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| 1 | Estimates of gene flow in Eichhornia paniculata ( Pontederiaceae ) : e f fects of range substructure显示文摘 | Brian C Husband Spencer C H Barrett | 1995 | Heredity1995，75，： | 1 |
| 2 | A Novel Mutation of LAMB2 in a Multigenerational Mennonite Family Reveals a New Phenotypic Variant of Pierson Syndrome显示文摘 | Brian G. Mohney Jose S. Pulido Noralane M. Lindor Marie C. Hogan Mark B. Consugar Justin Peters V. Shane Pankratz Samih H. Nasr Stephen J. Smith James Gloor Vickie Kubly Dorothy Spencer Rebecca Nielson Erik G. Puffenberger Kevin A. Strauss D. Holmes Morto | 2011 | Ophthalmology2011，，6： | 1 |
| 3 | A higb performance liquid chromatography method for determination of gas-phase hydrogen peroxide in ambient air using Fenton's chemistry 显示文摘 | Jun Liu Spencer M Steinberg Brian J Johnson | 2003 | Chemosphere2003，52，5： | 1 |
| 4 | Estimates of gene flow in Eichhornia paniculata (Pontederiaceae):effects of range substructure显示文摘 | Brian C Husband Spencer C H Barrett | 1995 | Heredity1995，75，： | 1 |
| 5 | Long-term neprilysin gene transfer is associated with reduced levels of intracellular A-beta and behavioral improvement in APP transgenic mice 显示文摘 | Brian Spencer Robert A Marr | 2008 | BMC Neuroscience2008，9，12： | 1 |
| 6 | Assessing the contribution of wetlands and subsided islands to dissolved organic matter and disinfection byproduct precursors in the Sacramento–San Joaquin River Delta: A geochemical approach显示文摘 | Tamara E.C. Kraus Brian A. Bergamaschi Peter J. Hernes Robert G.M. Spencer Ramunas Stepanauskas Carol Kendall Richard F. Losee Roger Fujii | 2008 | Organic Geochemistry2008，，9： | 1 |
| 7 | Calcium pyrophosphate dihydrate crystals in a 9-year-old with osteomyelitis of the knee:A case report显示文摘BACKGROUND Calcium pyrophosphate dihydrate deposition disease(CPPD),or pseudogout,is an inflammatory arthritis common among elderly patients,but rarely seen in patients under the age of 40.In the rare cases presented of young patients with CPPD,genetic predisposition or related metabolic conditions were almost always identified.CASE SUMMARY The authors report the case of a 9-year-old boy with no past medical history who presented with acute knee pain and swelling after a cat scratch injury 5 d prior.Synovial fluid analysis identified calcium pyrophosphate dihydrate crystals.Further MRI analysis identified osteomyelitis and a small soft tissue abscess.CONCLUSION This case presents the extremely rare diagnostic finding of calcium pyrophosphate dihydrate crystals in a previously healthy pediatric patient.The presence of osteomyelitis presents a unique insight into the pathogenesis of these crystals in pediatric patients.More research needs to be done on the role of CPPD in pediatric arthritis and joint infection. | William Pavlis David S Constantinescu Rajan Murgai Spencer Barnhill Brian Black | 2022 | World Journal of Orthopedics2022，13，9： | 1 |
| 8 | Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease显示文摘Background In Alzheimer’s Disease(AD),about one-third of the risk genes identified by GWAS encode proteins that function predominantly in the endocytic pathways.Among them,the Ras and Rab Interactor 3(RIN3)is a guanine nucleotide exchange factor(GEF)for the Rab5 small GTPase family and has been implicated to be a risk factor for both late onset AD(LOAD)and sporadic early onset AD(sEOAD).However,how RIN3 is linked to AD pathogenesis is currently undefined.Methods