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| 1 | Efficacy of neoadjuvant therapy and surgical rescue for locally advanced hepatoblastomas:10 year single-center experience and literature review显示文摘AIM:To report our experience with long-term outcomes after multimodal management therapy.METHODS:An observational retrospective study was performed containing seven patients with hepatoblastoma(Hbl)treated in our institution,a tertiary referral center,from 2003 to 2011.Demographic,preoperative,surgical,and outcome variables were collected.A survival analysis and a review of the current literature related to combination neoadjuvant chemotherapy and surgical resection on Hbl were performed.RESULTS:The median age at surgery was 14.4 mo,with a male to female ratio of 4:3.Pretext staging at diagnosis was as follows:stageⅠ,4 cases;stageⅡ,2 patients;and stageⅢ,1 case.Mean pretreatment tumor volume was 735 cm3.Five out of seven patients received neoadjuvant chemotherapy according to SIOPEL-3 or SIOPEL-6 protocols.Tumor volume and alphafetoprotein levels significantly dropped after neoadjuvant therapy.Surgical procedures performed included hemihepatectomies,segmentectomies and atypical resection.All patients received chemotherapy after surgery.Median postoperative hospital stay was 8 d.All patients were alive and disease-free after a median follow-up period of 23 mo.With regards to the literature review,seventeen articles were found that were related to our search.CONCLUSION:Our series shows how multimodal management of Hbl,exhaustive control and a meticulous surgical approach leads to almost 100%complete resection with optimal postoperative results. | Dolores Ayllon Teran Oscar Gómez Beltran Rubén Ciria Bru Elena Mateos González María José Pea Rosa Antonio Luque Molina Pedro López Cillero Javier Briceo Delgado | 2014 | World Journal of Gastroenterology2014，20，29： | 12 |
| 2 | Reduced Exposure to Calcineurin Inhibitors Early After Liver Transplantation Prevents Recurrence of Hepatocellular Carcinoma显示文摘 | Manuel Rodríguez-Perálvarez Emmanuel Tsochatzis María Carmen Naveas Giulia Pieri Carmen García-Caparrós James O’Beirne Antonio Poyato-González Gustavo Ferrín-Sánchez Jose Luis Montero-álvarez David Patch Douglas Thorburn Javier Brice?o Manuel De la Mata A | 2013 | Journal of Hepatology2013，，： | 5 |
| 3 | Conservative management of perforated duodenal diverticulum: A case report and review of the literature显示文摘Duodenal diverticula are a relatively common condition. They are asymptomatic, unless they become complicated, with perforation being the rarest but most severe complication. Surgical treatment is the most frequently performed approach. We report the case of a patient with a perforated duodenal diverticulum, which was diagnosed early and treated conservatively with antibiotics and percutaneous drainage of secondary retroperitoneal abscesses. We suggest this method could be an acceptable option for the management of similar cases, provided that the patient is in good general condition and without septic signs. | David Martínez-Cecilia Alvaro Arjona Sánchez Manuel Gómez álvarez Eva Torres Tordera Antonio Luque Molina Victor Valentí Azcárate Javier Briceo Delgado Francisco Javier Padillo Pedro López-Cillero Sebastián Rufián Pea | 2008 | World Journal of Gastroenterology2008，14，12： | 2 |
| 4 | 策略将在肝移植以后减少丙肝病毒复发显示文摘 Hepatitis C virus (HCV) is a major health problem that leads to chronic hepatitis, cirrhosis and hepatocellular carcinoma, being the most frequent indication for liver transplantation in several countries. Unfortunately, HCV re-infects the liver graft almost invariably following reperfusion, with an accelerated history of recurrence, leading to 10%-30% of patients progressing to cirrhosis within 5 years of transplantation. In this sense, some groups have even advocated for not retransplanting this patients, as lower patient and graftoutcomes have been reported. However, the management of HCV recurrence is being optimized and several strategies to reduce post-transplant