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| 1 | Construction and external validation of a nomogram that predicts lymph node metastasis in early gastric cancer patients using preoperative parameters显示文摘Objective: To create a nomogram to predict the incidence of lymph node metastasis(LNM) in early gastric cancer(EGC) patients and to externally validate the nomogram.Methods: To construct the nomogram,we retrospectively analyzed a primary cohort of 272 EGC patients.Univariate analysis and a binary logistic regression were performed.A nomogram predicting the incidence of LNM in EGC patients was created.The discrimination ability of the nomogram was measured using the concordance index(c-index),and the nomogram was also calibrated.Then,another prospective cohort of 81 patients was analyzed to validate the nomogram.Results: In the primary cohort,LNM was pathologically confirmed in 37(13.6%) patients.In multivariate analysis,the presence of an ulcer,the maximum lesion diameter observed via gastroscopy,the thickness of the lesion observed via endoscopic ultrasonography,and the presence of enlarged lymph nodes on computed tomography(CT) were independent risk factors for LNM.A nomogram was then created based on the regression model with the c-index of 0.905,and the calibration curve of the nomogram fell approximately on the ideal 45-degree line.The cut-off score of the nomogram was 110,and the sensitivity,specificity,positive predictive and negative predictive values of the nomogram in the primary cohort were 81.1%,86.0%,47.6% and 96.7%,respectively,and in the prospective validation cohort were 75.0%,91.0%,60.0% and 95.5%,respectively.The calibration curve of the external validation cohort was almost on the 45-degree line.Conclusions: We developed an effective nomogram predicting the incidence of LNM for EGC patients. | Yinan Zhang Yiqiang Liu Ji Zhang Xiaojiang Wu Xin Ji Tao Fu Ziyu Li Qi Wu Zhaode Bu Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，6： | 12 |
| 2 | Compressed sensing SAR imaging based on sparse representation in fractional Fourier domain显示文摘Compressed sensing(CS)is a new technique of utilizing a priori knowledge on sparsity of data in a certain domain for minimizing necessary number of measurements.Based on this idea,this paper proposes a novel synthetic aperture radar(SAR)imaging approach by exploiting sparseness of echo data in the fractional Fourier domain.The effectiveness and robustness of the approach are assessed by some numerical experiments under various noisy conditions and different measurement matrices.Experimental results have shown that,the obtained images by using the CS technique depend on measurement matrix and have higher output signal to noise ratio than traditional pulse compression technique.Finally simulated and real data are also processed and the achieved results show that the proposed approach is capable of reconstructing the image of targets and effectively suppressing noise. | BU HongXia BAI Xia TAO Ran | 2012 | Science China(Information Sciences)2012，55，8： | 12 |
