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| 1 | Total neoadjuvant therapy vs standard therapy of locally advanced rectal cancer with high-risk factors for failure显示文摘BACKGROUND For locally advanced rectal cancer(LARC),standard therapy[consisting of neoadjuvant chemoradiotherapy(CRT),surgery,and adjuvant chemotherapy(ChT)]achieves excellent local control.Unfortunately,survival is still poor due to distant metastases,which remains the leading cause of death among these patients.In recent years,the concept of total neoadjuvant treatment(TNT)has been developed,whereby all systemic ChT-mainly affecting micrometastases-is applied prior to surgery.AIM To compare standard therapy and total neoadjuvant therapy for LARC patients with high-risk factors for failure.METHODS In a retrospective study,we compared LARC patients with high-risk factors for failure who were treated with standard therapy or with TNT.High-risk for failure was defined according to the presence of at least one of the following factors:T4 stage;N2 stage;positive mesorectal fascia;extramural vascular invasion;positive lateral lymph node.TNT consisted of 12 wk of induction ChT with capecitabine and oxaliplatin or folinic acid,fluorouracil and oxaliplatin,CRT with capecitabine,and 6-8 wk of consolidation ChT with capecitabine and oxaliplatin or folinic acid,fluorouracil and oxaliplatin prior to surgery.The primary endpoint was pathological complete response(pCR).In total,72 patients treated with standard therapy and 89 patients treated with TNT were included in the analysis.RESULTS Compared to standard therapy,TNT showed a higher proportion of pCR(23%vs 7%;P=0.01),a lower neoadjuvant rectal score(median:8.43 vs 14.98;P<0.05),higher T-and N-downstaging(70%and 94%vs 51%and 86%),equivalent R0 resection(95%vs 93%),shorter time to stoma closure(mean:20 vs 33 wk;P<0.05),higher compliance during systemic ChT(completed all cycles 87%vs 76%;P<0.05),lower proportion of acute toxicity grade≥3 during ChT(3%vs 14%,P<0.05),and equivalent acute toxicity and compliance during CRT and in the postoperative period.The pCR rate in patients treated with TNT was significantly higher in patients irradiated with intensity-modulated radiotherapy/volumetricmodulated arc radiotherapy than with 3D conformal radiotherapy(32%vs 9%;P<0.05).CONCLUSION Compared to standard therapy,TNT provides better outcome for LARC patients with high-risk factors for failure,in terms of pCR and neoadjuvant rectal score. | Mojca Tuta Nina Boc Erik Brecelj Monika Peternel Vaneja Velenik | 2021 | World Journal of Gastrointestinal Oncology2021，13，2： | 3 |
| 2 | Operative stabilization of the remaining mobile segment in ankylosed cervical spine in systemic onset- juvenile idiopathic arthritis:A case report显示文摘We describe a case of a 19-year-old young man with oligoarthritis type of juvenile idiopathic arthritis, who presented with several month duration of lower neck pain and progressive muscular weakness of all four limbs. X-rays of the cervical spine demonstrated spontaneous apophyseal joint fusion from the occipital condyle to C6 and from C7 to Th2 with marked instability between C6 and C7. Surgical intervention began with anterolateral approach to the cervical spine performing decompression, insertion of cage and anterior vertebral plate and screws, followed by posterior approach and fixation. Care was taken to restore sagittal balance. The condition was successfully operatively managed with multisegmental, both column fixation and fusion, resulting in pain cessation and resolution of myelopathy. Postoperatively, minor swallowing difficulties were noted, which ceased after three days. Patient was able to move around in a wheelchair on the sixth postoperative day. Stiff neck collar was advised for three months postoperatively with neck pain slowly decreasing in the course of first postoperative month.On the follow-up visit six months after the surgery patient exhibited no signs of spastic tetraparesis, X-rays of the cervical spine revealed solid bony fusion at single mobile segment C6-C7. He was able to gaze horizontally while sitting in a wheelchair. Signs of myelopathy with stiff neck and single movable segment raised concerns about intubation, but were successfully managed using awake fiber-optic intubation. Avoidance of tracheostomy enabled us to perform an anterolateral approach without increasing the risk of wound infection. Regarding surgical procedure, the same principles are obeyed as in management of fracture in ankylosing spondylitis or Mb. Forestrier. | Lovro Suhodolcan Marko Mihelak Janez Brecelj Rok Vengust | 2016 | World Journal of Orthopedics2016，7，7： | 2 |
