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1Inflammation and reactive oxygen species in cardiovascular disease显示文摘Reactive oxygen species(ROS)have long been proposed to be mediators of experimental cardiovascular pathology.There is also a wealth of data indicating that ROS are involved in clinical cardiovascular pathology.However,multiple clinical studies have shown little benefit from anti-oxidant treatments,whereas nearly all experimental studies have shown a marked effect of anti-oxidant therapy.One reason for this discrepancy is that ROS are produced through multiple different mechanisms of which some are clinically beneficial;thus,in a defined experimental system where predominately pathological ROS are generated does not mimic a clinical setting where there are likely to be multiple ROS generating systems producing beneficial and pathological ROS.Simple inhibition of ROS would not be expected to have the same result in these two situations;ergo,it is important to understand the molecular mechanism underlying the production of ROS so that clinical treatments can be tailored to target the pathological production of ROS.One such example of this in cardiovascular biology is tissue specific inflammation-mediated ROS generation.This and the following series of articles discuss the current understanding of the role of ROS in cardiovascular disease,specifically focusing on the molecular mechanisms of ROS generation and the actions of ROS within the cardiovascular system.Although there are still many areas with regard to the effects of ROS in the cardiovascular system that are not completely understood,there is a wealth of data suggesting that blocking pathological ROS production is likely to have beneficial clinical effects compared to traditional anti-oxidants.Bradley T Andresen 2010World Journal of Cardiology2010,2,12:5
2Hsp70 and a 54 kDa protein (Osp54) are induced in salmon (Salmo salar)in response to hyperosmotic stress 显示文摘Smith T R Tremblay G C Bradley T M 1999J Exp Zool1999,284,3:1
3The effects of uro- tensin ]I and urantide on forearm blood flow and systemic haemodynamics in humans 显示文摘Cheriyan J Burton T Bradley T 2009Br J Clin Pharmacol2009,68,4:1
4Factors influencing postoperative urinary retention in patients undergoing surgery for benign anoreetal disease显示文摘Petros J G Bradley T M 1994Am J Surg1994,159,4:1
5HIPI and HIPlr stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains显示文摘Hyun T S Rao D S Saint-Dic D Michael L E Kumar P D Bradley S V Mizukami I F 0,,14:1
6Analyzing product development task networks to examine organizational change显示文摘Collins S T Bradley J A Yassine A A 2010Engineering Management2010,57,3:1
7Improving Bystander Cardiopulmonary Resuscitation显示文摘Bradley S M Rea T D 2011Curr Opin Crit Care2011,17,3:1
8Stochastic simulation methods applied to a secure electronic voting model 显示文摘Bradley J T Gilmore S T 2006Electronic Notes in Theoretical Computer Science2006,151,3:1
9United States' International Retirement Migratian:The Reasons for Retiring to the Environs of Lake Chapala, Mexico 显示文摘Sunil T S Rojas V Bradley D E 2007Ageing and Society2007,27,4:1
10Radiographic imaging techniques for the diagnosisy of abnormal uterine Bleeding显示文摘Bradley LD Falcone T Magen AB 2000Obstet Gynecol Clin North Am2000,27,2:1
11Functionally separate intracellular Ca^2+ stores in smooth muscle 显示文摘Flynn E R Bradley K N Muir T C 2001J Biol Chem2001,276,36:1
12Use of microbial beta-lactamase to destroy penicillin added to milk显示文摘KORYCKA-DAHL M RICHARDSON T BRADLEY R L Jr 1985J Dairy Sci1985,68,8:1
13Inhibition of awake sympathetic nerve ac- tivity of heart failure patients with obstructive sleep apnea by nocturnal continu- ous positive airway pressure 显示文摘Usui K Bradley T Spaak J 2005J Am Coll Cardiol2005,45,:1
14Evidence for two independent domestication in cattle显示文摘LOFTUS R T MACHUGH D E BRADLEY D G 1994Proc Natl Acad Sci1994,91,:1
15Craniometric and Velopharyngeal Assessment of Infants With and Without Cleft Palate显示文摘Jamie L Perry David P Kuehn T Bradley P Sutton 0,,:1
16Environmental variability and climate change显示文摘Alverson K Bradley R Pedersen T 2001IGBP Science Series2001,3,:1
17Hypersensitivity to oxaliplatin: an investigation of incidence and risk factors, and literature review显示文摘Kim BH Bradley T Tai J 2009Oncology2009,76,:1
18Heavy Metal Stabilization in Municipal Solid Waste Combustion Bottom Ash Using Soluble Phosphate显示文摘Bradley S Crannell T Ttaylor Eighmy 2000Waste Management2000,20,:1
19Use of zirconit, m diboride-copper as an electrode in plasma applications 显示文摘Nomsetthekul S Eubank P T Bradley W L 1999Journal of Materials Science1999,34,:1
20IS Infrastructure : The Influence of Senior IT Leadership and Strategic Information Systems Planning 显示文摘Byrd T A Lewis B R Bradley R V 2006Journal of Computer Information Systems2006,47,1:1
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