Quantitative PCR and immunoblotting were used to measure the RIN3 expression level in mouse brain tissues and cultured basal forebrain cholinergic neuron(BFCNs).Immunostaining was used to define subcellular localization of RIN3 and to visualize endosomal changes in cultured primary BFCNs and PC12 cells.Recombinant flag-tagged RIN3 protein was purified from HEK293T cells and was used to define RIN3-interactomes by mass spectrometry.RIN3-interacting partners were validated by co-immunoprecipitation,immunofluorescence and yeast two hybrid assays.Live imaging of primary neurons was used to examine axonal transport of amyloid precursor protein(APP)andβ-secretase 1(BACE1).Immunoblotting was used to detect protein expression,processing of APP and phosphorylated forms of Tau.Results We have shown that RIN3 mRNA level was significantly increased in the hippocampus and cortex of APP/PS1 mouse brain.Basal forebrain cholinergic neurons(BFCNs)cultured from E18 APP/PS1 mouse embryos also showed increased RIN3 expression accompanied by early endosome enlargement.In addition,via its proline rich domain,RIN3 recruited BIN1(bridging integrator 1)and CD2AP(CD2 associated protein),two other AD risk factors,to early endosomes.Interestingly,overexpression of RIN3 or CD2AP promoted APP cleavage to increase its carboxyl terminal fragments(CTFs)in PC12 cells.Upregulation of RIN3 or the neuronal isoform of BIN1 increased phosphorylated Tau level.Therefore,upregulation of RIN3 expression promoted accumulation of APP CTFs and increased phosphorylated Tau.These effects by RIN3 was rescued by the expression of a dominant negative Rab5(Rab5S34N)construct.Our study has thus pointed to that RIN3 acts through Rab5 to impact endosomal trafficking and signaling.Conclusion RIN3 is significantly upregulated and correlated with endosomal dysfunction in APP/PS1 mouse.Through interacting with BIN1 and CD2AP,increased RIN3 expression alters axonal trafficking and procession of APP.Together with our previous studies,our current work has thus provided important insights into the role of RIN3 in regulating endosomal signaling and trafficking. | Ruinan Shen Xiaobei Zhao Lu He Yongbo Ding Wei Xu Suzhen Lin Savannah Fang Wanlin Yang Kijung Sung Brian Spencer Robert A.Rissman Ming Lei Jianqing Ding Chengbiao Wu | 2020 | Translational Neurodegeneration2020，9，2： | 1 |
| 9 | A Statistical Model for Angle of Arrival in Indoor Multipath Propagation显示文摘 | QUENTIN SPENCER MICHAEL RICE BRIAN JEFFS | 1997 | IEEE Vehicular Technology Conference1997，3，： | 1 |
| 10 | Real-time hybrid simulation for structural control performance assessment显示文摘Real-time hybrid simulation is an attractive method to evaluate the response of structures under earthquake loads.The method is a variation of the pseudodynamic testing technique in which the experiment is executed in real time,thus allowing investigation of structural systems with rate-dependent components.Real-time hybrid simulation is challenging because it requires performance of all calculations,application of displacements,and acquisition of measured forces,within a very small increment of time.Furthermore,unless appropriate compensation for actuator dynamics is implemented,stability problems are likely to occur during the experiment.This paper presents an approach for real-time hybrid simulation in which compensation for actuator dynamics is implemented using a model-based feedforward compensator.The method is used to evaluate the response of a semi-active control of a structure employing an MR damper.Experimental results show good agreement with the predicted responses,demonstrating the effectiveness of the method for structural control performance assessment. | Juan E Carrion BF Spencer Jr Brian M Phillips | 2009 | Earthquake Engineering and Engineering Vibration2009，8，4： | 1 |
