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| 1 | Structure and function of aggrecan显示文摘Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the cartilage with load-bearing properties. It is also crucial in chondroskeletal morphogenesis during development. Aggrecan is a multimodular molecule expressed by chondrocytes. Its core protein is composed of three globular domains (G1, G2, and G3) and a large extended region (CS) between G2 and G3 for glycosaminoglycan chain attachment. G1 comprises the amino terminus of the core protein. This domain has the same structural motif as link protein. Functionally, the G1 domain interacts with hyaluronan acid and link protein, forming stable ternary complexes in the extracellular matrix. G2 is homologous to the tandem repeats of G1 and of link protein and is involved in product processing. G3 makes up the carboxyl terminus of the core protein. It enhances glycosaminoglycan modification and product secretion. Aggrecan plays an important role in mediating chondrocyte-chondrocyte and chondrocyte-matrix interactions through its ability to bind hyaluronan. | CHRIS KIANI, LIWEN CHEN, YAO JIONG WU, ALBERT J YEE, BURTON B YANG, Sunnybrook and Women’s College Health Sciences Centre and Department of Laboratory Medicine and Patobiology, 2 Department of Surgeny, Faculty of Medicine, University of Toronto, Canada | 2002 | Cell Research2002，12，1： | 27 |
| 2 | Analyzing and Comparing Montgomery Multiplication Algorithms显示文摘 | Koc C K Acar T Burton S | 1996 | IEEE Micro1996，16，3： | 1 |
| 3 | Computational models for sandwich panels and shells显示文摘 | Noor A K Burton W S Bert C W | 1996 | Applied Mechanics Reviews1996，4，3： | 1 |
| 4 | Effects of hydrothermal aging on NH3 -SCR reaction over Cu/zeolites 显示文摘 | Kwak J H Tran D Burton S D | 2012 | Journal of Catalysis2012，287，： | 1 |
| 5 | Relationships between fine root dynamics and nitrogen availability in Michigan northern hardwood forests 显示文摘 | Burton A J Pregitzer K S Hendrick R L | 2000 | Oecologia2000，125，3： | 1 |
| 6 | Velocity and Temperature Mea- surements in a Low-power Hydrazine Arejet 显示文摘 | Burton S A Burton R L | 1997 | Journal of Propulsion and Power1997，13，6： | 1 |
| 7 | Prediction of core saturation instability at an HVDC converter显示文摘 | Burton R S Fuchshuber C Woodford DA | 1996 | IEEE Trans on Power Delivery1996，11，4： | 1 |
| 8 | Synthesis of quinoxaline, benzimidazole, and alkoxybenzene derivatives containing a novoldiamine moiety显示文摘 | Yan S J Burton W H Chien Ping-Lu | 1978 | Journal of Heterocyclic Chemistry1978，15，2： | 1 |
| 9 | In vitro eytocidal effect of novel lyric peptides on plasmodium faleiparum and trypanosom a cruzfi显示文摘 | JAYNES J M BURTON C A BARR S B | 1989 | The FASEB Journal1989，2，12： | 1 |
| 10 | Two-dimensional phase unwrapping using a hybrid genetic algorithm 显示文摘 | Karout S Gdeisat M Burton D | 2007 | AppLied Optics2007，46，5： | 1 |
| 11 | Genetic diversity and species identification in the endangered white abalone (Haliotis sorenseni ) 显示文摘 | Gruenthal K M Burton R S | 2005 | Conservation Genetics2005，6，： | 1 |
| 12 | Exploring depthversus breadth in knowledge management strategies 显示文摘 | TURNER S F BETTIS R A BURTON R M | 2002 | Com-putational and Mathematical Organization Theory2002，8，1： | 1 |
| 13 | Radiosurgery for spinal metastases: clinical experience in 500cases from a single institution显示文摘 | Gerszten P C Burton S A Ozhasoglu C | 2007 | Spine (Phi la Pal976)2007，32，2： | 1 |
| 14 | A cluster randomised controlled trial of an occupational therapy intervention for residents with stroke living in UK care homes(OTCH):study protocol显示文摘 | Sackley CM Burton CR Herron-Marx S | 2012 | BMC Neurol2012，9，： | 1 |
| 15 | A literature review of low pressure steam turbine exhaust hood and diffuser studies显示文摘 | BURTON Z INGRAM G L HOGG S | 2013 | ASME Journal of Engineering for Gas Turbines and Power2013，1356，06： | 1 |
| 16 | A systematic review of psychologic factors as predictors of chronicity/disability in prospective cohorts of low back pain显示文摘 | Pincus T Burton A K Vogel S | 2002 | Spine2002，27，5： | 1 |
| 17 | Starch granule initiation and growth are altered in barly mutant that lack isoamylase activity显示文摘 | Jenner H Carrangis L Fahy B Fincher G B Hylton C Laurie D A Parker M Waite D Wagen S V Verhoeven T Denyer K | 2002 | The Plant Journal2002，31，1： | 1 |
| 18 | Fine root architecture of nine North American trees 显示文摘 | PREGITZER K S DEFOREST J L BURTON A J | 2002 | Ecological Monographs2002，72，： | 1 |
| 19 | Finite element simulation of a serf-healing shape memory alloy composite显示文摘 | Burton D S Gao X Brinson L C | 2007 | Mechanics of Materials2007，38，55： | 1 |
| 20 | Fine root architecture of nine North American trees显示文摘 | Pregitzer K S Deforest J L Burton A J | 2002 | Ecological Monographs2002，72，2： | 1 |
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