| 3 | Characteristics of the HIV/AIDS Epidemic in Women Aged 15-49 Years from 2005 to 2012 in China显示文摘Objective To describe the characteristics of the HIV/AIDS epidemic in women aged 15-49 years in China. Methods HIV/AIDS cases from 2005 to 2012 that fulfilled the inclusion and exclusion criteria were identified on the Chinese HIV/AIDS case reporting system. Descriptive and spatial analyses were performed. Results A total of 103,559 female HIV/AIDS cases were included in our study. Based on the descriptive analysis, between 2005 and 2012, the proportion of heterosexually acquired HIV infection among women(15-49 years) increased rapidly from 35.8% to 87.4%. Approximately 60% of these cases were infected through non-marital heterosexual contact. Among older women(40-49 years), a slightly increasing trend was identified. The spatial analysis detected ‘hot spots' in the Xinjiang, Yunnan, Sichuan, Guangxi, and Chongqing provinces. The epidemic trends in these areas were predominately driven by heterosexual transmission. Conclusion Non-marital heterosexual contact is a very important factor in the HIV/AIDS epidemic in women aged 15-49 years, and the HIV infection rate in older women is increasing. Several epidemic hot spots were detected in northwestern and southwestern China. Efficient interventions are needed to control the spread of HIV/AIDS among women living in these areas. | ZHANG Xia Yan HUANG Tao FENG Yi Bing LI Meng CHEN Fang Fang LI Yin Ge JIN Shan Shan BU Kai WANG Lu | 2015 | Biomedical and Environmental Sciences2015，28，10： | 10 |
| 4 | Efficacy and Safety of Teriflunomide in Chinese Patients with Relapsing Forms of Multiple Sclerosis: A Subgroup Analysis of the Phase 3 TOWER Study显示文摘Background:Disease-modifying therapy is the standard treatment for patients with multiple sclerosis (MS)in remission.The primary objective of the current analysis was to assess the efficacy and safety of two teriflunomide doses (7mg and 14mg)in the subgroup of Chinese patients with relapsing MS included in the TOWER study. Methods:TOWER was a multicenter,multinational,randomized, double-blind,parallel-group (three groups),placebo-controlled study.This subgroup analysis includes 148 Chinese patients randomized to receive either teriflunomide 7mg (n =51), teriflunomide 14mg (n=43),or placebo (n=54). Results:Of the 148patients in the intent-to-treat population, adjusted annualized-relapse rates were 0.63(95% confidence interval [CI]:0.44,0.92)in the placebo group,0.48(95%CI:0.33, 0.70)in the teriflunomide 7mg group,and 0.18(95%CI:0.09,0.36)in the terifltmomide 14mg group;this corresponded to a significant relative risk reduction in the teriflunomide 14mg group versus placebo (-71.2%,P =0.0012).Terifiunomide 14mg also tended to reduce 12-week confirmed disability worsening by 68.1% compared with placebo (hazard ratio:0.319,P =0.1194).There were no differences across all treatment groups in the proportion of patients with treatment-emergent adverse events (TEAEs;72.2% in the placebo group,74.5%in the teriflunomide 7mg group,and 69.8% in the teriflunomide 14mg group);corresponding proportions for serious adverse events were 11.1%,3.9%,and 11.6%,respectively.The most frequently reported TEAEs with teriflunomide versus placebo were neutropenia,increased alanine aminotransferase,and hair thinning. Conclusions:Teriflunomide was as effective and safe in the Chinese subpopulation as it was in the overall population of patients in the TOWER trial.Teriflunomide has the potential to meet unmet medical needs for MS patients in China. | Wei Qiu De-Hui Huang Shi-Fang Hou Mei-Ni Zhang Tao Jin Hui-Qing Dong Hua Peng Chao-Dong Zhang Gang Zhao Yi-Ning Huang Dong Zhou Wei-Ping Wu Bao-Jun Wang Ji-Mei Li Xing-Hu Zhang Yan Cheng Hai-Feng Li Ling Li Chuan-Zhen Lu Xu Zhang Bi-Tao Bu Wan-Li Dong Dong-Sheng Fan Xue-Qiang Hu Xian-Hao Xu | 2018 | Chinese Medical Journal2018，，23： | 10 |