| 11 | Trifluoroacetic acid in ancient freshwater显示文摘 | Scott Brian F Spencer Christine | 2001 | Atmos Environ2001，35，： | 1 |
| 12 | Dorsal root ganglion progenitors differentiate to gamma-aminobutyric acid-and choline acetyltransferase-positive neurons显示文摘This study examined the isolation and differentiation of dorsal root ganglion progenitor cells for therapeutic use in neurodegenerative diseases. Rat embryonic dorsal root ganglia progenitors were isolated and purified using the differential adhesion method combined with cytosine arabinoside treatment. After culture in serum-free medium supplemented with B27, basic fibroblast growth factor and epidermal growth factor, these cells remained viable and survived for more than 18 months in vitro. Most cells differentiated to neurons that were immunoreactive for gamma-aminobutyric acid and choline acetyltransferase as detected by immunohistochemical staining. In addition, nerve growth factor and neurotrophic tyrosine kinase receptor expression were also observed in dorsal root ganglion progenitors and differentiated cells. K252a, an inhibitor that blocks nerve growth factor-induced signaling, inhibited cell survival, suggesting the possible existence of a nerve growth factor autocrine loop in these proliferating cells. | Lingli Yu Yindi Ding Ambre Spencer Ji Ma Ruisheng Lu Brian B.Rudkin Chonggang Yuan | 2012 | Neural Regeneration Research2012，7，7： | 1 |
| 13 | The prevalence of extracardiac findings by multidetector computed tomography before atrial fibrillation ablation显示文摘 | Brian J. Schietinger Ugur Bozlar Klaus D. Hagspiel Patrick T. Norton Heather R. Greenbaum Hongkun Wang David C. Isbell Rajan A.G. Patel John D. Ferguson Spencer B. Gay Christopher M. Kramer J. Michael Mangrum | 2008 | American Heart Journal2008，，： | 1 |
| 14 | The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid [beta] accumulation in mice显示文摘 | Pickford Fiona Masliah Eliezer Britschgi Markus Lucin Kurt Narasimhan Ramya Jaeger Philipp A Small Scott Spencer Brian Rockenstein Edward Levine Beth Wyss-Coray Tony | 2008 | Journal of Clinical Investigation2008，，6： | 1 |
| 15 | Cs_(3)Bi_(2)l_(9)-hydroxyapatite composite waste forms for cesium and iodine immobilization显示文摘Perovskite-based ceramic composites were developed as potential waste form materials for immobilizing cesium(Cs)and iodine(I)with high waste loadings and chemical durability.The perovskite Cs_(3)Bi_(2)I_(9)has high Cs(22 wt%)and I(58 wt%)content,and thus can be used as a potential host phase to immobilize these critical radionuclides.In this work,the perovskite Cs_(3)Bi_(2)I_(9)phase was synthesized by a cost effective solution-based approach,and was embedded into a highly durable hydroxyapatite matrix by spark plasma sintering to form dense ceramic composite waste forms.The chemical durabilities of the monolithic Cs_(3)Bi_(2)I_(9)and Cs_(3)Bi_(2)I_(9)-hydroxyapatite composite pellets were investigated by static and semi-dynamic leaching tests,respectively.Cs and I are incongruently released from the matrix for both pure Cs_(3)Bi_(2)I_(9)and composite structures.The normalized