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| 1 | Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression显示文摘Mass spectrometry(MS)-based omics technologies are now widely used to profile small molecules in multiple matrices to confer comprehensive snapshots of cellular metabolic phenotypes.The metabolomes of cells,tissues,and organisms comprise a variety of molecules including lipids,amino acids,sugars,organic acids,and so on.Metabolomics mainly focus on the hydrophilic classes,while lipidomics has emerged as an independent omics owing to the complexities of the organismal lipidomes.The potential roles of lipids and small metabolites in disease pathogenesis have been widely investigated in various human diseases,but system-level understanding is largely lacking,which could be partly attributed to the insufficiency in terms of metabolite coverage and quantitation accuracy in current analytical technologies.While scientists are continuously striving to develop high-coverage omics approaches,integration of metabolomics and lipidomics is becoming an emerging approach to mechanistic investigation.Integration of metabolome and lipidome offers a complete atlas of the metabolic landscape,enabling comprehensive network analysis to identify critical metabolic drivers in disease pathology,facilitating the study of interconnection between lipids and other metabolites in disease progression.In this review,we summarize omics-based findings on the roles of lipids and metabolites in the pathogenesis of selected major diseases threatening public health.We also discuss the advantages of integrating lipidomics and metabolomics for in-depth understanding of molecular mechanism in disease pathogenesis. | Raoxu Wang Bowen Li Sin Man Lam Guanghou Shui | 2020 | Journal of Genetics and Genomics2020，47，2： | 15 |
| 2 | Metabolomics through the lens of precision cardiovascular medicine显示文摘Metabolomics, which targets at the extensive characterization and quantitation of global metabolites from both endogenous and exogenous sources, has emerged as a novel technological avenue to advance the field of precision medicine principally driven by genomics-oriented approaches. In particular,metabolomics has revealed the cardinal roles that the environment exerts in driving the progression of major diseases threatening public health. Herein, the existent and potential applications of metabolomics in two key areas of precision cardiovascular medicine will be critically discussed: 1) the use of metabolomics in unveiling novel disease biomarkers and pathological pathways; 2) the contribution of metabolomics in cardiovascular drug development. Major issues concerning the statistical handling of big data generated by metabolomics, as well as its interpretation, will be briefly addressed. Finally, the need for integration of various omics branches and adopting a multi-omics approach to precision medicine will be discussed. | Sin Man Lam Yuan Wang Bowen Li Jie Du Guanghou Shui | 2017 | Journal of Genetics and Genomics2017，44，3： | 3 |
| 3 | Integration of high-performance spin-orbit torque MRAM devices by 200-mm-wafer manufacturing platform显示文摘We demonstrate in-plane field-free-switching spin-orbit torque(SOT)magnetic tunnel junction(MTJ)devices that are capable of low switching current density,fast speed,high reliability,and,most importantly,manufactured uniformly by the 200-mm-wafer platform.The performance of the devices is systematically studied,including their magnetic properties,switch-ing behaviors,endurance and data retention.The successful integration of SOT devices within the 200-mm-wafer manufactur-ing platform provides a feasible way to industrialize SOT MRAMs.It is expected to obtain excellent performance of the devices by further optimizing the MTJ film stacks and the corresponding fabrication processes in the future. | Hongchao Zhang Xiangyue Ma Chuanpeng Jiang Jialiang Yin Shuqin Lyu Shiyang Lu Xiantao Shang Bowen Man Cong Zhang Dandan Li Shuhui Li Wenjing Chen Hongxi Liu Gefei Wang Kaihua Cao Zhaohao Wang Weisheng Zhao | 2022 | Journal of Semiconductors2022，43，10： | 2 |
| 4 | Functional characterization of two ripening-related sucrose transporters from grape berries显示文摘 | Manning K Davies C Bowen H C | 2001 | Ann Bot2001，87，1： | 1 |
| 5 | Functional characterization of two ripening related sucrose transporters from grape berries显示文摘 | Manning K Dav ies C Bowen HC White PJ | 2001 | Ann Bot2001，84，： | 1 |
| 6 | Functional characterization of two ripening-related sucrose transporters from grape berries显示文摘 | Manning K Davies C Bowen HC | 2001 | Annals of Botany2001，87，： | 1 |