| 3 | Review on sedation for gastrointestinal tract endoscopy in children by non-anesthesiologists显示文摘AIM: To present evidence and formulate recommendations for sedation in pediatric gastrointestinal(GI) endoscopy by non-anesthesiologists.METHODS: The databases MEDLINE, Cochrane and EMBASE were searched for the following keywords 'endoscopy, GI', 'endoscopy, digestive system' AND 'sedation', 'conscious sedation', 'moderate sedation', 'deep sedation' and 'hypnotics and sedatives' for publications in English restricted to the pediatric age. We searched additional information published between January 2011 and January 2014. Searches for(upper) GI endoscopy sedation in pediatrics and sedation guidelines by non-anesthesiologists for the adult population were performed. RESULTS: From the available studies three sedation protocols are highlighted. Propofol, which seems to offer the best balance between efficacy and safety is rarely used by non-anesthesiologists mainly because of legal restrictions. Ketamine and a combination of a benzodiazepine and an opioid are more frequently used. Data regarding other sedatives, anesthetics and adjuvant medications used for pediatric GI endoscopy are also presented.CONCLUSION: General anesthesia by a multidisciplinary team led by an anesthesiologist is preferred. The creation of sedation teams led by non-anesthesiologists and a careful selection of anesthetic drugs may offer an alternative, but should be in line with national legislation and institutional regulations. | Rok Orel Jernej Brecelj Jorge Amil Dias Claudio Romano Fernanda Barros Mike Thomson Yvan Vandenplas | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，9： | 2 |
| 4 | 结直肠癌肝转移灶的电脉冲化疗显示文摘电脉冲化疗在许多皮肤肿瘤的治疗中发挥重要作用,并可应用至诸多深层肿瘤。为评估术中电脉冲化疗在结直肠癌肝转移治疗中的可行性、安全性和有效性,研究人员做了以下前瞻性研究。研究人员按照既定个性治疗方案,在开腹手术中将长针电极端插入肿瘤内部和周围,联合博来霉素行电脉冲化疗。研究人员对16位患者共29处肝转移灶行电脉冲化疗,未观察到术中及术后电脉冲化疗相关的严重不良反应。放射学评估显示,约85%转移灶完全缓解,而15%转移灶部分缓解。在行2次手术(第1次联合电脉冲化疗手术后6-12周)的7人组中发现,术中给予电脉冲化疗组的切除转移灶组织细胞学活性更弱。 | Edhemovic I Brecelj E Gasljevic G | 2014 | 中华结直肠疾病电子杂志2014，3，1： | 2 |
| 5 | Reduction of Metal Oxide Thin Layersby Hydrogen Plasma 显示文摘 | Brecelj F Mozetic M | 1990 | Vacuum1990，40，1： | 1 |
| 6 | Pattern ERG and VEP maturation in schoolchildren显示文摘 | Brecelj J Strucl M Zidar I | 2002 | Clin Neurophysiol2002，113，11： | 1 |
| 7 | From immature to mature pattern ERG and VEP显示文摘 | Jelka Brecelj | 2003 | Documenta Ophthalmologica2003，，3： | 1 |
| 8 | Optic neuritis in children--clinical and electrophysiological follow-up显示文摘 | Tekavcic-Pompe M Stirn-Kranjc B Brecelj J | 2003 | Doc Ophthalmol2003，107，： | 1 |
| 9 | Morphologi- cal and electrophysiological outcome in prospective in- travitreal bevacizumab treatment of macular edema sec- ondary to central retinal vein occlusion显示文摘 | Gardasevic Topcic I Utar M Brecelj J | 2014 | Documenta Ophthalmologica:Advances in Ophthalmology2014，129，1： | 1 |
| 10 | From immature to mature pattern ERG and VEP 显示文摘 | Brecelj J | 2003 | Doeumenta Ophthalmologiea2003，107，3： | 1 |
| 11 | ERG and VEP follow-up study in children with Lebers congenital amaurosis 显示文摘 | Brecelj J Stirn-Kranjc B | 1999 | Eye1999，13，1： | 1 |
| 12 | Chromatic visual evoked potentials in paediatric population显示文摘 | Pompe MT Kranjc BS Brecelj J | 2014 | Doc Ophthalmol2014，128，1： | 1 |
| 13 | Simultaneous pattern electro- retinogram and visual evoked potential recordings in dyslex- ic children显示文摘 | Brecelj J Strucl M Raic V | 1998 | Doc Ophthalmol1998，94，4： | 1 |
| 14 | Treatment of esophageal bile reflux in children:the results of a prospective study with omeprazole显示文摘 | Orel R Brecelj J Homan M | 2006 | J Pediatr Gastroenterol Nutr2006，42，4： | 1 |
| 15 | The effect of broadband and monochromatic stimuli on the photopic negative response of the electroretinogram in normal subjects and in open-angle glaucoma patients显示文摘 | Maja Sustar Barbara Cvenkel Jelka Brecelj | 2009 | Documenta Ophthalmologica2009，，3： | 1 |
| 16 | Visual electrophysiology in children with tumours affecting the visual pathway 显示文摘 | Brecelj J Stim-Kranjc B Skrbec M | 2000 | Doc Ophthalmol2000，101，： | 1 |
| 17 | Visual evoked magnetic response to central and peripheral stimulation:simultaneous VEP recordings 显示文摘 | Brecelj J Kakigi R Koyama S | 1998 | Brain Topogr1998，10，3： | 1 |
| 18 | The effect of broadband and monochromatic stimuli on the photopic negative response of the electroretinogram in normal subjects and in open-angle glaucoma patients显示文摘 | Maja Sustar Barbara Cvenkel Jelka Brecelj | 2009 | Documenta Ophthalmologica2009，，3： | 1 |
| 19 | From immature to mature pattern ERG and VEP 显示文摘 | Brecelj J | 2003 | Doc Ophthalmol2003，107，3： | 1 |
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