Cs release rate is faster than that of I,which can be explained by the difference in the strengths between Cs-I and Bi-I bonds as well as the formation of insoluble micrometer-sized BiOI precipitates.The activation energies of elemental releases based on dissolution and diffusion-controlled mechanisms are determined with significantly higher energy barriers for dissolution from the composite versus that of the monolithic Cs_(3)Bi_(2)I_(9).The ceramic-based composite waste forms exhibit excellent chemical durabilities and waste loadings,commensurate with the state-of-the-art glass-bonded perovskite composites for I and Cs immobilization. | Kun YANG Yachun WANG Junhua SHEN Spencer M.SCOTT Brian J.RILEY John D.VIENNA Jie LIAN | 2022 | Journal of Advanced Ceramics2022，11，5： | 0 |
| 16 | 采用Kalman滤波器的实时混合试验方法显示文摘等效力控制方法采用力反馈控制代替隐式积分方法中的迭代过程,从而使等效力控制方法在避免隐式积分方法的迭代过程的同时仍具有隐式积分方法的无条件稳定性。利用该力反馈控制,等效力控制方法还具有对实时子结构试验中的时滞进行补偿的作用。但是,在实际的实时子结构试验中,能够影响等效力控制方法时滞补偿效果的因素有很多,噪声就是其中之一。本文研究了噪声对等效力控制方法稳定性的影响。提高等效力PID控制器的比例增益可对系统时滞起到补偿作用,但是当比例增益较大时,等效力反馈中的噪声会降低等效力控制方法的稳定性。为了对等效力反馈中的噪声进行滤波,本文采用了基于作动器模型设计的Kalman滤波器,并通过实时子结构实验方法对其滤波效果进行研究。研究结果表明此滤波器能够有效地过滤噪声,消除噪声对等效力控制方法稳定性的影响。 | 史鹏飞 吴斌 Billie F. Spencer, Jr. Brian M. Phillips Chia-Ming Chang | 2011 | 结构工程师2011，27，B01： | 0 |
| 17 | Caveolin-1对乳腺癌细胞系MCF-7增殖和存活的影响显示文摘该文研究窖蛋白(Caveolin-1)对乳腺癌细胞系MCF-7细胞增殖与存活的影响。运用蛋白质印迹方法(Western blot)检测发现,caveolin-1在5株不同细胞系均只有低表达。运用电穿孔转染方法在乳腺癌细胞系中高表达Caveolin-1,运用Western blot检测转染后Caveolin-1表达情况发现,转染后细胞内Caveolin-1表达上升,并具有生物活性。运用单核细胞直接细胞毒性测定法(MTT)检测发现,转染后乳腺癌细胞系MCF-7增殖速度降低。运用Western blot方法和免疫荧光(immunofluorescence)方法检测转染后细胞凋亡途径的变化,磷酸化的P38蛋白含量上升,Bax表达量明显上升。据此推测Caveolin-1抑制MCF-7细胞的增殖和存活,并诱导基于Bax途径的细胞凋亡。 | 陆瑞盛 马骥 张燕 于玲莉 Ambre Spencer David Cluet Brian B.Rudkin 袁崇刚 | 2011 | 中国细胞生物学学报2011，33，9： | 0 |
| 18 | 温哥华公寓显示文摘温哥华公寓的建成预示着这个年轻的城市正在打开城市政策制定的新局面。它将成为从Granville大桥进入温哥华市中心的城市大门。塔楼和群房的设计是对新城市主义地域类型中的'温哥华主义'建筑的全新解读,配合一座纤细的塔楼,试图保留城市视觉通廊并激活步行通道。住宅塔楼借助高度和毗邻河流的地理位置,是唯一可以同时享受水景和山景的建筑,坐拥温哥华广袤的自然风光。 | Carl McDonald Melissa Bauld Aaron Mark Alan Tansey Alex Wu Alexandra Gustafsson Alina Tamosiunaite Amina Blacksher Aran Coakley Arash Adel Ahmadian Armen Menendian Barbora Srpkova Ben Zunkeler Benjamin Caldwell Benjamin Novacinski Bennett Gale Birk Daugaard Blake Theodore Smith Brian Foster Brian Rome Carolien Schippers Christopher James Malcolm Jr. Christopher Junkin Christopher Tron David Brown David Dottelonde Deborah Campbell Doug Stechschulte Douglass Alligood Edward Yung Elena Bresciani Filip Milovanovic Francesca Portesine Gabriel Hernandez Solano Gabriel Jewell-Vitale Hector Garcia Ivy Hume Jan Leenknegt Janice Rim John Kim Josiah Poland Julian Liang Julianne Gola Julie Kaufman Karol Bogdan Borkowski Kurt Nieminen Lauren Turner Lorenz Krisai Lucio Santos Marcella Martinez Martin Voelkle Matthew Dlugosz Megan Ng Michael Robert Taylor Otilia Pupezeanu Paula Domka Phillip MacDougall Ryan Yang Sean Franklin Sebastian Grogaard Simon Scheller Spencer Hayden Taylor Fulton Terrence Chew Terry Lallak Thomas Smith Tianqi Zhang Tobias Hjortdal Tran Le Valentina Mele Xinyu Wang Yaziel Juarbe Yoanna Shivarova Zach Walters Zhifei Xu Andrew Latreille Glotman Simpson Urban YVR 运小红(译) | 2019 | 城市环境设计2019，0，2： | 0 |
| 19 | 禽流感病毒和其他禽类病毒在环境中和胴体堆肥期间的生存显示文摘尽管禽流感、新城疫和其他重要的禽类病毒性疫病暴发过多次,但在面对疫病危机时,多把问题集中在环境中病毒的生存状况。文章阐述了温度、通风对病毒存活的影响,并对环境中和堆肥期间禽流感、新城疫等病毒的生存情况进行综述,供读者参考。 | J.Lloyd Spencer Jiewen Guan Brian W.Brooks 张培君 | 2007 | 中国家禽2007，29，20： | 0 |
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