| 7 | Functional characterization of two ripening related sucrose transporters from grape berries 显示文摘 | Manning K Davies C Bowen H C | 2001 | Annals of Botany2001，87，： | 1 |
| 8 | Functional characterization of two ripening-related sucrose transporters from grape berries 显示文摘 | Manning K Davies C Bowen H C White P J | | Annals of Botany0，87，1： | 1 |
| 9 | Silver Products for Medical Indications: Risk-Benefit Assessment显示文摘 | Man C. Fung Debra L. Bowen | 1996 | Clinical Toxicology1996，，： | 1 |
| 10 | A proposal for the classification of sigma binding sites显示文摘 | Quirion R Bowen WD Itzhak Y Junien JL Musacchio JM Roth- man RB | 1992 | Trends Pharmacol Sci1992，13，3： | 1 |
| 11 | The Super-large Ensemble Experiments of CAS FGOALS-g3显示文摘A super-large ensemble simulation dataset with 110 members has been produced by the fully coupled model FGOALS-g3 developed by researchers at the Institute of Atmospheric Physics,Chinese Academy of Sciences.This is the first dataset of large ensemble simulations with a climate system model developed by a Chinese modeling center.The simulation has the largest realizations up to now worldwide in terms of single-model initial-condition large ensembles.Each member includes a historical experiment(1850-2014)and an experiment(2015-99)under the very high greenhouse gas emissions Shared Socioeconomic Pathway scenario(SSP5-8.5).The dataset includes monthly and daily temperature,precipitation,and other variables,requiring storage of 275 TB.Additionally,the surface air temperature(SAT)and land precipitation simulated by the FGOALS-g3 super-large ensemble have been validated and projected.The ensemble can capture the response of SAT and land precipitation to external forcings well,and the internal variabilities can be quantified.The availability of more than 100 realizations will help researchers to study rare events and improve the understanding of the impact of internal variability on forced climate changes. | Pengfei LIN Bowen ZHAO Jilin WEI Hailong LIU Wenxia ZHANG Xiaolong CHEN Jie JIANG Mengrong DING Wenmin MAN Jinrong JIANG Xu ZHANG Yuewen DING Wenrong BAI Chenyang JIN Zipeng YU Yiwen LI Weipeng ZHENG Tianjun ZHOU | 2022 | Advances in Atmospheric Sciences2022，39，10： | 0 |
| 12 | Lipidome Atlas of the Developing Heart Uncovers Dynamic Membrane Lipid Attributes Underlying Cardiac Structural and Metabolic Maturation显示文摘Precise metabolic rewiring during heart organogenesis underlies normal cardiac development.Herein,we utilized high-coverage,quantitative lipidomic approaches to construct lipidomic atlases of whole hearts(861 lipids;31 classes)and mitochondria(587 lipids;27 classes)across prenatal and postnatal developmental stages in mice.We uncovered the progressive formation of docosahexaenoyl-phospholipids and enhanced remodeling of C18:2,C20:3,and C20:4 fatty acyl moieties into cardiolipins as cardiac development progresses.A preferential flow of ceramides toward sphingomyelin biosynthesis over complex glycosphingolipid formation was also noted.Using maSigPro and GPclust algorithms,we identified a repertoire of 448 developmentally dynamic lipids and mapped their expression patterns to a library of 550 biologically relevant developmentally dynamic genes.Our combinatorial transcriptomics and lipidomics approaches identified Hadha,Lclat1,and Lpcat3 as candidate molecular drivers governing the dynamic remodeling of cardiolipins and phospholipids,respectively,in heart development.Our analyses revealed that postnatal cardiolipin remodeling in the heart constitutes a biphasic process,which first accumulates polyunsaturated C78-cardiolipins prior to tetralinoleoyl cardiolipin forming the predominant species.Multiomics analyses supplemented with transmission electron microscopy imaging uncovered enhanced mitochondria–lipid droplet contacts mediated by perilipin-5.Our combinatorial analyses of multiomics data uncovered an association between mitochondrial-resident,docosahexaenoic acid-phospholipids and messenger RNA levels of proton-transporting adenosine triphosphate synthases on inner mitochondrial membranes,which adds credence to the membrane pacemaker theory of metabolism.The current findings offer lipid-centric biological insights potentially important to understanding the molecular basis of cardiac metabolic flexibility and disease pathology. | Huan Miao Bowen Li Zehua Wang Jinming Mu Yanlin Tian Binhua Jiang Shaohua Zhang Xia Gong Guanghou Shui Sin Man Lam | 2023 | Research2023，，3： | 0 |
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