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| 1 | Systematic review and meta-analysis on the association of tuberculosis in Crohn's disease patients treated with tumor necrosis factor-α inhibitors(Anti-TNFα)显示文摘AIM To perform a meta-analysis on the risk of developing Mycobacterium tuberculosis(TB) infection in Crohn's disease(CD) patients treated with tumor necrosis factoralpha(TNFα) inhibitors.METHODS A meta-analysis of randomized, double-blind, placebocontrolled trials of TNFα inhibitors for treatment of CD in adults was conducted. Arcsine transformation of TB incidence was performed to estimate risk difference. A novel epidemiologically-based correction(EBC) enabling inclusions of studies reporting no TB infection cases in placebo and treatment groups was developed to estimate relative odds.RESULTS Twenty-three clinical trial studies were identified, including 5669 patients. Six TB infection cases were reported across 5 studies, all from patients receiving TNFα inhibitors. Eighteen studies reported no TB infection cases in placebo and TNFα inhibitor treatment arms. TB infection risk was significantly increased among patients receiving TNFα inhibitors, with a risk difference of 0.028(95%CI: 0.0011-0.055). The odds ratio was 4.85(95%CI: 1.02-22.99) with EBC and 5.85(95%CI: 1.13-30.38) without EBC.CONCLUSION The risk of TB infection is higher among CD patients receiving TNFα inhibitors. Understanding the immunopathogenesis of CD is crucial, since using TNFα inhibitors in these patients could favor mycobacterial infections, particularly Mycobacterium avium subspecies paratuberculosis, which ultimately could worsen their clinical condition. | Brent L Cao Ahmad Qasem Robert C Sharp Latifa S Abdelli Saleh A Naser | 2018 | World Journal of Gastroenterology2018，24，25： | 4 |
| 2 | Resveratrol: isomeric molar absorptivities and stability显示文摘 | BRENT C | 1996 | Agric Food Chem1996，44，： | 1 |
| 3 | Methylation hot spots in the 5'flanking region denote silencing of the O6-methylguanine-DNA methyltrans-ferase gene显示文摘 | BRENT T P | 1997 | Cancer Res1997，57，17： | 1 |
| 4 | The modeling of heat, mass and solute transport in solidification systems显示文摘 | Voller V R Brent A D Prakash C | 1989 | International Journal of Heat and Mass Transfer1989，32，9： | 1 |
| 5 | An accumulation of negative life events and the construction of alexithymia:A longitudinal and clinical approach显示文摘 | de Tychey C Garnler S Lighezzolo-Alnot J Claudon P Rebourg-Roesler C & Brent D.A | | 0，，03： | 1 |
| 6 | Evalua- tion of railroad wheel steel with lamellar duplex microstruc- tures using diffuse ultrasonic backscatter显示文摘 | DU Hua-long LONSDALE C BRENT J O | 2013 | J Nondestruct Eval2013，32，4： | 1 |
| 7 | α4 integrin dependent leukocyte recruitment dose not require VCAM- 1 in a chronic model of inflammation显示文摘 | Brent Alex C Thomas BI | 2000 | Imm unol2000，164，1： | 1 |
| 8 | Removal of dissolved organic matter by nanofiltration显示文摘 | Amy Gary L Alleman Bruce C Cluff C Brent | 1990 | Journal of Environmental Engineering1990，116，1： | 1 |
| 9 | Inflammation, mieroglia, and Alzheimer's disease显示文摘 | Brent C Landreth GE | 2010 | Neurobiol Dis2010，37，3： | 1 |
| 10 | The Ganglia distributed monitoring system: design, implementation, and experience 显示文摘 | MATTEW L M BRENT N C DAVID E C | 2004 | Parallel Computing2004，30，7： | 1 |
| 11 | Optimal finite field multipliers for FPGAs 显示文摘 | Ahlquist Gregory C Nelson Brent Rice Michael | 2004 | Lecture Notes in Computer Science2004，1673，： | 1 |
| 12 | Application of the analytical hierarchy process to establish health care waste management systems that minimise infection risks in developing countries 显示文摘 | Alan C Brent David E C Rogers Tsaletseng S M Ramabitsa-Siimane Mark B Rohwer | 2007 | European Journal of Operational Research 1812007，，： | 1 |
| 13 | The Meaning and Measurement of Destination Image显示文摘 | Echtner C M J R Brent Ritchie | 1991 | Journal of Tourism Studies1991，2，2： | 1 |
| 14 | Model- ling the transition towards a green economy in South Africa 显示文摘 | Josephine K Musango Alan C Brent Andrea M Bassi | 2014 | Technological Forecasting & Social Change2014，，87： | 1 |
| 15 | The development of economical bipolar plates for fuel cells显示文摘 | Brent C Donald G B | 2006 | Journal of Materials Chemistry2006，16，： | 1 |
| 16 | Measurement and calculation of the two-dimensional backscattering Mueller matrix of a turbid medium显示文摘 | Brent D C Rakovic M J Mehrube Mehrubeglu | 1998 | Optics Letters1998，23，： | 1 |
| 17 | Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA-methyltransferase gene显示文摘 | Qian X C Brent T P | 1997 | Cancer Res1997，57，17： | 1 |
| 18 | Epiphytic microflora on alfalfa and whole-plant corn显示文摘 | Lin C Bolsen K K Brent B E | 1992 | J Dairy Sci1992，75，： | 1 |
| 19 | Effect of silage additives on the microbial succession and fermentation process of alfalfa and corn silages显示文摘 | Bolsen K K Lin C Brent B et aI | 1992 | Journal of Dairy Science1992，75，11： | 1 |
| 20 | The measurement of destination image : An empirical assessment 显示文摘 | Eehtner C M Brent Ritchie J R | 1993 | Journal of Travel Research1993，31，4： | 1 |
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