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| 1 | Requirement and Development of Hydrogel Micromotors towards Biomedical Applications显示文摘With controllable size,biocompatibility,porosity,injectability,responsivity,diffusion time,reaction,separation,permeation,and release of molecular species,hydrogel microparticles achieve multiple advantages over bulk hydrogels for specific biomedical procedures.Moreover,so far studies mostly concentrate on local responses of hydrogels to chemical and/or external stimuli,which significantly limit the scope of their applications.Tetherless micromotors are autonomous microdevices capable of converting local chemical energy or the energy of external fields into motive forces for self-propelled or externally powered/controlled motion.If hydrogels can be integrated with micromotors,their applicability can be significantly extended and can lead to fully controllable responsive chemomechanical biomicromachines.However,to achieve these challenging goals,biocompatibility,biodegradability,and motive mechanisms of hydrogel micromotors need to be simultaneously integrated.This review summarizes recent achievements in the field of micromotors and hydrogels and proposes next steps required for the development of hydrogel micromotors,which become increasingly important for in vivo and in vitro bioapplications. | Xinyi Lin Borui Xu Hong Zhu Jinrun Liu Alexander Solovev Yongfeng Mei | 2020 | Research2020，，1： | 2 |
| 2 | Numerical and Experimental Investigations of the Thermal Fatigue Lifetime of CBGA Packages显示文摘A thermal fatigue lifetime prediction model of ceramic ball grid array(CBGA)packages is proposed based on the Darveaux model.A finite element model of the CBGA packages is established,and the Anand model is used to describe the viscoplasticity of the CBGA solder.The average viscoplastic strain energy density increment △Wave of the CBGA packages is obtained using a finite element simulation,and the influence of different structural parameters on theWave is analyzed.A simplified analytical model of the △Wave is established using the simulation data.The thermal fatigue lifetime of CBGA packages is obtained from a thermal cycling test.The Darveaux lifetime predictionmodel ismodified based on the thermal fatigue lifetime obtained fromthe experiment and the corresponding △Wave.A validation test is conducted to verify the accuracy of the thermal fatigue lifetime prediction model of the CBGA packages.This proposed model can be used in engineering to evaluate the lifetime of CBGA packages. | Borui Yang Jun Luo Bo Wan Yutai Su Guicui Fu Xu Long | 2022 | Computer Modeling in Engineering & Sciences2022，，2： | 1 |
| 3 | Temperature-dependent optical resonance in a thin-walled tubular oxide microcavity显示文摘This work proposes a temperature-response capability of optical resonance in tubular optical oxide microcavities. The thin wall thickness with a subwavelength scale enables these microcavities to interact with the environment effectively. By optimization of the geometries and materials, the tubular microcavities can be tuned into temperature-inert in vacuum, and the experiments support this design. The experiments prove the idea of utilizing them as temperature-inert microcavities. Contrary wavelength shifts from previous studies were observed, which can be explained with the theoretical model. Furthermore, the theoretical results of the present work suggest that novel rolled-up microtubes could act as an exceptional optical microcavity for the application in temperature response. | Yangfu Fang Xianyun Lin Shiwei Tang Borui Xu Jiao Wang Yongfeng Mei | 2017 | Progress in Natural Science:Materials International2017，27，4： | 1 |
| 4 | Shape Memory Alloy Helical Microrobots with Transformable Capability towards Vascular Occlusion Treatment显示文摘Practical implementation of minimally invasive biomedical applications has been a long-sought goal for microrobots.In this field,most previous studies only demonstrate microrobots with locomotion ability or performing a single task,unable to be functionalized effectively.Here,we propose a biocompatible shape memory alloy helical microrobot with regulative structure transformation,making it possible to adjust its motion behavior and mechanical properties precisely.Especially,towards vascular occlusion problem,these microrobots reveal a fundamental solution strategy in the mechanical capability using shape memory effect.Such shape-transformable microrobots can not only manipulate thrust and torque by structure to enhance the unclogging efficiency as a microdriler but also utilize the high work energy to apply the expandable helical tail as a selfpropulsive stent.The strategy takes advantage of untethered manipulation to operate microsurgery without unnecessary damage.This study opens a route to functionalize microrobots via accurate tuning in structures,motions,and mechanical properties. | Hehua Zhang Borui Xu Yi Ouyang Yunqi Wang Hong Zhu Gaoshan Huang Jizhai Cui Yongfeng Mei | 2022 | Research2022，，4： | 1 |
