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209篇 您的检索式：作者名="Boonstra A"

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	题名	作者	年代	出处	被引量
1	ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients显示文摘AIM:To investigate if the presence of relevant genetic polymorphisms has effect on the effectual clearance of bacteria by monocytes and granulocytes in patients with Crohn’s disease(CD).METHODS:In this study,we assessed the differential responses in phagocytosis by measuring the phagocytic activity and the percentage of active phagocytic monocytes and granulocytes in inflammatory bowel disease patients as well as healthy controls.As both autophagy related like 1(ATG16L1)and immunityrelated guanosine triphosphatase gene are autophagy genes associated with CD and more recently nucleo-tide-binding ligomerization domain-containing protein2(NOD2)has been identified as a potent inducer of autophagy we genotyped the patients for these variants and correlated this to the phagocytic reaction.The genotyping was done with restriction fragment length polymorphisms analysis and the phagocytosis was determined with the pHrodo?Escherichia coli Bioparticles Phagocytosis kit for flowcytometry.RESULTS:In this study,we demonstrate that analysis of the monocyte and granulocyte populations of patients with CD and ulcerative colitis showed a comparable phagocytic activity(ratio of mean fluorescence intensity)between the patient groups and the healthy controls.CD patients show a significantly higher phagocytic capacity(ratio mean percentage of phagocytic cells)compared to healthy controls(51.91%±2.85%vs 37.67%±7.06%,P=0.05).The extend of disease was not of influence.However,variants of ATG16L1(WT:2.03±0.19 vs homozygoot variant:4.38±0.37,P<0.009)as well as NOD2(C-ins)(heterozygous variant:42.08±2.94 vs homozygous variant:75.58±4.34(P=0.05)are associated with the phagocytic activity in patients with CD.CONCLUSION:Monocytes of CD patients show enhanced phagocytosis associated with the presence of ATG16L1 and NOD2 variants.This could be part of the pathophysiological mechanism resulting in the disease.	Simone CS Wolfkamp Caroline Verseyden Esther WM Vogels Sander Meisner Kirsten Boonstra Charlotte P Peters Pieter CF Stokkers Anje A te Velde	2014	World Journal of Gastroenterology2014，20，10：	2
2	显示文摘	Barat FJ Cua D J Boonstra A	2002	J Exp Med2002，195，：	1
3	Characterisation of thermally modfied wood: molecular reasons for wood performance improvement显示文摘	Tjeerdsma BF Boonstra M Pizzi A	1998	Holz als Roh-Und Werkstoff1998，56，3：	1
4	The influence of the pretrestment of powder on the resulting properties of LaNi5 electrodes显示文摘	Boonstra A H Bernards T M N	1990	J Less Common Metals1990，161，2：	1
5	The impact of predator-induced strees in the snowshoe hare cycles 显示文摘	Boonstra R Hik D Singleton G R Tinnikov A	1998	Ecology Monographs1998，79，5：	1
6	1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells显示文摘	Boonstra A Barrat F J Crain C	2001	J Immunol2001，167，9：	1
7	Cofactor regeneration by a soluble pyridine nucleotide transhydrogenase for biological production of hydromorphone 显示文摘	Boonstra B Rathbone D A	2000	Appl Environ Microbiol2000，66，12：	1
8	1 alpha,25 -Dihydroxyvitamin D has a direct effect on naive CD ~ T cells to enhance the develop- ment of Th2 cells显示文摘	Boonstra A Barrat FJ Crain C	2001	J lmmunol2001，167，9：	1
9	Cell fate determination during G1 phase progression显示文摘	BLOMEN V A BOONSTRA J	2007	Cell Mol Life Sci2007，64，23：	1
10	1,25-Dihydroxyvitamin D3 has a direct effect on naive CD4+ T cells to enhance The development of TH2 cells显示文摘	Boonstra A Barrat FJ Crain C	2001	J Immunol2001，167，9：	1
11	Exercise testing to estimate survival in pulmonary hypertension 显示文摘	Groepenhoff H Vonk-Noordegraaf A Boonstra A	2008	Med Sci Sports Exerc2008，40，：	1
12	Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology显示文摘	Asselin-paturel C Boonstra A Dalod M	2001	Nat Immunol2001，2，12：	1
13	The role of cytokines in uhraviolet-- B induced immunosuppression显示文摘	Boonstra A Savelkonl H	1997	Eur Cytokine Netw1997，8，2：	1
14	Flexibility of mouse classical and plasmacytoid-derived dendritic Cells in directing T helper type 1 and 2 cell development:dependency on antigen dose and differential toll-like receptor ligation显示文摘	Boonstra A Asselin Paturel C Gilliet M	2003	J Exp Med2003，197，1：	1
15	lalpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4 ~ T ceils to enhance the development of Th2 cells 显示文摘	Boonstra A Barrat FJ Crain C	2001	J Immunol2001，167，9：	1
16	In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1) -and Th2-inducing cytokines显示文摘	Barrat FJ Cua DJ Boonstra A	2002	J Exp Med2002，195，5：	1
17	In vitro generation of interleukin l O-producing regulatory CD4 T cells is induced by immunosuppressive drugs and inhibited by T helper type 1(Th1)- and Th2-inducing cytokines 显示文摘	Barrat FJ Cua DJ Boonstra A	2002	J Exp Med2002，195，5：	1
18	Array signal pro- cessing for radio astronomy显示文摘	VEEN A LESHEM A BOONSTRA A	2004	Experimental Astronomy2004，17，1：	1
19	Analysis of chromosomal copy number changes and oncoprotein expression in primary central nervous system lymphomas:frequent loss of chromosome arm 6q显示文摘	Boonstra R Koning A Mastik M	2003	Virchows Arch2003，443，2：	1
20	The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/ macrophage colony-stimulating factor显示文摘	Gilliet M Boonstra A Paturel C		Journal of Experimental Medicine0，，：	1

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