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| 1 | Hepatitis B virus reactivation in hepatitis B virus surface antigen negative patients receiving immunosuppression: A hidden threat显示文摘AIM: To present the characteristics and the course of a series of anti- hepatitis B virus core antibody (HBc) antibody positive patients, who experienced hepatitis B virus (HBV) reactivation after immunosuppression. METHODS: We retrospectively evaluated in our tertiary centers the medical records of hepatitis B virus surface antigen (HBsAg) negative patients who suffered from HBV reactivation after chemotherapy or immunosuppression during a 3-year period (2009-2011). Accordingly, the clinical, laboratory and virological characteristics of 10 anti-HBc (+) anti-HBs (-)/HBsAg (-) and 4 anti-HBc (+)/antiHBs (+)/HBsAg (-) patients, who developed HBV reactivation after the initiation of chemotherapy or immunosuppressive treatment were analyzed. Quantitative determination of HBV DNA during reactivation was performed in all cases by a quantitative real time polymerase chain reaction kit (COBAS Taqman HBV Test; cut-off of detection: 6 IU/mL). RESULTS: Twelve out of 14 patients were males; median age 74.5 years. In 71.4% of them the primary diagnosis was hematologic malignancy; 78.6% had received rituximab (R) as part of the immunosuppressive regimen. The median time from last chemotherapy schedule till HBV reactivation for 10 out of 11 patients who received R was 3 (range 2-17) mo. Three patients (21.4%) deteriorated, manifesting ascites and hepatic encephalopathy and 2 (14.3%) of them died due to liver failure. CONCLUSION: HBsAg-negative anti-HBc antibody positive patients can develop HBV reactivation even 2 years after stopping immunosuppression, whereas prompt antiviral treatment on diagnosis of reactivation can be lifesaving. | Kalliopi Zachou Alexandros Sarantopoulos Nikolaos K Gatselis Themistoklis Vassiliadis Stella Gabeta Aggelos Stefos Asterios Saitis Panagiota Boura George N Dalekos | 2013 | World Journal of Hepatology2013，5，7： | 6 |
| 2 | Effects of amitriptyline on gastric scnsorimotor function and postprandial symptoms in healthy individuals: a randomized, double-blind, placebo-con- trolled trial显示文摘 | Bouras EP Talley N J Camilleri M | 2008 | Am J Gastroentcrol2008，103，8： | 1 |
| 3 | Nutritional requirements for the production of dithiolopyrrolone antibiotics by Saccharothrix algeriensis NRRL B-24137显示文摘 | Bouras N Mathieu F Sabaou N | 2006 | Enzyme and Microbial Technology2006，39，： | 1 |
| 4 | Myeloperoxidase:expressing inflammation and oxidative stress in cardiovascular disease显示文摘 | Anatoliotakis N Deftereos S Bouras G | 2013 | Curr Top Med Chem2013，13，2： | 1 |
| 5 | Microstructure and physical properties of nanofaceted antimony doped tin oxide thin films deposited by chemical vapor deposition on different substrates显示文摘 | Outemzabet R Bouras N Kesri N | 2007 | Thin Solid Films2007，515，6： | 1 |
| 6 | Human mesenchymal stem cells from the umbilical cord matrix: Successful isolation and ex vivo expan- sion using serum -/xeno - free culture media显示文摘 | SIMOES I N BOURA J S DOS SANTOS F | 2013 | Biotechnol J2013，8，： | 1 |
| 7 | Applica-tion layer forward error correction for multicast stream-ing over LTE networks显示文摘 | Bouras C Kanakis N Kokkinos V | | 0，，11： | 1 |
| 8 | Microstructure and physical properties of nanofaceted antimony doped tin oxide thin films deposited by chemical vapor deposition on different substrates显示文摘 | Outemzahet R Bouras N Kesri N | 2007 | Thin Solid Films2007，515，： | 1 |
| 9 | Conformal therapy of locally advanced cholangiocarcinoma of the main bile ducts显示文摘 | Bouras N Caudry M Saric J | 2002 | Cancer Radiother2002，6，1： | 1 |
| 10 | Liver regeneration after hepatectomy显示文摘 | Kountouras J Boura P Lygidakis N J | 2001 | Hepatogastroenterology2001，48，： | 1 |
| 11 | Conformal therapy of locally advanced cholangiocarcinoma of the main bile ducts显示文摘 | Bouras N Caudry M Saric J | 2002 | Cancer Radiother2002，6，1： | 1 |
| 12 | Myeloperoxidase: expressing inflammation and oxidative stress in cardiovascular disease显示文摘 | Anatoliotakis N Dettereos S Bouras G | 2013 | Curr Top Med Chem2013，13，2： | 1 |
| 13 | I mmunopathogenie mecha-nisms in hypertension 显示文摘 | Lefkos N Boura P Boudonas G | 1995 | Am J Hypertens1995，70，8： | 1 |
| 14 | Myeloperoxidase : Expressing Inflammation and Oxidative Stress in Cardiovascular Disease显示文摘 | Anatoliotakis N Deflereos S Bouras G | 2013 | Curr Top Med Chem2013，13，2： | 1 |
| 15 | Responsive Cementing Material Prevents Annular Leaks in Gas Wells 显示文摘 | Bouras H Doumaz N Sonatrach | | SPE0，，： | 1 |
| 16 | Liver regeneration after hepatectomy显示文摘 | Kountouras J Boura P Lygidakis N J | 2001 | Hepatogastroenterology2001，48，： | 1 |
| 17 | Effects of amitriptyline on gastric sensorimotor function and postprandial symptoms in healthy individuals: a randomized, double-blind, placebocontrolled trial 显示文摘 | Bouras EP Talley N Camilleri M et at | 2008 | Am J Gastroentero12008，103，： | 1 |
| 18 | Effect of amino acids containing sulfur on dithiolopyrrolone antibiotic productions by Saccharothrix algeriensis NRRL B-24137显示文摘 | Bouras N Mathieu F Sabaou N | | 0，，02： | 1 |
| 19 | Myeloperoxidase: expressing inflammation and oxidative stress in cardiovascu- lar disease 显示文摘 | Anatoliotakis N Deftereos S Bouras G | 2013 | Curt Top Med Chem2013，13，2： | 1 |
| 20 | Oral ingestion of lactic-acid bacteria by rats increases lymphocyte proliferation and interferon-gamma production显示文摘 | Aattour N Bouras M Tome D | 2002 | Br J Nutr2002，87，4： | 1 |
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