| 5 | Therapeutic application of chick early amniotic fluid: effective rescue of acute myocardial ischemic injury by intravenous administration显示文摘Myocardial regeneration has been considered a promising option for the treatment of adult myocardial injuries.Previously,a chick early amniotic fluid(ceAF)preparation was shown to contain growth-related factors that pro-moted embryonic growth and cellular proliferation,though the nature of the components within ceAF were not fully defined.Here we tested whether this ceAF preparation is similarly effective in the promotion of myocardial regen-eration,which could provide an alternative therapeutic for intervening myocardial injury.In this study,a myocardial ischemic injury model was established in adult mice and pigs by multiple research entities,and we were able to show that ceAF can efficiently rescue damaged cardiac tissues and markedly improve cardiac function in both experimental models through intravenous administration.ceAF administration increased cell proliferation and improved angio-genesis,likely via down-regulation of Hippo-YAP signaling.Our data suggest that ceAF administration can effectively rescue ischemic heart injury,providing the key functional information for the further development of ceAF for use in attenuating myocardial injury. | Baiping Cui Yufan Zheng Xiang Gao Lihong Zhang Borui Li Jia Chen Xinyan Zhou Mengyuan Cai Wenrui Sun Yuting Zhang Keejong Chang Jiayi Xu Fuyin Zhu Yan Luo Tao Sun Jin Qian Ning Sun | 2022 | Cell Regeneration2022，11，1： | 0 |
| 6 | A 10-Year Retrospective Cohort Study of Real-World Effectiveness of Sofosbuvir-Based Regimens for Hepatitis C in a Single Center in China显示文摘This study aimed to review the trends of hepatitis C virus(HCV)treatment over the past decade and to analyze the effectiveness of sofosbuvir(SOF)–based direct-acting antiviral regimens in the heterogeneous population of patients with chronic hepatitis C(CHC)in clinical practice.This retrospective cohort study included CHC patients attending the Sir Run Run Shaw Hospital between January 1,2012,and December 31,2022.All of the 194 patients treatedwith SOF-based regimens completed 12weeks of treatment and were followed up for at least 12 weeks after completion of the therapy.Sustained virologic response(SVR)12 weeks after the end of treatment was the primary endpoint.A total of 194 patients treated with SOF-based regimens were included,among which 121,56,10 and 7 patients received SOF+velpatasvir±ribavirin,SOF+daclatasvir,SOF+ledipasvir or SOF+ribavirin,respectively.With 36.1%,HCV Genotype 1 predominated in CHC patients treated with SOF-based regimens,followed by Genotype 2a with 17.5%and Genotype 3 with 14.9%.Comorbidities among patients included hypertension(4.1%),diabetes(2.1%),depression(1.0%)and neoplastic disease(2.6%).All patients treated with SOF-based regimens achieved SVR.There was no association between SVR and factors such as HCV genotype,sex,age,presence of cirrhosis or previous treatment history.There were no reports of any serious adverse events in the study.This single-center retrospective study represented the latest 10-year treatment trends for HCV in real-world clinical practice and provided useful information on the excellent efficacy of SOF-based direct-acting antiviral regimens for treatment of CHC patients in Eastern China. | Qiao Yang Fangping Xu Yi Shen Borui Pi Fangfang Lv | 2023 | Infectious Microbes & Diseases2023，5，4： | 0 |
| 7 | Tubular micro/nanoengines: boost motility in a tiny world显示文摘Since 20th century,the development of rocket science has put forward to the dream of humankind that one day we can reach other planets except for observing them through telescope.The rockets get rid of gravity by a powerful engine,consuming chemical fuel to generate a vast thrust.Inspired by rockets and motors in macroscale,researchers on nanoscience and nanotechnology are able to construct engines which can carry and transport cargos | Borui Xu Yongfeng Mei | 2017 | Science Bulletin2017，62，8： | 0 |
