18 | In vitro effect of iASPP on cell growth of oral tongue squamous cell carcinoma显示文摘iASPP is an inhibitory member of the apoptosis-stimulating proteins of P53(ASPP) family. iASPP is over expressed in several malignant tumors and potentially affects cancer progression. However, the expression and potential role of iASPP in oral tongue squamous cell carcinoma(OTSCC) have not been addressed. In our study, we detected iASPP expression in OTSCC by immunohistochemistry. iASPP expression is up-regulated in OTSCC tissues. Moreover, in clinical pathology specimens, we found that increased iASPP expression correlates with poor differentiation and lymph node metastasis. Using multicellular tumor spheroids(MTS) and flow cytometry, we demonstrated that iASPP down-regulation arrests OTSCC cells at the G0/G1 phase, induces OTSCC cell apoptosis and inhibits OTSCC cell proliferation. These results indicate that iASPP plays a significant role in the progression of OTSCC and may serve as a biomarker or therapeutic target for OTSCC patients. | Yu Chen Wangxiang Yan Shuqi He Jiechun Chen Dan Chen Zhaoqiang Zhang Zhiguo Liu Xueqiang Ding Anxun Wang | 2014 | Chinese Journal of Cancer Research2014，26，4： | 7 |
| 19 | Relationship between climatic conditions and the relative abundance of modern C_3 and C_4 plants in three regions around the North Pacific显示文摘Using -24‰ and -14‰ as the endpoints of stable carbon isotopic composition of total organic carbon (δ 13CTOC) of surface soil under pure C3 and C4 vegetation, and surface soil δ 13CTOC data from eastern China, Australia and the Great Plains of North America, we estimate the relative abundance of C3/C4 plants (i.e., the ratio of C3 or C4 biomass to local primary production) in modern vegetation for each region. The relative abundance of modern C3/C4 vegetation from each region is compared to the corresponding climatic parameters (mean annual temperature and precipitation) to explore the relationship between relative C4 abundance and climate. The results indicate that temperature controls the growth of C4 plants. However, even where temperature is high enough for the growth of C4 plants, they will only dominate the landscape when precipitation declines as temperatures increase. Our results are consistent with those of other investigations of the geographic distribution of modern C4 plant species. Therefore, our results provide an important reference for interpretation of past C3/C4 relative abundance records in these three regions. | RAO ZhiGuo ZHU ZhaoYu JIA GuoDong CHEN FaHu BARTON Loukas ZHANG JiaWu QIANG MingRui | 2010 | Chinese Science Bulletin2010，55，18： | 7 |
| 20 | Establishment of a transgenic mouse model with liver-specific expression of secretory immunoglobulin D显示文摘Mutation of mevalonate kinase(MVK) is thought to account for most cases of hyperimmunoglobulinemia D syndrome(HIDS) with recurrent fever.However,its mechanism and the relationship between elevated serum immunoglobulin D(IgD) and the clinical features of HIDS are unclear.In this study,we generated by fusion PCR a vector to express high levels of chimeric secretory IgD(csIgD) specifically in the liver.We then generated seven founder lines of transgenic mice by co-microinjection,and verified them using genomic PCR and Southern blotting.We detected the expression of csIgD by reverse transcription PCR,quantitative PCR,western blotting,and enzyme-linked immunosorbent assays.We demonstrated that csIgD could be specifically and stably expressed in the liver.We used flow cytometry to show that overexpression of csIgD in the bone marrow and spleen cells had no effect on B cell development.Morphologic and anatomical observation of the transgenic mice revealed skin damage,hepatosplenomegaly,and nephromegaly in some transgenic mice;in these mice,pathological sections showed high levels of cell necrosis and protein-like sediments in the liver,spleen,and kidney.We demonstrated that the genomic insertion sites of the transgenes did not disrupt the MVK gene on mouse chromosome 5.This transgenic mouse will be useful to explore the pathogenesis of HIDS. | WANG Ping WEI ZhiGuo YAN BoWen HUANG Tan GOU KeMian DAI YunPing ZHENG Min WANG MeiLi CHENG XueQian WANG XiFeng XU Chen SUN Yi | 2012 | Science China(Life Sciences)2012，55，3： | 6 |
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