recurrence could improve outcomes, decrease the rate of re-transplantation and optimize the use of available grafts. Three moments may be the focus of potential actions in order to decrease the impact of viral recurrence: the pretransplant moment, the transplant environment and the post-transplant management. In the pre-transplant setting, it is not well established if reducing the pre transplant viral load affects the risk for HCV progression after transplant. Obviously, antiviral treatment can render the patient HCV RNA negative post transplant but the long-term benefit has not yet been fully established to justify the cost and clinical risk. In the transplant moment, factors as donor age, cold ischemia time, graft steatosis and ischemia/reperfusion injury may lead to a higher and more aggressive viral recurrence. After the transplant, discussion about immunosuppression and the moment to start the treatment (prophylactic, pre-emptive or once-confirmed) together with new antiviral drugs are of interest. This review aims to help clinicians have a global overview of posttransplant HCV recurrence and strategies to reduce its impact on our patients. | Ruben Ciria María Pleguezuelo Shirin Elizabeth Khorsandi Diego Davila Abid Suddle Hector Vilca-Melendez Sebastian Rufian Manuel de la Mata Javier Briceo Pedro López Cillero Nigel Heaton | 2013 | World Journal of Hepatology2013，5，5： | 2 |
| 5 | CriSTAL- Clear-cut? Facilitating health librarians to use information research in practice 显示文摘 | Booth A Brice A | 2003 | Health Information & Libraries Journal2003，20，： | 1 |
| 6 | Lympography: an old technique retains its usefulness 显示文摘 | Guermazi A Brice P Hennequin C | 2003 | Radiographics2003，23，6： | 1 |
| 7 | Alpha-synuclein and Parkinson′ s disease显示文摘 | Lucking C B Brice A | 2000 | Cell Mol Life Sci2000，57，1314： | 1 |
| 8 | What genetics tells us about the causes and mechanisms of Parkinson' s disease显示文摘 | Corti O Lesage S Brice A | 2011 | Physiol Rev2011，91，4： | 1 |
| 9 | Over-expression of sphingosinekinase-1 enhances a progenitor phenotype in humanendothelial cells显示文摘 | Barrett Jeffrey M Parham Kate A Pippal Jyotsna B CockshellMichaelia P Moretti Paul A B Brice Sarah L Pitson StuartM Bonder Claudine S | 2011 | Microcirculation2011，187，： | 1 |
| 10 | Extranodal Hodgkindisease: spectrum of disease 显示文摘 | Guermazi A Brice P de Kerviler EE | 2001 | Radiographics2001，21，1： | 1 |
| 11 | Trends in polycyclic aromatic hydrocarbon concentrations in the Great Lakes atmosphere 显示文摘 | Sun P Blanchard P Brice K A | 2006 | Environ Sci Technol2006，40，20： | 1 |
| 12 | Wavelet analysis显示文摘 | Brice A Donoho D Gao H Y | 1996 | IEEE Spectrum1996，33，10： | 1 |
| 13 | Trends in polycyclic aromatic hydrocarbon concentrations in the Great Lakes atmosphere显示文摘 | SUN P BLANCHARD P BRICE K A | 2006 | Environmental Science&Technology2006，40，： | 1 |
| 14 | The effects of caffeine on simulated driving, subjective alertness and sustained attention 显示文摘 | Brice C Smith A | 2001 | Hum Psycho- pharmaco12001，16，7： | 1 |
| 15 | Mitochondrial dysfunctions in Parkinson's disease 显示文摘 | Gautier CA Corti O Brice A | 2014 | Rev Neurol2014，170，5： | 1 |
| 16 | Choice of languages in instruction: One language or two ! 显示文摘 | Brice A Roseberry C | 2001 | Teaching Exceptional Children2001，，4： | 1 |
| 17 | Modeling and system identification of residential air conditioning load显示文摘 | Pahwa A Brice C W Ⅲ | 1985 | IEEE Trans on Power Apparatus and Systems1985，104，6： | 1 |
| 18 | Genetics of Parkinson's disease and biochemical studies of implicated gene products显示文摘 | Lansbury PT Jr Brice A | 2002 | Curr Opin Genet Dev2002，12，3： | 1 |
| 19 | Elevated temperature characterization of etectron beam freeform fabricated Ti-6AI-4~ and dispersion strengthened Ti-SAI+I Er 显示文摘 | Bush R W Brice C A | 2012 | Material Science and Engineering A2012，554，： | 1 |
| 20 | CYP2D6 polymorphism and Parkinson's desease susceptibility显示文摘 | Sabbagh N Brice A Marez D | 1999 | Mov Disord1999，14，： | 1 |
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