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| 1 | 经口腔达芬奇机器人甲状腺手术初步经验显示文摘目的探寻通过达芬奇机器人技术进行经口腔甲状腺切除术(transoral robotic thyroidectomy,TORT)是否可行并报道初步的经验教训。方法从2017年9月到12月,在北京和睦家医院进行了5例TORT。使用了3个完全口内切口连接达芬奇机器人手臂3个端口,回顾性分析手术结果。结果 5例均为女性患者(平均年龄30岁,平均肿瘤大小2. 0 cm),其中行单侧甲状腺腺叶切除4例、全切1例,3例行中央颈清扫。其中3例甲状腺乳头状癌(papillary thyroid carcinomas,PTC)、1例甲状腺滤泡癌、1例甲状腺良性腺瘤。平均手术时间为343 min。PTC患者中央淋巴结数目平均为8. 7枚。术后没有短暂性声带麻痹和低钙症状,3例患者术后有下唇感觉减退和感觉异常、1例因镜头接触发生皮瓣Ⅰ度烫伤。结论 TORT对于选择的甲状腺肿瘤患者初步尝试是可行的,是无瘢痕甲状腺手术选择之一。 | 张彬 韩宗辉 Bikash Rai | 2018 | 中华腔镜外科杂志(电子版)2018，11，4： | 21 |
| 2 | 经耳后达芬奇机器人甲状腺手术的初步经验显示文摘目的分析总结耳后入路达芬奇机器人甲状腺手术的经验,探讨此术式的可行性。方法回顾性分析2018年5月—12月,在北京和睦家医院采用无注气耳后入路达芬奇机器人手术的甲状腺癌患者5例,其中男1例,女4例,年龄18~37岁。其中1例为甲状腺癌甲状腺全切除术后颈部淋巴结复发。分析总结临床特点、治疗及预后。结果5例患者中行单侧甲状腺腺叶切除术1例,甲状腺全切除术3例,4例行颈侧清扫术,1例术中中转。5例病理均为甲状腺乳头状癌(papillary thyroid carcinoma,PTC),平均肿瘤大小1.3 cm,每侧平均手术时间约375 min。术后发生声带麻痹和低钙各1例次。结论对部分经选择的甲状腺肿瘤患者,初步尝试经耳后机器人手术是可行的,是颈外入路甲状腺手术的选择之一。 | 张彬 于灏 韩宗辉 Bikash Rai | 2020 | 中华耳鼻咽喉头颈外科杂志2020，55，3： | 13 |
| 3 | Twist基因对结肠癌细胞系侵袭转移能力影响的体外研究显示文摘目的:探讨Twist基因在SW480、HCT116和HT29结肠癌细胞系上皮-间质转化(EMT)中的作用,明确其对恶性肿瘤侵袭转移能力的影响。方法:利用重组质粒p Tracer-CMV/BSD-Twist和p Genesil1.2-Twist-shRNA转染SW480、HT29和HCT116;流式细胞术检测转染率;Real time-PCR和Western blot检测Twist、E-cadherin和Vimentin转录及蛋白表达水平;Transwell实验检测细胞的迁移和侵袭能力。结果:转染高表达Twist质粒后,各结肠癌细胞系中Twist和Vimentin表达水平显著升高(P<0.05),E-cadherin显著降低(P<0.05);转染低表达Twist质粒后,SW480和HT29中各指标均无显著变化(P>0.05),HCT116中Twist和Vimentin表达水平显著降低(P<0.05),E-cadherin无显著变化(P>0.05);Transwell实验表明抑制HCT116细胞系Twist表达后,其侵袭和迁移能力明显减弱(P<0.01)。结论:上调Twist表达可以促进EMT;抑制HCT116中Twist表达能减弱结肠癌细胞的侵袭和转移能力。 | 王多伟 Bikash Rai 王金淼 戚峰 刘彤 | 2017 | 天津医科大学学报2017，23，6： | 2 |
| 4 | 经口机器人手术治疗口咽癌的初步经验显示文摘目的探讨经口机器人手术(transoral robotic surgery,TORS)治疗口咽癌的肿瘤学及功能学效果,以及该方法的安全性。方法回顾性分析2017年6月1日至2020年12月31日北京和睦家医院行TORS治疗的口咽癌患者26例,其中男性22例,女性4例,年龄39~76岁。T1-2期患者占88.5%(23/26)。收集相关临床病理学及随访资料,记录患者拔除胃管及气管插管的时间,采用SPSS软件包进行生存分析,计算总生存率及无病生存率。结果26例口咽癌患者均接受TORS治疗,无中转开放手术,其中20例行同期颈淋巴清扫术。TORS手术时间为65~360 min,平均215 min。术中出血量5~600 ml,平均70 ml。术后4例患者(15.4%)行气管切开,其中3例术后1个月内拔除气管套管,1例至随访结束未能拔除。12例患者(46.2%)行胃管置入,其中11例术后1个月内拔除胃管,1例患者术后13 d因口咽部出血死亡,死亡时胃管尚未拔除。术后1例患者(3.8%)切缘阳性,余患者切缘阴性。16例患者(61.5%)行术后放疗,其中11例患者(42.3%)进行以铂类为主的同步化疗。中位随访时间21.5个月(0.4~45.0个月)。3年总生存率为83.0%,3年无病生存率为75.8%。结论选择合适的口咽癌患者,TORS可取得良好的肿瘤学及功能学效果,手术并发症较少,治疗安全可行。 | 张亚冰 Bikash Rai 智迎辉 张彬 | 2022 | 中华耳鼻咽喉头颈外科杂志2022，57，5： | 2 |
| 5 | Induction with NCB-02 (curcumin) enema for mild-to-moderate distal ulcerative colitis — A randomized, placebo-controlled, pilot study显示文摘 | Vikas Singla Venigalla Pratap Mouli Sushil Kumar Garg Tarun Rai Bikash Narayan Choudhury Prashant Verma Rachana Deb Veena Tiwari Sarika Rohatgi Rajan Dhingra Saurabh Kedia Piyush Kumar Sharma Govind Makharia Vineet Ahuja | 2014 | Journal of Crohn’s and Colitis2014，，3： | 1 |
