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| 1 | 转基因大麦中gfp基因的染色体位置及其表达(英文)显示文摘通过对大麦小孢子进行基因枪轰击获得 4株转绿色荧光蛋白基因 (gfp)的植株 (A、C、D、E) ,以gfp基因为探针进行荧光原位杂交 (FISH)研究转化植株中转基因插入位置和基因表达。 4个株系在染色体 7L(5HL)的不同位置都有一个插入点 ,而E株系在染色体 5S(7HS)还有第 2个插入点。所有的转基因T0 代植株都是半合子并在T1、T2代发生分离。D株系GFP未表达 ,但FISH和PCR分析表明gfp基因已成功插入其染色体。各株系在根尖和花粉中的GFP表达水平不同 :C株系在花粉表达强而在根尖表达中等 ;A株系在花粉中等表达而在根尖表达较淡 ;E株系则在根尖高表达 ,花粉中等表达。A和C株系在根尖和花粉的GFP分离都表现单位点特性 ,而E株系的根尖分离表现重叠作用 (15∶1)特征 ,但在花粉中表达GFP的频率低。PCR结果和 3个分离株系的根尖表达结果一致。D和E株系的GFP表达不正常可能和gfp基因插入位置或基因的结构有关。 | 陈建民 Carlson A R 万建民 Kasha K J | 2003 | Acta Genetica Sinica2003，30，8： | 6 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | Effect of river landscape on the sediment concentrations of antibiotics and corresponding antibiotic resistance genes(ARG)显示文摘 | PEI R KIM S C CARLSON K H PRUDEN A | 2006 | Water Res2006，40，12： | 1 |
| 4 | A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression 显示文摘 | Zarate C A Singh J B Carlson P J | 2006 | Arch Gen Psychiatry2006，63，： | 1 |
| 5 | RH-5849, a nonsteroidal ecdysone agonist: effects on larval lepidoptera 显示文摘 | K D Wing R A Slawecki G R Carlson | 1988 | Science1988，241，： | 1 |
| 6 | Evidence that physiLologic levels of circulating estrogens and neonatal sex-imprinting modify postpubertal hepatic microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase acivity显示文摘 | Carlson S E Mitchell A D Carter M L | 1980 | Biochem Biophys Acta1980，633，： | 1 |
| 7 | Variability of apatite fission track annealing kinetics III: extrapolation to geological time scales 显示文摘 | Ketcham R A Donelick R A Carlson W D | 1999 | American Mineralogist1999，84，9： | 1 |
| 8 | Biochemical and molecular characterization of a mutation that confers a decreased raffinosaccharide and phytic acid phenotype on soybean seeds 显示文摘 | Hize W D Carlson T J Kerr P S Sebastian S A | 2002 | Plant Physiology2002，128，： | 1 |
| 9 | On the relation between NDVI, fractional vegetation cover, and leaf area index 显示文摘 | Carlson T N Ripley D A | 1997 | Remote Sensing of Environment1997，62，03： | 1 |
| 10 | Federated Kalman Filter Sim- ulation Results显示文摘 | Carlson N A Berarduccl M P | 1994 | Navigation1994，28，3： | 1 |
| 11 | Shear-en- hanced adhesiveless transfer printing for use in deterministic materials assembly 显示文摘 | CARLSON A KIM-LEE H J WU Jian | 2011 | Applied Physics Letters2011，98，26： | 1 |
| 12 | Development of new feeding-distance rules using casting simulation: part II, the new rules 显示文摘 | Ou S Carlson K D Hardin R A | 2002 | Metallurgical and Materials Transactions B2002，33，： | 1 |
| 13 | The SAVE approach to component-based development of vehicular systems显示文摘 | Mikael A kerholm Jan Carlson Johan Fredriksson | 2007 | Journal of Systems and Software2007，80，5： | 1 |
| 14 | Viscoelastic properties of magneto-and electro-rheological fluids显示文摘 | CARLSON J D NIXON D A | 1994 | Journal of Intelligent Material Systems and Structure1994，，5： | 1 |
| 15 | Physical activity and the risk of dementia in oldest old 显示文摘 | Sumic A Michael YL Carlson NE | 2007 | J Aging Health2007，19，2： | 1 |
| 16 | Promotion of the release of 11-cis-retinal from cultured retinal pigment epithelium by interphotoreceptor retinoid-binding protein 显示文摘 | Carlson A Bok D | 1992 | Biochemistry1992，31，37： | 1 |
| 17 | Oceanic bacterial production显示文摘 | Ducklow H W Carlson C A | 1992 | Advances in Microbial Ecology1992，，12： | 1 |
| 18 | Characterization of vitellogenin from white sturgeon Acipenser transmontanus 显示文摘 | BidweU C A Carlson D M | 1995 | Mol Evol1995，41，1： | 1 |
| 19 | Alter-ation in the hypothalamic-pituitary-ovarian axis in depressed women显示文摘 | YOUNG E A MIDGLEY A R CARLSON N E | 2000 | Arch Gen Psychiatry2000，57，12： | 1 |
| 20 | Capture time, size and hookingmortality of bottom longline-caught sharks 显示文摘 | MORGAN A CARLSON J K | 2010 | FisheriesResearch2010，101，12： | 1 |
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