| 8 | Diffusion-weighted imaging and variable flip angle T1 mapping: a supplement for image-guided biopsy in follow-up analysis of liver fibrosis显示文摘Purpose To evaluate the performance of diffusion-weighted imaging(DWI) and variable flip angle(VFA) T1 mapping as a supplement to image-guided biopsy in follow-up analysis of liver fibrosis. Materials and Methods This prospective study was approved by the institution's committee on human research, and written informed consent was provided from the enrolled patients. We investigated five MRI parameters of DWI and VFA T1 mapping, collected from 11 patients who underwent serial ultrasound image-guided biopsy with follow-up MRI within 1.5 years after treatment for liver fibrosis/cirrhosis. For each patient, four consecutive MRI examinations were conducted, including baseline MRI before treatment and three follow-up MRI examinations after treatment at each 0.5-year interval. ADC values at four b values and T1 relaxation times were correlated to pathology-confirmed liver fibrosis stages, which were subsequently divided into two groups, stages F2–3 and F4. The receiver operating characteristic(ROC) analysis and repeated measurement analysis of variance were used for statistical analysis. Results Among these ADC parameters, ADC value(b = 500 s/mm^2) was the most consistent in differentiating between stage F2–3 and F4 liver fibrosis. Repeated measurement analysis showed that the intra-group and inter-group differences were 0.447 and 0.024, respectively. T1 relaxation time could not consistently differentiate between the F2–3 and F4 groups; however, it was repeatable, and the intra-group and inter-group differences were 0.410 and 0.042, respectively. Conclusion MRI-ADC value at a b value of 500 s/mm^2 can be a promising biomarker for differentiating stages F2–3 and F4 liver fibrosis. A combination of this biomarker with repeatable T1 relaxation time may function as a non-invasive tool for follow-up liver fibrosis in patients who reject repeated image-guided biopsy. | Peng Hu Jihong Sun Fangfang Lv Borui Pi Fangping Xu Guocan Han Xi Hu Yue Wang Ning Huang Xia Wu Xiaoming Yang | 2018 | Journal of Interventional Medicine2018，1，3： | 0 |
| 9 | Rolling origami with smart materials显示文摘Three-dimensional (3D) functional devices have become an interesting topic meeting the challenge of device miniaturization and high integration in electron devices and microelectromechanical systems. Based on this exciting situation, origami in micro/nanoscale combining art and advanced science was widely utilized to transform two-dimensional (2D) sheets into 3D microstructures for various applications, such as micro-grippers [1](Fig. 1a). | Yang Wang Xing Li Borui Xu Ziao Tian Zengfeng Di Yongfeng Mei | 2019 | Science Bulletin2019，64，15： | 0 |
| 10 | Development Strategy and Countermeasures of China's CBM Industry under the Goal of “Carbon Peak and Neutrality”显示文摘China’s coalbed methane(CBM) industry is in an extremely important “climbing period” and “strategic opportunity period”,which can be generally characterized by “three low and one small”:low degree of exploration and development,low adaptability of main technology,low return on investment and small development scale.Under the “carbon peak and neutrality” background,the development status of CBM industry is systematically combed.The resources,technology,management problems and reasons are analyzed.Strategies and countermeasures to accelerate the industrial development are put forward according to the factors such as efficient development of resources,major technical breakthrough,talent team training,policy formulation and implementation,return on investment and so on.The existing problems are as follows:(a) The overall occurrence conditions in China are complicated and the development is difficult compared with the other countries.(b) The research precision accuracy of CBM resource conditions is not enough.(c) The adaptability of technology is poor.(d) The management mode is not suitable.In view of these problems,this paper puts forward the “two steps” development strategy and the technical and management countermeasures of “five in one”.The corresponding “five in one” technology and management countermeasures are the formulation and implementation of relevant safeguard measures in accordance with the principle of collaborative innovation in five aspects:resources,technology,talents,policies and investment.Through the above measures,the dream and grand blueprint of CBM industry shall be realized. | Fengyin Xu Xia Yan Fenglin Wang Xinyuan Ma Jian Yun Hongna Wang Borui Xu Shuangyuan Zhang Delei Mao | 2023 | Journal of Earth Science2023，34，4： | 0 |
