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| 1 | Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor显示文摘AIM: To assess the rate of infection, appropriateness of antimicrobial-therapy and mortality on intensive care unit(ICU). Special focus was drawn on patients with liver cirrhosis.METHODS: The study was approved by the local ethical committee. All patients admitted to the Internal Medicine-ICU between April 1, 2007 and December 31, 2009 were included. Data were extracted retrospectively from all patients using patient charts and electronic documentations on infection, microbiological laboratory reports, diagnosis and therapy. Due to the large hepatology department and liver transplantation center, special interest was on the subgroup of patients with liver cirrhosis. The primary statistical-endpoint was the evaluation of the influence of appropriate versusinappropriate antimicrobial-therapy on in-hospitalmortality.RESULTS: Charts of 1979 patients were available. The overall infection-rate was 53%. Multiresistantbacteria were present in 23% of patients with infection and were associated with increased mortality(p < 0.000001). patients with infection had significantly increased in-hospital-mortality(34% vs 17%, p < 0.000001). Only 9% of patients with infection received inappropriate initial antimicrobial-therapy, no influence on mortality was observed. Independent risk-factors for in-hospital-mortality were the presence of septicshock, prior chemotherapy for malignoma and infection with pseudomonas spp. Infection and mortality-rate among 175 patients with liver-cirrhosis was significantly higher than in patients without liver-cirrhosis. Infection increased mortality 2.24-fold in patients with cirrhosis. patients with liver cirrhosis were at an increased risk to receive inappropriate initial antimicrobial therapy.CONCLUSION: The results of the present study report the successful implementation of early-goal-directed therapy. Liver cirrhosis patients are at increased risk of infection, mortality and to receive inappropriate therapy. Increasing burden are multiresistant-bacteria. | Mireen Friedrich-Rust Beate Wanger Florian Heupel Natalie Filmann Reinhard Brodt Volkhard AJ Kempf Johanna Kessel Thomas A Wichelhaus Eva Herrmann Stefan Zeuzem Joerg Bojunga | 2016 | World Journal of Gastroenterology2016，22，16： | 6 |
| 2 | Inhibition of the type 1 insulin - like growth factor receptor expression and signaling:novel strategies for antimetastatic therapy 显示文摘 | BRODT P SAMANI A NAVAB R | 2000 | Biochem Pharmacol2000，60，： | 1 |
| 3 | Managers asinitiators of trust: An exchange relationship frame work forunderstanding managerial trustworthy behavior 显示文摘 | Whitener E M Brodt S E Korsgaard M A | 1998 | Academy ofManagement Review1998，23，3： | 1 |
| 4 | Identification of a novel coronavirus in patients with severe acute respiratory syndrome显示文摘 | Gunther S Preiser W van der Weft S Brodt HR Becker S Rabenau H Panning M Kolesnikova L Fouchier RA Berger A Burguiere AM Cinatl J Eickmann M Escriou N Grywna K Kramme S Manuguerra JC Muller S Rickerts V Sturmer M Vieth S Klenk HD Osterhaus AD Schmitz H Doerr HW | 2003 | N Engl J Med2003，348，： | 1 |
| 5 | Inhibition of the type Ⅰ insulin-like growth factor receptor expression and signaling:novel strategies for antimetastatic therapy显示文摘 | Brodt P Samani A Navab R | 2000 | Biochem Pharmacol2000，60，8： | 1 |
| 6 | CRISPR/Cas systems in archaea 显示文摘 | Gophna U Brodt A | 2012 | Mobile Genetic Elements2012，2，1： | 1 |
| 7 | Managers as Initiators of Trust:An Exchange Relationship Framework for Understanding Managerial Trustworthy Behavior 显示文摘 | Whitener E M Brodt S E Korsgaard M A J M Werner | 1998 | Academy of Management Review1998，23，3： | 1 |
| 8 | Trust in the face of conflict : the role of managerial trustworthy behavior and organizational context 显示文摘 | Korsgaard M A Brodt S E Whitener E M | 2002 | Journal of Applied Psychology2002，87，2： | 1 |
| 9 | Managers as Initi- ators of Trust : An Exchange Relationship Framework for Understand- ing Managerial Trustworthy Behavior 显示文摘 | Whitener E M Brodt S E Korsgaard M A | 1998 | Academy of Management Review1998，23，3： | 1 |
| 10 | Managers as Initiators of Trust: An Exchange Relationship Framework for Understanding Managerial Trustworthy Behavior显示文摘 | WHITENER E M BRODT S E KORSGAARD M A | 1998 | Academy of Management Review1998，23，3： | 1 |
| 11 | Managers as Initiators of Trust:An Exchange Relationship for Understanding Managerial Trustworthy Behavior显示文摘 | Brodt S Korsgaard M A Werner J | 1998 | Academy of Management Journal1998，，5： | 1 |
| 12 | Inhibition of the type I insulin-like growth factor receptor expression and signaling: novel strategies for antimetastatic therapy 显示文摘 | Brodt P Samani A Navab R | 2000 | Biochem Pharmacol2000，60，8： | 1 |
| 13 | Inhibition of the type I insulin-like growth factor receptor expression and signaling:novel strategies for antimetastatic therapy显示文摘 | BRODT P SAMANI A NAVAB R | | 0，，： | 1 |
| 14 | The receptor for the type I insulin-like growth factor and its ligands regulate multiple cellular functions that impact on metastasis 显示文摘 | Samani A A Brodt P | 2001 | Surg Oncol Clin N Am2001，10，2： | 1 |
| 15 | Managers as initiators of trust: An exchange relationship framework for understanding managerial trustworthy behavior 显示文摘 | Whitener E M Brodt S E Korsgaard M A | 1998 | Academy of Management Review1998，23，3： | 1 |
| 16 | Managers as initiators of trust: An exchange relationship framework for understanding managerial trustworthy behavior显示文摘 | Whitener E M Brodt S E Korsgaard M A and Werner J M | 1998 | Academy of Management Review1998，23，3： | 1 |
| 17 | Managers as initiators of trust : an exchange relationship framework for understand- ing managerial trustworthy behavior 显示文摘 | Whitener E M Brodt S E Korsgaard M A Weruer J M | 1998 | Acade- my of Management Review1998，23，： | 1 |
| 18 | Managers as initiators of trust:an exchange relationship framework for understanding managerial trustworthy behavior显示文摘 | WHITENER E M BRODT S E KORSGAARD M A | 1998 | Academy of Management Review1998，23，3： | 1 |
| 19 | Managers as Initiators of Trust:An Exchange Relationship Framework for Understanding Managerial Trustworthy Behavior显示文摘 | Whitener E M Brodt S E Korsgaard M A | 1998 | Academy of Management Review1998，23，2： | 1 |
| 20 | Trust in the face of conflict: The role of managerial trustworthy behavior and organizational context显示文摘 | Korsgaard M A Brodt S E and Whitener E M | 2002 | Journal of Applied Psychology2002，87，2： | 1 |
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