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| 1 | Portal vein thrombosis in cirrhotic patients-it is always the small pieces that make the big picture显示文摘Portal vein thrombosis(PVT) is a frequent and serious complication in patients with liver cirrhosis(LC). Recently, a new classification of PVT was proposed, although the functional component was not completed included. The status of liver disease(compensated/decompensated) should be added to this classification. Reduced portal flow velocity and the acquired hypercoagulable status associated with LC are the main risk factors for PVT development, although endothelial dysfunction may play an important role that needs to be further evaluated. The European Association for the Study of the Liver and the American Association for the Study of Liver Disease recommend that the anticoagulant treatment should be consider in cirrhotic patients with PVT. Low molecular weight heparin and vitamin K antagonists proved their efficacy and relatively safety in PVT treatment, although in addition to recanalization rates, more complex endpoints such as mortality and decompensation rate should be evaluated. The new oral anticoagulant therapies offers the advantage of oral administration in the absence of laboratory monitoring, however, there are a few reports regarding their use in cirrhotic patients, most of them referring to compensated isolated cases. Transjugular intrahepatic portosystemic shunt could be an alternative if thrombosis progresses despite anticoagulatant therapy and/or when PVT is associated with portal hypertension complications. The aim of this editorial is to discuss the different aspects of pathophysiology, clinical relevance, diagnosis and management of PVT in patients with LC. | Irina Girleanu Anca Trifan Carol Stanciu Cǎtǎlin Sfarti | 2018 | World Journal of Gastroenterology2018，24，39： | 6 |
| 2 | Advances in Understanding Seed Dormancy at the Whole-seed Level: An Ecological, Biogeographical and Phylogenetic Perspective显示文摘Following a brief account of the early foundations of seed germination ecology sensu lato, some historical and recent developments pertaining to the ecology, biogeography and phylogeny of seed dormancy are discussed. | BASKIN Carol C BASKIN Jerry M | 2008 | 云南植物研究2008，30，3： | 3 |
| 3 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 4 | 临床实践指南应当包含治疗负担显示文摘医疗方案的实施需要花费大量时间和精力,给慢性病患者带来巨大负担。然而,临床实践指南高度重视的是得到某些临床结果(如呼吸急促减少或存活率增加),传统指南的建议也是从同样角度提出的。最近的指南会考虑患者的价值观以及指南建议行为的可接受性和可行性,但对治疗负担没有明确规定。这使患者很难根据自己的价值观和能力对治疗做出明智的决定。 | Claudia C Dobler Nathan Harb Catherine A Maguire Carol L Armour Courtney Coleman M Hassan Murad 邓璇(译) 莫云凌(校) | 2019 | 英国医学杂志中文版2019，22，3： | 3 |
| 5 | 用心脏的磁性的回声成像部分 1: 的心肌症的调查普通显型显示文摘 Cardiac magnetic resonance imaging(CMRI) has emerged as a useful tertiary imaging tool in the investigation of patients suspected of many different types of cardiomyopathies,CMRI sequences are now of a sufficiently robust quality to enable high spatial and temporal resolution image acquisition.This has led to CMRI becoming an effective non-invasive imaging gold standard for many cardiomyopathies.In this 2-part review,we outline the typical sequences used to image cardiomyopathy,and present the imaging spectrum of cardiomyopathy.Part 1 focuses on the current classification of cardiomyopathy,basic CMRI sequences used in evaluating cardiomyopathy and the imaging spectrum of common phenotypes. | Shaunagh McDermott Ailbhe C O’Neill Carole A Ridge Jonathan D Dodd | 2012 | World Journal of Cardiology2012，4，4： | 2 |
| 6 | The intracellular production and secetion of HIV-1 envelope protein in the methylotrophic yeast Pichia pastoris 显示文摘 | Carol A S Richard G B Jeffrey J C | 1993 | Gene1993，136，： | 2 |
| 7 | Geometric damage tensor based on microplane model 显示文摘 | Carol I BaZant Z E Prat P C | 1991 | Journal of Engineering Mechanics1991，117，10： | 1 |
| 8 | A Statistical Method for Predicting Automobile Driving Posture显示文摘 | Reed Matthew R Manary Miriam A Flannagan Carol A C | | 0，，04： | 1 |
| 9 | A Classroom Investigation: Can Video Improve Intermediate-Level French Language Students' Ability to Learn about a Foreign Culture? 显示文摘 | Carol H C Debastien D Steven C | 2002 | Modern Language Journal2002，，2： | 1 |
| 10 | New explicit microplane model for concrete: Theoretical aspects and numerical implementation 显示文摘 | Carol I Prat P C Bazant Z P | 1992 | International Journal of Solids and Structures1992，29，9： | 1 |
| 11 | The callipyge mutation enhances the expression of coregulated imprinted genes in cis without affecting their imprinting status显示文摘 | Carole C Karin S Latifa K | 2001 | Nature Genetics2001，27，： | 1 |
| 12 | Comparison between different LiFePO4 synthesis routes and their influence on its physico-chemical properties显示文摘 | SLVSIN F FREDEREC L C CAROLE B HELENE R | 2003 | J Power Source2003，，： | 1 |
| 13 | Current Practices in Sedation and Analgesia for Mechanically Ventilated Critically Ill Patients: A Prospective Multicenter Patient-based Study显示文摘 | Jean-Francois Payen Gérald Chanques Jean Mantz Christiane Hercule Igor Auriant Jean-Luc Leguillou Michèle Binhas Céline Genty Carole Rolland Jean-Luc Bosson | 2007 | Anesthesiology2007，，4： | 1 |
| 14 | Canopy transpiration using time series analysis: A case study illustrating the effect of soil moisture deficit on Pinus taeda 显示文摘 | Ford C R Carol E G Robert J M | 2005 | Journal of Agricultural and Forest Meteorology2005，130，： | 1 |
| 15 | The callipyge locus:evidence for the trans interaction of reciprocally imprinted genes显示文摘 | Miche G Carole c Noelle C | 2003 | Trends in Genetics2003，19，5： | 1 |
| 16 | Combined effects ofnutr ents and temperature on the production of fermentative aromas by Sat charomyces cerevisiae during wine fermentation 显示文摘 | ROLLERO S BLOEM A CAROLE C | 2015 | Appl Mierobi Biotechnol2015，99，5： | 1 |
| 17 | Silica in plants: biological,biochemical and chemical studies显示文摘 | HEATHER A C CAROLE C P | 2007 | Annals of Botany2007，100，7： | 1 |
| 18 | 显示文摘 | MARTIN C CAROL A E RENEE A E Effects of Irradiance on Crassulacean Acid Metabolism in the Epiphyte Tillandsia usneoides L | 1986 | Plant Physiol1986，80，： | 1 |
| 19 | Postoperative rehabilitation protocols for Achilles tendon rupture: a Meta-analysis显示文摘 | AMAR A S CAROL S DAVID C R | 2006 | Clinical Orthopedics and Related Research2006，445，： | 1 |
| 20 | Mutations in the Arabidopsis gene IMMUTANS cause a variegated phenotype by inactivating a chloroplast terminal oxidase associated with phytoene desaturation 显示文摘 | Carol P Stevenson D Bisanz C | 1999 | The Plant Cell1999，11，： | 1 |
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