|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump显示文摘AIM: To study the association of three common ABCB11 and ABCC2 polymorphisms (ABCB11: 1331T>C V444A; ABCC2: 3563T>A V1188E and 4544G>A C1515Y) with intrahepatic cholestasis of pregnancy (ICP) and contraceptive-induced cholestasis (CIC). METHODS: ABCB11 and ABCC2 genotyping data were available from four CIC patients and from 42 and 33 ICP patients, respectively. Allele-frequencies of the studied polymorphisms were compared with those in healthy pregnant controls and Caucasian individuals. Furthermore, serum bile acid levels were correlated with the presence or absence of the 1331 C allele.RESULTS: The ABCB11 1331T>C polymorphism was significantly more frequent in cholestatic patients than in pregnant controls: C allele 76.2% (CI, 58.0-94.4) vs 51.3% (CI 35.8-66.7), respectively (P = 0.0007); and CC allele 57.1% (CI 36.0-78.3) vs 20% (CI 7.6-32.4), respectively (P = 0.0065). All four CIC patients were homozygous carriers of the C allele. In contrast, none of the studied ABCC2 polymorphism was overrepresented in ICP or CIC patients. Higher serum bile acid levels were found in carriers of the 1331CC genotype compared to carriers of the TT genotype.CONCLUSION: Our data support a role for the ABCB11 1331T>C polymorphism as a susceptibility factor for the ←←← development of estrogen-induced cholestasis, whereas no such association was found for ABCC2. Serum bile acid and γ-glutamyl transferase levels might help to distinguish ABCB4- and ABCB11-related forms of ICP and CIC. | Yvonne Meier Tina Zodan Carmen Lang Roland Zimmermann Gerd A Kullak-Ublick Peter J Meier Bruno Stieger Christiane Pauli-Magnus | 2008 | World Journal of Gastroenterology2008，14，1： | 20 |
| 2 | Physiological and Biochemical Basis of Clinical Liver Function Tests: A Review显示文摘 | Lisette T. Hoekstra Wilmar de Graaf Geert A. A. Nibourg Michal Heger Roelof J. Bennink Bruno Stieger Thomas M. van Gulik | 2013 | Annals of Surgery2013，，1： | 3 |
| 3 | Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver显示文摘Dear Editor,The sodium taurocholate(TC)co-transporting polypeptide NTCP(SLC10A1)is a secondary active membrane transport protein that mediates the uptake of bile salts from the portal blood plasma into the cytoplasm of liver cells.NTCP was originally cloned from rat and demonstrated to be localized in the basolateral membrane.1 Its activity is a key component of bile acid homeostasis and enterohepatic circulation of bile salts(Fig.1a),a process that includes at least three additional transporter proteins,namely BSEP,ASBT and OSTα/β.2,3 In addition to its role in mediating bile salt uptake,NTCP also serves as the receptor of the human hepatitis B and D viruses.4 The mechanism by which NTCP recognizes and transports bile salts is not understood,in part because no structural insight into the interaction of NTCP with its substrates is available.While recent studies reported structures of NTCP bound to inhibitory nanobodies5 or Fab fragments,6,7 no substrate-binding pockets were identified. | Hongtao Liu Rossitza N.Irobalieva Rose Bang-Sørensen Kamil Nosol Somnath Mukherjee Parth Agrawal Bruno Stieger Anthony A.Kossiakoff Kaspar P.Locher | 2022 | Cell Research2022，32，8： | 2 |
| 4 | Stable expression and functional characterization of a Na+-taurocholate cotransporting green fluorescent protein in human hepatoblastoma HepG2 cells显示文摘 | Gerd A. Kullak-Ublick Manfred G. Ismair Ralf Kubitz Marcus Schmitt Dieter H?ussinger Bruno Stieger Bruno Hagenbuch Peter J. Meier Ulrich Beuers Gustav Paumgartner | 2000 | Cytotechnology (-)2000，，1： | 1 |
| 5 | Chronic cholestatic liver diseases: Clues from histopathology for pathogenesis显示文摘 | Marion J. Pollheimer Peter Fickert Bruno Stieger | 2014 | Molecular Aspects of Medicine2014，，： | 1 |
| 6 | Hepatic Transport of Bile Salts显示文摘 | GERD KULLAK-UBLICK BRUNO STIEGER BRUNO HAGENBUCH PETER MEIER | 2000 | Semin Liver Dis2000，，03： | 1 |
| 7 | Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver显示文摘 | Gerd A. Kullak-Ublick Bruno Hagenbuch Bruno Stieger Claudio D. Schteingart Alan F. Hofmann Allan W. Wolkoff Peter J. Meier | 1995 | Gastroenterology1995，，4： | 1 |
| 8 | Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury显示文摘 | Carmen Lang Yvonne Meier Bruno Stieger Ulrich Beuers Thomas Lang Reinhold Kerb Gerd A. Kullak-Ublick Peter J. Meier Christiane Pauli-Magnus | 2007 | Pharmacogenetics and Genomics2007，，1： | 1 |
| 9 | The bile salt export pump显示文摘 | Bruno Stieger Yvonne Meier Peter J. Meier | 2007 | Pflügers Archiv - European Journal of Physiology2007，，5： | 1 |
| 10 | 239 Interindividual variability of canalicular ATP-binding-casette (ABC)-transporter expression in human liver显示文摘 | Yvonne Meier Bruno Stieger Karin Fattinger Ulrich Zanger Peter J. Meier Christine Pauli-Magnus Yvonne Meier | 2003 | Hepatology2003，，： | 1 |
| 11 | Distribution and functional activity of P-glycoprotein and multidrug resistance-associated proteins in human brain microvascular endothelial cells in hippocampal sclerosis显示文摘 | Hisashi Kubota Hideyuki Ishihara Thomas Langmann Gerd Schmitz Bruno Stieger Heinz-Gregor Wieser Yasuhiro Yonekawa Karl Frei | 2005 | Epilepsy Research2005，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员