| 5 | Crop rotation-dependent yield responses to fertilization in winter oilseed rape(Brassica napus L.)显示文摘Differences in soil physical, chemical and biological properties between paddy–upland and continuous upland rotations will influence nutrient relations and crop growth. With the aim of estimating rapeseed yield performance in response to fertilization in rice–rapeseed(RR) and cotton–rapeseed(CR) rotations, on-farm experiments were conducted at 70 sites across Hubei province, central China. The economically optimal fertilizer rates of winter oilseed rape in different rotations were determined. Field experiments showed that previous crops significantly influenced seed yields. Without N fertilization,seed yields were significantly lower for the RR rotation than for the CR rotation. The average yield increase ratio and agronomic efficiency associated with nitrogen(N)fertilization in the RR rotation were 96.6% and 6.56 kg kg- 1, significantly higher than those in the CR rotation. No seed yield differences were detected between the two rotations under phosphorus(P) and potassium(K) fertilization. In contrast to the CR rotation, N fertilizer played a more vital role in maintaining high seed yields in the RR rotation owing to the lower indigenous soil N supply. Compared with local N fertilizer recommendation rates for the RR rotation, on average an additional 18 kg N ha- 1was recommended according to the economically optimal N fertilizer rate(EONFR). In contrast, the EONFR was 14 kg N ha- 1lower than the locally recommended N fertilizer rate for the CR rotation. There were no differences between the two rotations for the average economically optimal P and K fertilization rates. Consequently, the average EONFR of winter oilseed rape could be reduced if cotton rather than rice preceded the winter oilseed rape. | Tao Ren Hui Li Jianwei Lu Rongyan Bu Xiaokun Li Rihuan Cong Mingxing Lu | 2015 | The Crop Journal2015，3，5： | 8 |
| 6 | Isolation and identification of Serratia marcescens Ha1 and herbicidal activity of Ha1 ‘pesta’ granular formulation显示文摘A total of 479 bacterial strains were isolated from brine(Bohai, Qinhuangdao City, Hebei Province, China). Bioassay results indicated that 4 strains named Ha1, Ha17, Ha38, and Ha384 had herbicidal activity. And strain Ha1 had the highest effective herbicidal activity. As a result, this study aims to identify strain Ha1, characterize its physiological and biological activities, evaluate the herbicidal activity of its metabolites, and develop a ‘pesta' formulation and assess its effectiveness on Digitaria sanguinalis. Ha1 was identified as Serratia marcescens based on 16 S r DNA sequencing. This strain has a flagellum, a diameter of 0.5 to 0.8 μm, and a length of 0.9 to 2.0 μm. The indole test shows positive results, and the catalase enzyme exhibits strong positive reactions. Results further showed that the inhibitory concentration(IC50) of the crude extracts to D. sanguinalis radicula and coleoptile were 3.332 and 2.828 mg m L–1, respectively. Both the suppression of D. sanguinalis and the cell viability of the Ha1 formulation in ‘pesta' were higher when stored at 4°C than at(25±2)°C. These results indicated that S. marcescens Ha1 can potentially be used as a biocontrol agent against D. sanguinalis. | YANG Juan WANG Wei YANG Peng TAO Bu YANG Zheng ZHANG Li-hui DONG Jin-gao | 2015 | Journal of Integrative Agriculture2015，14，7： | 8 |