| 6 | Three-port transoral robotic thyroidectomy without axillary incision:A preliminary report of 20 cases in China显示文摘Objective:Transoral scarless thyroid surgery has proven to be a popular alternative to traditional approaches.Transoral robotic thyroidectomy(TORT)has been reported using ports on the lower lip and axilla.Avoiding axillary incision can further reduce scars on the armpit.Here,we present our preliminary data from the initial 20 consecutive patients to explore the feasibility of three-port TORT without axillary incision.Methods:From September 2017 to June 2019,we performed TORT at Beijing United Family Hospital using three intraoral ports without axillary incision via the da Vinci Si system with three robotic arms.The outcomes of the procedure were retrospectively reviewed.Results:Among 20 patients(mean age 30±7 years;mean tumor size 1.64±0.96 cm),16 patients underwent unilateral thyroid lobectomy and four had total thyroidectomy with or without central neck dissection.Eighteen patients had papillary thyroid carcinomas(PTC),one had a follicular thyroid carcinoma,and one had a thyroid adenoma.The mean surgical time was 221±68 min.The mean number of retrieved central lymph nodes in the PTC patients was 5.6±5.There was no permanent vocal cord palsy or hypocalcemia postoperatively.One patient had transient vocal cord palsy,which resolved within 1 week.Paresthesia of the lower lip and the chin was observed in nine patients,and one patient had a first-degree burn of the skin flap due to the lens.Conclusion:Three-port TORT without axillary incision is feasible for selected patients and would be a potential alternative for remote-access thyroid surgery to avoid leaving scars on the neck or the armpit. | Bin Zhang Bikash Rai Kuang-yu Fei Zong-hui Han Michelle Savu | 2023 | World Journal of Otorhinolaryngology-Head and Neck Surgery2023，9，2： | 0 |
| 7 | A report on TypeⅡX-ray bursts from SMC X-1显示文摘We study RXTE PCA data for the high mass X-ray binary source SMC X-1 between 2003–10 and 2003–12 when the source was in its high states.The source is found to be frequently bursting which can be seen as flares in lightcurves that occur at a rate of one every 800 s, with an average of 4–5 Type Ⅱ X-ray bursts per hour.We note that typically a burst was short, lasting for a few tens of seconds in addition to a few long bursts spanning more than a hundred seconds that were also observed.The flares apparently occupied 2.5% of the total observing time of 225.5 ks.We note a total of 272 flares with mean FWHM of the flare ~21 s.The rms variability and aperiodic variability are independent of flares.As observed, the pulse profiles of the lightcurves do not change their shape, implying that there is no change in the geometry of an accretion disk due to a burst.The hardness ratio and rms variability of lightcurves exhibit no correlation with the flares.The flare fraction shows a positive correlation with the peak-to-peak ratio of the primary and secondary peaks of the pulse profile.The observed hardening or softening of the spectrum cannot be correlated with the flaring rate but may be due to the interstellar absorption of X-rays as evident from the change in hydrogen column density(n_H).It is found that the luminosity of the source increases with the flaring rate.Considering that the viscous timescale is equal to the mean recurrence time of flares, we fixed the viscosity parameter α~ 0.16. | Binay Rai Pragati Pradhan Bikash Chandra Paul | 2018 | Research in Astronomy and Astrophysics2018，18，12： | 0 |
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