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| 1 | Islet cell dysfunction in patients with chronic pancreatitis显示文摘Chronic pancreatitis(CP)is characterized by progressive inflammation and fibrosis of the pancreas that eventually leads to pancreatic exocrine and endocrine insufficiency.Diabetes in the background of CP is very difficult to manage due to high glycemic variability and concomitant malabsorption.Progressive beta cell loss leading to insulin deficiency is the cardinal mechanism underlying diabetes development in CP.Alpha cell dysfunction leading to deranged glucagon secretion has been described in different studies using a variety of stimuli in CP.However,the emerging evidence is varied probably because of dependence on the study procedure,the study population as well as on the stage of the disease.The mechanism behind islet cell dysfunction in CP is multifactorial.The intra-islet alpha and beta cell regulation of each other is often lost.Moreover,secretion of the incretin hormones such as glucagon like peptide-1 and glucose-dependent insulinotropic polypeptide is dysregulated.This significantly contributes to islet cell disturbances.Persistent and progressive inflammation with changes in the function of other cells such as islet delta cells and pancreatic polypeptide cells are also implicated in CP.In addition,the different surgical procedures performed in patients with CP and antihyperglycemic drugs used to treat diabetes associated with CP also affect islet cell function.Hence,different factors such as chronic inflammation,dysregulated incretin axis,surgical interventions and anti-diabetic drugs all affect islet cell function in patients with CP.Newer therapies targeting alpha cell function and beta cell regeneration would be useful in the management of pancreatic diabetes in the near future. | Ayan Roy Jayaprakash Sahoo Sadishkumar Kamalanathan Dukhabandhu Naik Pazhanivel Mohan Biju Pottakkat | 2020 | World Journal of Diabetes2020，11，7： | 5 |
| 2 | 虹鳟鱼营养与摄食研究进展显示文摘虹鳟鱼(Oncorhynchus mykiss)是世界上广泛养殖的冷水性鱼。在集约化养殖中,科学的饲喂对虹鳟鱼生长、发育和繁殖非常重要。此外,饲料的配制和生产,是虹鳟鱼养殖过程中的主要成本,为了提高饲料以及饲料中营养物质的利用率,须更好地了解鱼类摄食、消化和新陈代谢之间的生理机制。 | 窦玉龙 吴立新 Biju Sam Kamalam J | 2021 | 中国水产2021，，4： | 3 |
| 3 | Pathological abnormalities in splenic vasculature in non-cirrhotic portal hypertension:Its relevance in the management of portal hypertension显示文摘BACKGROUND Portal hypertension(PH)is associated with changes in vascular structure and function of the portosplenomesenteric system(PSMS).This is referred to as portal hypertensive vasculopathy.Pathological abnormalities of PSMS has been described in the literature for cirrhotic patients.Raised portal pressure and hyperdynamic circulation are thought to be the underlying cause of this vasculopathy.In view of this,it is expected that pathological changes in splenic and portal vein similar to those reported in cirrhotic patients with PH may also be present in patients with non-cirrhotic PH(NCPH).AIM To investigate pathological abnormalities of splenic vein in patients with NCPH,and suggest its possible implications in the management of PH.METHODS A prospective observational study was performed on 116 patients with NCPH[Extrahepatic portal vein obstruction(EHPVO):53 and non-cirrhotic portal fibrosis(NCPF):63]who underwent proximal splenorenal shunt(PSRS),interposition shunt or splenectomy with devascularization in JIPMER,Pondicherry,India,a tertiary level referral center,between 2011-2016.All patients were evaluated by Doppler study of PSMS,computed tomography portovenogram and upper gastrointestinal endoscopy.An acoustic resonance forced impulse(ARFI)scan and abdomen ultrasound were done for all cases to exclude cirrhosis.Intraoperative and histopathological assessment of the harvested splenic vein was performed in all.The study group was divided into delayed and early presentation based on the median duration of symptoms(i.e.108 mo).RESULTS The study group comprising of 116 patients[77(66%)females and 39(34%)males]with NCPH had a median age of 22 years.Median duration of symptoms was 108 mo.The most common presentation in both EHPVO and NCPF patients was upper gastrointestinal bleeding(hematemesis and melena).The ARFI scan revealed a median score of 1.2(1.0-1.8)m/s for EHPVO and 1.5(0.9-2.8)m/s for NCPF.PSRS was performed in 84 patients(two of whom underwent interposition PSRS using a 10 mm Dacron graft);splenoadrenal shunt in 9;interposition mesocaval shunt in 5;interposition 1st jejunal to caval shunt in 1 patient and devascularization with splenectomy in 17 patients.Median presplenectomy portal pressure was 25(range:15-51)mm Hg.In 77%cases,the splenic vein was abnormal upon intraoperative assessment.Under macroscopic examination,wall thickening was observed in 108(93%),venous thrombosis in 32(28%)and vein wall calcification in 27(23%)cases.Upon examination under a surgical magnification loupe,21(18%)patients had intimal defects in the splenic vein.Histopathological examination of veins was abnormal in all cases.Medial hypertrophy was noted in nearly all patients(107/116),while intimal fibrosis was seen in 30%.Ninety one percent of patients with intimal fibrosis also had venous thrombosis.Vein wall calcification was found in 22%,all of whom had intimal fibrosis and venous thrombosis.The proportion of patients with pathological abnormalities in the splenic vein were significantly greater in the delayed presentation group as compared to the early presentation group.CONCLUSION Pathological changes in the splenic vein similar to those in cirrhotic patients with PH are noted in NCPH.We recommend that PH in NCPH be treated as systemic and pulmonary hypertension equivalent in the gastrointestinal tract,and that early aggressive therapy be initiated to reduce portal pressure and hemodynamic stress to avoid potential lethal effects. | Shahana Gupta Biju Pottakkat Surendra Kumar Verma Raja Kalayarasan Sandip Chandrasekar A Ajith Ananthakrishna Pillai | 2020 | World Journal of Gastrointestinal Surgery2020，12，1： | 3 |