| 7 | Polycyclic aromatic hydrocarbon concentrations, compositions, sources, and associated carcinogenic risks to humans in farmland soils and riverine sediments from Guiyu, China显示文摘The concentrations of 16 priority polycyclic aromatic hydrocarbons(PAHs) were measured in 23 farmland soil samples and 10 riverine sediment samples from Guiyu, China, and the carcinogenic risks associated with PAHs in the samples were evaluated. Guiyu is the largest electronic waste(EW) dismantling area globally, and has been well known for the primitive and crude manner in which EWs are disposed, such as by open burning and roasting. The total PAH concentrations were 56–567 ng/g in the soils and 181–3034 ng/g in the sediments.The Shanglian and Huamei districts were found to be more contaminated with PAHs than the north of Guiyu. The soils were relatively weakly contaminated but the sediments were more contaminated, and sediments in some river sections might cause carcinogenic risks to the groundwater system. The PAHs in the soils were derived from combustion sources,but the PAHs in the sediments were derived from both combustion and petroleum sources. | Pengjun Xu Bu Tao Zhiqiang Ye Hu Zhao Yue Ren Ting Zhang Yeru Huang Jiping Chen | 2016 | Journal of Environmental Sciences2016，28，10： | 8 |
| 8 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 9 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 10 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 11 | Discovering Overlapping Communities by Clustering Local Link Structures显示文摘Recent advances point out that the existing community detection methods commonly face two challenges:incorrect base-structures and incorrect membership of weak-ties.To overcome both problems,a Local link structure(LLS) clustering based method for overlapping community detection is proposed.We extend the similarity of a pair of links to a group of links named LLS,and thus transform mining LLSs as a pattern mining problem.We prove that LLS with an appropriate threshold can filter weak-ties in the form of bridge and local bridge with its span being larger than 3.A compositive framework is presented for overlapping community detection based on LLS mining and clustering.Comparative experiments on both synthetical and real-world networks demonstrate that our method has advantage over six existing methods on discovering higher quality communities. | TAO Haicheng WANG Youquan WU Zhi'ang BU Zhan CAO Jie | 2017 | Chinese Journal of Electronics2017，26，2： | 3 |
| 12 | Diagnostic value of negative enrichment and immune fluorescence in situ hybridization for intraperitoneal free cancer cells of gastric cancer显示文摘Objective:To explore the intraperitoneal free cancer cell(IFCC)detection value of negative enrichment and immune fluorescence in situ hybridization(NEimFISH)on chromosomes(CEN)8/17.Methods:To verify the reliability of NEimFISH,29 gastric cancer tumors,their adjacent tissues and greater omental tissues were tested.Our study then included 105 gastric cancer patients for IFCC.We defined patients as IFCC-positive if a signal was detected,regardless of the detailed cancer cell numbers.A comparison of clinicopathological features was conducted among IFCC groups.We also compared the diagnosis value and peritoneal recurrence predictive value among different detection methods.The comparison of IFCC number was also conducted among different groups.Results:A cutoff of 2.5 positive cells could distinguish all benign tissue samples and 97%of malignant tissue samples in our study.Compared to intestinal gastric cancer,patients with diffuse gastric cancer tended to have more IFCCs(6 vs.4,P=0.002).The IFCC counts were often higher in the lymphovascular invasion positive group than negative group(3 vs.1,P=0.022).All IFCC samples that were considered positive using conventional cytology were also found to be positive using NEimFISH.When compared to conventional cytology and paraffin pathology,NEimFISH had