| 11 | The status and development strategy of coalbed methane industry in China显示文摘To achieve the goals of carbon peaking and carbon neutrality under the backgrounds of poor resource endowments, weak theoretical basis and other factors, the development of the coalbed methane industry of China faces many bottlenecks and challenges. This paper systematically analyzes the coalbed methane resources, key technologies and progress, exploration effect and production performance in China and abroad. The main problems are summarized as low exploration degree, low technical adaptability, low return on investment and small development scale. This study suggests that the coalbed methane industry in China should follow the “two-step”(short-term and long-term) development strategy. The short-term action before 2030, can be divided into two stages:(1) From the present to 2025, to achieve new breakthroughs in theory and technology, and accomplish the target of annual production of 10 billion cubic meters;(2) From 2025 to 2030, to form the technologies suitable for most geological conditions, further expand the industry scale, and achieve an annual output of 30 billion cubic meters, improving the proportion of coalbed methane in the total natural gas production. The long-term action after 2030 is to gradually realize an annual production of 100 billion cubic meters. The strategic countermeasure to achieve the above goals is to adhere to “technology+management dual wheel drive”, realize the synchronous progress of technology and management, and promote the high-quality development of the coalbed methane industry. Technically, the efforts will focus on fine and effective development of coalbed methane in the medium to shallow layers of mature fields, effective development of coalbed methane in new fields, extensive and beneficial development of deep coalbed methane, three-dimensional comingled development of coalbed methane, applying new technologies such as coalbed methane displacement by carbon dioxide, microwave heating and stimulation technology, ultrasonic stimulation, high-temperature heat injection stimulation, rock breaking by high-energy laser. In terms of management, the efforts will focus on coordinative innovation of resource, technology, talent, policy and investment, with technological innovation as the core, to realize an all-round and integrated management and promote the development of coalbed methane industry at a high level. | XU Fengyin HOU Wei XIONG Xianyue XU Borui WU Peng WANG Hongya FENG Kun YUN Jian LI Shuguang ZHANG Lei YAN Xia FANG Huijun LU Qian MAO Delei | 2023 | Petroleum Exploration and Development2023，50，4： | 0 |
| 12 | Nanomembrane folding origami:Geometry control and micro-machine applications显示文摘Three-dimensional(3D)microstructures have important applications in a wide range of engineering fields.A strategy of nanomembrane folding origami with microdroplet-guided intercalation and strain engineering to construct complex 3D microstructures for micro-machine applications is proposed in the present investigation.The results showed that nanomembranes were released by the microdroplet intercalation and subsequently fold up as creases,or remain flat as facets,depending on the strain design configurations.The 3D geometry can be controlled by the crease design and by an externally applied magnetic field.Moreover,this folding strategy is used to construct magnetic micro-mirror arrays,magnetic micro-robots,and a twin-jet motor platform,showing potential micro-machine applications in optical micro-devices and robotics.This strategy offers a simple,precise,and designable method of folding 3D microstructures for fundamental research and practical applications. | Yang Zong Xinyuan Zhang Yue Wu Yang Wang Chang Liu Borui Xu Gaoshan Huang Jizhai Cui Yongfeng Mei | 2021 | Progress in Natural Science:Materials International2021，31，6： | 0 |
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