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| 1 | Differing profiles of people diagnosed with acute and chronic hepatitis B virus infection in British Columbia,Canada显示文摘AIM To describe the characteristics of people diagnosed with acute and chronic hepatitis B virus(HBV) infection in British Columbia(BC).METHODS We used data from the BC Hepatitis Testers Cohort(BCHTC),which includes all individuals tested for hepatitis C virus(HCV) or human immunodeficiency virus(HIV) or those diagnosed with HBV or active tuberculosis in BC since 1990.These data were integrated with prescription drug,medical visit,hospitalization and mortality data.HBV cases were classified as acute or chronic according to provincial guidelines.We compared characteristics of individuals by HBV infection group(acute,chronic and negative).Factors associated with acute or chronic HBV infection were assessed with multinomial logistic regression models in comparison to the HBV negative group.RESULTS46498 of the 1058056 eligible BC-HTC participants were diagnosed with HBV infection.4.3% of HBV positive individuals were diagnosed with acute HBV infections while 95.7% had chronic infections.Problematic alcohol use,injection drug use,and HIV or HCV co-infection were more common among individuals diagnosed with acute HBV compared to those with chronic infections and HBV negative individuals.In multivariable multinomial logistic regression models,we observed significant associations between acute or chronic HBV diagnosis and being male,age at HBV diagnosis or birth cohort,South and East Asian ethnicity,HCV or HIV infection,and injection drug use.The odds of acute HBV decreased with increasing age among people who inject drugs,while the opposite was true for chronic HBV.Persons with acute HBV were predominantly White(78%) while those with chronic HBV were mostly East Asian(60%).Relative to Whites,East Asians had 12 times greater odds of being diagnosed with chronic HBV infection.These odds increased with increasing socioeconomic deprivation.CONCLUSION Differences in the profiles of people diagnosed with acute and chronic HBV infection necessitate differentiated screening,prevention,care and treatment programs. | Mawuena Binka Zahid A Butt Stanley Wong Mei Chong Jane A Buxton Nuria Chapinal Amanda Yu Maria Alvarez Maryam Darvishian Jason Wong Gina McGowan Mikhail Torban Mark Gilbert Mark Tyndall Mel Krajden Naveed Z Janjua | 2018 | World Journal of Gastroenterology2018，24，11： | 3 |
| 2 | Malaria: current status of control, diagnosis, treatment, and a proposed agenda for research and development显示文摘 | Philippe J Guerin Piero Olliaro Francois Nosten Pierre Druilhe Ramanan Laxminarayan Fred Binka Wen L Kilama Nathan Ford Nicholas J White | 2002 | The Lancet Infectious Diseases2002，，9： | 2 |
| 3 | Immunogenicity of the pentavalent rotavirus vaccine in African infants显示文摘 | George E. Armah Robert F. Breiman Milagritos D. Tapia Michael J. Dallas Kathleen M. Neuzil Fred N. Binka Samba O. Sow Joel Ojwando Max Ciarlet A. Duncan Steele | 2012 | Vaccine2012，，： | 1 |
| 4 | Changing patterns of rotavirus genotypes in ghana: emergence of human rotavirus G9 as a major cause of diarrhea in children 显示文摘 | ARMAH GE STEELE AD BINKA FN | 2003 | J Clin Microbiol2003，41，6： | 1 |
| 5 | Characterisa- tion of norovirus strains in rural Ghanaian children with acute diarrhoea 显示文摘 | Armah GE Gallimore CI Binka FN | 2006 | J Med Virol2006，78，11： | 1 |
| 6 | Characterisation of norovirus strains in rural Ghanaian children with acute diarrhoea显示文摘 | Armah G E Gallimore C I Binka F N | 2006 | J Med Virol2006，78，11： | 1 |
| 7 | Changingpatterns of rotavirus genotypes in Ghana : emergence ofhuman rotavirus G9 as a major cause of diarrhea in chil-dren显示文摘 | Armah G E Steele A D Binka F N | 2003 | J Clin Microbiol2003，41，： | 1 |
| 8 | Changing patterns of ro- tavirus genotypes in ghana: emergence of human rotavirns G9 as a major cause of diarrhea in children 显示文摘 | Armah GE Steele AD Binka FN | 2003 | J Clin Microbiol2003，41，6： | 1 |
| 9 | The activity spectrum of Vif from multiple HIV-1 subtypes against APOBEC3G,APOBEC3F,and APO BEC3H显示文摘 | Binka M Ooms M Steward M et d | 2012 | J Virol2012，86，1： | 1 |
| 10 | Mortality in a seven-and-ahalf-year follow-up of a trial of insecticide-treated mosquito nets in Ghana显示文摘 | Binka FN Hodgson A Adjuik M | 2002 | Trans R Soc Trop Med Hyg2002，96，6： | 1 |
| 11 | Impact of permethrin im- pregnated bednets on child mortality in Kassena-Nankana dis- trict, Ghana: a randomized controlled trial显示文摘 | Binka FN Kubaje A Adjuik M | 1996 | Tropical Medi- cine and International Health1996，1，2： | 1 |
| 12 | Changing patterns of rota- virus genotypes Ghana: emergence of human rotavirus G9 as a major cause of diarrhea in children 显示文摘 | Armah GE Steele AD Binka FN | 2003 | J Clin Mircrobiol2003，41，6： | 1 |
| 13 | Monitoring future impact on malaria burden in sub-saharan Africa显示文摘 | de Savigny D Binka F | 2004 | Am J Trop Med Hyg2004，71，2： | 1 |
| 14 | Changing patternsof rotavirus genotypes in ghana:emergence of humanrotavirus G9 as a major cause of diarrhea in children显示文摘 | Armah GE Steele AD Binka FN | 2003 | JClin Microbiol2003，41，6： | 1 |
| 15 | Changing pattern of rotavirus genotypes Ghana: e- mergence of human rotavirus G9 as a major cause of di- arrhea in children 显示文摘 | Armah G E Steele AD Binka F N Esona M D As- mah R H Anto F Brown D Green J Cutts F Hall A | 2003 | J Clin Mircrobial2003，41，6： | 1 |
| 16 | Changing patterns of potavirns genotypes in Ghana: emergence of human rotavirus G9 as a major cause of diarrhea in children 显示文摘 | Armah GE Steele AD Binka FN | 2003 | J Clin Microbiol2003，41，6： | 1 |
| 17 | Malaria: current status of control, diagnosis, treatment, and a proposed agenda for research and development显示文摘 | Philippe J Guerin Piero Olliaro Francois Nosten Pierre Druilhe Ramanan Laxminarayan Fred Binka Wen L Kilama Nathan Ford Nicholas J White | 2002 | The Lancet Infectious Diseases2002，，9： | 1 |
| 18 | Toward a framework and indicators for monitoring Roll Back Malaria显示文摘 | Remme JH Binka F Nabarro D | 2001 | Am J Trop Med Hyg2001，64，12： | 1 |
| 19 | Faith-based organizations: sexual harassment and health in accra-tema metropolis显示文摘 | Norman 10 Aikins M Binka FN | 2013 | Sex Cult2013，17，1： | 1 |
| 20 | The activity spectrum of Vif from multiple HIV-1 subtypes against APOBEC3G,APOBEC3F,and APOBEC3H显示文摘 | BINKA M OOMS M STEWARD M | 2012 | J Virol2012，86，1： | 1 |
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