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| 1 | Associations of sense of coherence with psychological distress and quality of life in inflammatory bowel disease显示文摘AIM:To investigate the relationship between sense of coherence,psychological distress and health related quality of life in inflammatory bowel disease(IBD).METHODS:This cross-sectional study enrolled a consecutive sample of 147 IBD(aged 45.1 ± 14.1 years; 57.1% female) patients recruited from a tertiary gastroenterology service.Sixty-four participants met diagnostic criteria for Crohn's disease,while eightythree patients had ulcerative colitis.Socio-demographic data(education,age,race,gender,gross monthly income and marital status),disease-related variables(illness activity,relapse rate in past 2 years,history of surgery and time since diagnosis),sense of coherence(Antonovsky's SOC scale),psychological distress symptoms(Hospital Anxiety and Depression Scale) and health-related quality of life(HRQo L; WHOQOLBref) were assessed.Hierarchical multiple regression analyses were performed to identify factors that are independently associated with psychological distress and HRQo L in patients with IBD and to provide indications for possible moderating or mediating effects.In addition,formal moderation and mediation analyses(Sobel tests) were performed to confirm potential moderators/mediators of the relationship between SOC,psychological distress symptoms and HRQoL.RESULTS:Lower SOC scores(std beta=-0.504; P < 0.001),female gender(std beta = 0.176; P = 0.021) and White race(std beta = 0.164; P = 0.033) were independently associated with higher levels of depressive symptoms,while lower levels of SOC(std beta =-0.438; P < 0.001) and higher relapse rate(std beta = 0.161; P = 0.033) were independently associated with more severe anxiety symptoms.A significant interaction between time since diagnosis and SOC was found with regard to the severity of depressive or anxiety symptoms,as the interaction term(time since diagnosis X SOC) had beta coefficients of-0.191(P = 0.009) and-0.172(P = 0.026),respectively.Lower levels of anxiety symptoms(std beta =-0.369; P < 0.001),higher levels of SOC(std beta = 0.231; P = 0.016) and non-White race(std beta =-0.229; P = 0.006),i.e.,mixed-race,which represented the reference category,were independently associated with higher levels of overall HRQoL.Anxiety symptoms were the most potent independent correlate of most aspects of HRQoL.In addition,anxiety mediated the association between SOC and satisfaction with health,as well as its relationship with physical,mental,and social relations HRQo L.Depressive symptoms also mediated the association between SOC and mental HRQoL.CONCLUSION:Our data indicated that SOC is an important construct,as it influences psychological distress and has significant albeit indirect effects on several HRQoL domains in IBD. | Thiago H Freitas Elias Andreoulakis Gilberto S Alves Hesley LL Miranda Lúcia LBC Braga Thomas Hyphantis André F Carvalho | 2015 | World Journal of Gastroenterology2015，21，21： | 10 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | 石榴提取物抑制金黄色葡萄球菌的生长及其肠毒素产生显示文摘 | Braga L C 宋利萍(摘) 佟继铭(校) | 2006 | 国外医药(植物药分册)2006，21，1： | 3 |
| 4 | Postoperative enteral versus parenteral nutrition in malnourished patients with gastrointestinal cancer: a randomised multicentre trial显示文摘 | F Bozzetti M Braga L Gianotti C Gavazzi L Mariani | 2001 | The Lancet2001，，9292： | 2 |
| 5 | Immune and nutritional effects of early enteral nutrition after major abdominal operations显示文摘 | Braga M Vignali A Gianctti L | 1996 | Eur J Surg1996，162，2： | 1 |
| 6 | Postoperative enteral versus parenteral nutrition in malnourished patients with gastrointestinal cancer:a randomized multicentre trial显示文摘 | Bozzetti F Braga M Gianotti L | 2001 | Lancet2001，358，9292： | 1 |
| 7 | Revising concepts of artificial nutrition in contemporary surgery: from energy and nitrogen to immuno- metabolic support显示文摘 | Gianotti L Braga M | 2011 | Nutr Hosp2011，26，1： | 1 |
| 8 | Inflammatory Myofibroblastic Tumor of the Hepatobiliary System:Report of MR Imaging Appearance in Four Patients显示文摘 | Venkataraman S Semelka RC Braga L | | 0，，3： | 1 |
| 9 | Immune and nutlitionaeffects of early nutrition after major abdominal operations显示文摘 | Braga M Vignali A Gianotti L | 1996 | Eur J Surg1996，162，2： | 1 |
| 10 | Feeding the gut early after digestive surgery:results of a nine-year experience显示文摘 | Braga M Gianotti L Gentilini O | 2002 | Clin Nutr2002，21，1： | 1 |
| 11 | Postoperative enteral versus parenteral nutrition in malnourished patients with gastrointestinal cancer:a randomised multicentre trial显示文摘 | Bozzetti F Braga M Gianotti L | 2001 | Lancet2001，358，3： | 1 |
| 12 | Detection of fungi in beans by the laser biospeckle technique显示文摘 | Braga R A Rabelo G F Granato L R | 2005 | Biosystems Engineering2005，91，4： | 1 |
| 13 | Modern hepatic imaging 显示文摘 | Braga L Guller U Semelka RC | 2004 | Surg Clin North Am2004，84，2： | 1 |
| 14 | Primary realignment vssuprapubic cystostomy for the management of pelvic frac- ture-associated urethral injuries: a systematic review and meta- analysis显示文摘 | Barrett K Braga L H Farrokhyar F | 2014 | Urology2014，83，4： | 1 |
| 15 | Revising concepts of artificial nutrition incontemporary surgery: from energy and nitrogen to immunometabolicsupport显示文摘 | Gianotti L Braga M | 2011 | Nutr Hosp2011，26，1： | 1 |
| 16 | Postoperative enteral versus-parenteral nutriation in malnourished patients with gastrointestinal cancer : a randomized multicentre trial 显示文摘 | Bozzetti F Braga M Gianotti L | 2001 | Lancet2001，358，9292： | 1 |
| 17 | Early postoperative enteral nutrition improves gut oxygenation and reduces costs compared with total parenteral nutrition显示文摘 | Braga M Gianotti L Gentilini O | 2001 | Crit Care Med2001，29，： | 1 |
| 18 | Structural effects of WO3 incorporation on USY zeolite and applica- tion to free fatty acids esterification显示文摘 | Costa A A Braga P R S Macedo J L | 2012 | Microporous and Mesoporous Materials2012，147，1： | 1 |
| 19 | Composer-Science: a se- mantic service based framework for workflow composition in e-Sci- ence projects显示文摘 | da SILVA L M BRAGA R CAMPOS F | 2012 | Information Sciences2012，186，1： | 1 |
| 20 | The effect of the glucono-8-1actone/caseinate ratio on sodium caseinate gelation显示文摘 | BRAGA A L M MENOSSI M CUNHA R L | 2006 | International Dairy Journal2006，16，5： | 1 |
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