a higher IFCC positive rate(68.9%)and higher one-year peritoneal recurrence predictive value with area under the curve(AUC)of 0.922.Conclusions:Gastric cancer could be effectively diagnosed by NEimFISH.The IFCC number found using NEimFISH on CEN8/17 is closely associated with Lauren type and vascular invasion of cancer.NEimFISH is a reliable detection modality with a higher positive detection rate,higher one-year peritoneal recurrence predictive value and quantitative features for IFCC of gastric cancer. | Anqiang Wang Zhongwu Li Qian Wang Yali Bai Xin Ji Tao Fu Ke Ji Yanwen Xue Tingxu Han Xiaojiang Wu Ji Zhang Yingjie Yang Guobin Xu Zhaode Bu Jiafu Ji | 2019 | Chinese Journal of Cancer Research2019，31，6： | 3 |
| 13 | Predictive Adaptive Kalman Filter and Its Application to INS/UWB-integrated Human Localization with Missing UWB-based Measurements显示文摘In order to improve the accuracy of the data fusion filter, a tightly-coupled ultra wide band(UWB)/inertial navigation system(INS)-integrated scheme for indoor human navigation will be investigated in this paper. In this scheme, the data fusion filter employs the difference between the INS-measured and UWB-measured distances as the observation. Moreover, the predictive adaptive Kalman filter(PAKF) for the tightly-coupled INS/UWB-integrated human tracking model with missing data of the UWB-measured distance will be designed, which considers the missing data of the UWB-based distance and employs the predictive UWB-measured distance. Real test results will be done to compare the performance of the Kalman filter(KF), adaptive Kalman filter(AKF), and the PAKF. The test results show that the performance of the AKF is better than the KF. Moreover, the proposed PAKF is able to maintain the performance of the filter when the UWB-based measurement is unavailable. | Yuan Xu Tao Shen Xi-Yuan Chen Li-Li Bu Ning Feng | 2019 | International Journal of Automation and computing2019，16，5： | 2 |
| 14 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 15 | PKC inhibition of sotrastaurin hasantitumor activity in diffuse large B-cell lymphoma via regulating the expression of MCT-1显示文摘MCT-1 (在 T 房间 lymphoma-1 的多重拷贝) ,新奇 oncogene,原来在 T 房间淋巴瘤被识别。最近的研究证明了 MCT-1 高度在 85% 弥漫的大 B 房间淋巴瘤(DLBCL ) 被表示。PKC (蛋白质 kinase C ) 为激活细胞的功能和增长为多重生物学上活跃的物质在信号 transduction 起一个必要作用。在这研究,我们发现 MCT-1 的 mRNA 和蛋白质表示层次显然在在 SUDHL-4 和 OCI-LY8 DLBCL 房间线由 siRNA 将 PKC 击倒以后被减少。在一个剂量依赖者和时间依赖者举止的一个选择 PKC 禁止者, sotrastaurin,有效地禁止的房间增长和导致的房间 apoptosis。同时,我们也观察到房间周期在对待 sotrastaurin 的房间在 G1 阶段被逮捕。另外, MCT-1 在在 vivo 的 sotrastaurin 处理组是下面调整的。而且,我们证明 PKC 禁止者 sotrastaurin 通过调整 MCT-1 的表示潜在地在 DLBCL 房间导致了房间 apoptosis 和房间周期拘捕。我们的数据建议那指向的 PKC 可以是为展出 MCT-1 的高水平的淋巴瘤和相关恶意的一条潜在的治疗学的途径蛋白质。 | Gaomei Chang Jiayi Zheng Wenqin Xiao Shuaikang Chang Qing Wei Huiqun Wu Yi Tao Guang Yang Bingqian Xie Xiucai Lan Yingcong Wang Dandan Yu Liangning Hu Yongsheng Xie Wenxuan Bu Yuanyuan Kong Bojie Dai Jun Hou Jumei Shi | 2018 | Acta Biochimica et Biophysica Sinica2018，50，4： | 2 |
| 16 | A facile and general method for synthesis of antibiotic-free protein-based hydrogel:Wound dressing for the eradication of drug-resistant bacteria and biofilms显示文摘Antibacterial protein hydrogels are receiving increasing attention in the aspect of bacteria-infected-wound healing. However, bacterial drug resistance and biofilm infections lead to hard healing of wounds, thus the construction of biological agents that can overcome these issues is essential. Here, a simple and universal method to construct antibiotic-free protein hydrogel with excellent biocompatibility and superior antibacterial activity against drug-resistant bacteria and biofilms was developed. The green industrial microbicide tetrakis (hydroxymethyl) phosphonium sulfate (THPS) as cross-linking agent can be quickly cross-linked with model protein bovine serum albumin (BSA) to form antibacterial hydrogel through simple mixing without any other initiators, subsequently promoting drug-resistance bacteria-infected wound healing. This simple gelatinization strategy allows at least ten different proteins to form hydrogels (e.g. BSA, human serum albumin (HSA), egg albumin, chymotrypsin, trypsin, lysozyme, transferrin, myohemoglobin, hemoglobin, and phycocyanin) under the same conditions, showing prominent universality. Furthermore, drug-resistance bacteria and biofilm could be efficiently destroyed by the representative BSA hydrogel (B-Hydrogel) with antibacterial activity, overcoming biofilm-induced bacterial resistance. The in vivo study demonstrated that the B-Hydrogel as wound dressing can promote reepithelization to accelerate the healing of methicillin-resistant staphylococcus aureus (MRSA)-infected skin wounds without inducing significant side-effect. This readily accessible antibiotic-free protein-based hydrogel not only opens an avenue to provide a facile, feasible and general gelation strategy, but also exhibits promising application in hospital and community MRSA disinfection and treatment. | Jiang Ouyang Qingyue Bu Na Tao Mingkai Chen Haijun Liu Jun Zhou Jinggong Liu Bo Deng Na Kong Xingcai Zhang Tianfeng Chen Yihai Cao Wei Tao | 2022 | Bioactive Materials2022，7，12： | 2 |
| 17 | A systematic review of matrix metalloproteinase 9 as a biomarker of survival in patients with osteosarcoma显示文摘 | Hui Li Kun Zhang Li-hong Liu Yurong Ouyang Jie Bu Hong-bin Guo Tao Xiao | 2014 | Tumor Biology2014，，6： | 2 |
| 18 | Developing a duplex ARMS-qPCR method to differentiate genotype Ⅰ and Ⅱ African swine fever viruses based on their B646L genes显示文摘Africanswinefever(ASF),causedbythe African swine fever virus (ASFV), is an acute, hemorrhagic, and contagious disease of domestic pigs and wild boars.The disease is notifiable and listed by the World Organization for Animal Health (WOAH)(Wang N et al. 2019). | DING Lei-lei REN Tao HUANG Lian-yu Weldu TESFAGABER ZHU Yuan-mao LI Fang SUN En-cheng BU Zhi-gao ZHAO Dong-ming | 2023 | Journal of Integrative Agriculture2023，22，5： | 2 |
| 19 | The role of statins in erectile dysfunction: a systematic review and meta-analysis显示文摘为可勃起的机能障碍(编辑) 评估 statins 的效果,文学的系统的评论从每个数据库的开始在 Cochrane 图书馆, Embase 和 PubMed 被进行到 2013 年 6 月。为编辑把处理与 statins 作比较的仅仅使随机化的控制试用(RCT ) 被识别。有可勃起的功能(IIEF ) 的国际索引的安慰剂 RCT 为元分析作为结果措施是合格的。包括有 586 个病人的一个总数的二 statins 的七 RCT 的一个总数严格地为系统的评论满足了我们的标准,他们中的五个为元分析取得资格。用一个随机的效果模型的元分析证明 statins 与 IIEF-5 分数的重要增加被联系(吝啬的差别(MD ) :3.27;95% 机密间隔(CI ): 1.51 ~ 5.02;P <0.01 ) 并且类脂化合物的全面改进介绍包括全部的胆固醇(MD:− 1.08;95% CI:− 1.68 到 − 0.48;P <0.01 ) ,低密度的脂蛋白(LDL ) 胆固醇(MD:− 1.43;95% CI:− 2.07 到 − 0.79;P <0.01 ) ,高密度的脂蛋白(HDL ) 胆固醇(MD:0.24;95% CI:0.13 ~ 0.35;P <0.01 ) 并且 triglycerides (TG )(MD:− 0.55;95% CI:− 0.61 到 − 0.48;P <0.01 ) 。在摘要,我们的学习在可勃起的功能上揭示了这些类脂化合物阴沉的药的积极后果,特别为到 phosphodiesterase 类型 5 禁止者(PDE5Is ) 的 nonresponders。然而, statin 治疗可以减少睾丸激素的层次并且因此加重编辑的症状,这被报导了,更大的、设计得好的 RCT 被需要在编辑的处理调查 statins 的双重的角色。 | Xiang Cai Ye Tian Tao Wu Chen-Xi Cao Si-Yuan Bu Kun-Jie Wang | 2014 | Asian Journal of Andrology2014，16，3： | 2 |
| 20 | Dual effects of nitric oxide on meiotic maturation of mouse cumulus cell- enclosed ooeytes in vitro 显示文摘 | BU S XIA G TAO Y | 2003 | Mol Cell Endocrinol2003，207，： | 1 |
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