| 4 | Risk factors of thrombosis in abdominal veins显示文摘AIM: To estimate the prevalence of inherited and acquired thrombophilic risk factors in patients with abdominal venous thrombosis and to compare the risk factor profiles between Budd-Chiari syndromes (BCS) and splanchnic vein thrombosis (SVT). METHODS: In this retrospective study, 36 patients with abdominal venous thrombosis were studied. The patients were divided into Budd-Chiari group (hepatic vein, IVC thrombosis) and splanchnic venous thrombosis group (portal, splenic, superior mesenteric veins) based on the veins involved. Hereditary and acquired thrombophilic risk factors were evaluated in all patients. RESULTS: Twenty patients had SVT, 14 had BCS, and 2 had mixed venous thrombosis. Ten patients (28%) had hereditary and 10 patients (28%) acquired thrombophilic risk factors. The acquired risk factors were significantly more common in the SVT group (SVT vs BCS: 45% vs 7%, χ2 = 5.7, P = 0.02) while hereditary risk factors did not show significant differences between the two groups (SVT vs BCS: 25% vs 36%, χ2 = 0.46, P = 0.7). Multiple risk factors were present in one (7%) patient with BCS and in 3 patients (15%) with SVT. No risk factors were identified in 57% of patients with BCS and in 45% of patients with SVT. CONCLUSION: Hereditary and acquired risk factors play an important role in the etiopathogenesis of abdominal venous thrombosis. Acquired risk factorsare significantly more common in SVT patients while hereditary factors are similar in both groups. | Amit Kumar Dutta Ashok Chacko Biju George Joseph Anjilivelil Joseph Sukesh Chandran Nair Vikram Mathews | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 5 | Structural and luminescence enhancement properties of Eu^(3+)/Ag nanocrystallites doped SiO_2-TiO_2 matrices显示文摘We reported here the structural and optical characterisation of silver nanocrystallites/Eu3+ :SiO2-TiO2 matrices synthesised through sol-gel route. Structural characterisations were done by using energy dispersive spectroscopy (EDX), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), atomic force microscope (AFM) and transmission electron microscopy (TEM) measurements and optical characterisations were performed by absorption and emission spectroscopy. The TEM and XRD measurements confirmed the presence of nanocrystals. A broad absorption band was observed due to surface plasmon resonance of silver nanocrystals. The effect of silver nanocrystals on the emission spectrum of Eu3+ doped SiO2-TiO2 matrices was discussed. An attempt was made to explain this fluorescence enhancement by invoking phenomena such as energy transfer, asymmetry ratio, surface plasmon, surface roughness, crystallinity and grain boundary. Our analysis, based on the experimental results, suggested that all the phenomena except crystallinity and grain boundary had favourable effects on fluorescence enhancement. We also estimated the relevant parameters associated with the phenomena that affected the fluorescence emission from the Eu3+ ions in the matrix. It was seen that the theoretical estimate of fluorescence enhancement agreed well with the experimental estimate. | Arun Kumar K V Revathy K P Prathibha Vasudevan Sunil Thomas Biju P R Unnikrishnan N V | 2013 | Journal of Rare Earths2013，31，5： | 2 |
| 6 | Mesenchymal Stem Cells as Therapeutics显示文摘 | Biju Parekkadan Jack M. Milwid | 2010 | Annual Review of Biomedical Engineering2010，，： | 2 |
| 7 | Anatase to rurile transformation in sol-gel titania by modification of precursor 显示文摘 | Suresh C Biju V Mukundan P | 1998 | Polyhedron1998，17，18： | 1 |
| 8 | Shape selective synthesis of long-chain linear alkyl benzene (LAB) with AlMCM-41/Beta zeolite composite catalyst显示文摘 | Bordoloi Ankur Devassy Biju M Niphadkar P S | 2006 | Journal of Molecular Catalysis A:Chemical2006，253，23： | 1 |
| 9 | Association of growth differentiation factor 15 (GDF15) polymorphisms with serum GDF15 and ferritin levels in β-thalassemia显示文摘 | Rekha Athiyarath Biju George Vikram Mathews Alok Srivastava Eunice S. Edison | 2014 | Annals of Hematology2014，，12： | 1 |
| 10 | Estimation of lattice strain in nanocrystalline silver from X-ray diffraction line broadening 显示文摘 | Biju V Sugathan Necna Vrinda V | 2008 | J Mater Sci2008，43，： | 1 |
| 11 | Hypoxia inducible factor l alpha regulates T cell receptor signal transduction显示文摘 | Neumann AK Yang J Biju MP et a1 | 2005 | Proc Natl Acad Sci USA2005，102，17： | 1 |
| 12 | An overview of electro-ehemiluminescent (ECL) technology in laboratory investigations显示文摘 | Mathew B C Biju R S Thapalia N | 2005 | Kathmandu Univ Med J2005，3，1： | 1 |
| 13 | DC conductivity of consolidated nanoparticles of NiO 显示文摘 | Biju V Abdul Khadar M | 2001 | Materials Research Bulletin2001，，36： | 1 |
| 14 | Spectroscopic parameters of Nd3+ ion in phosphate glass显示文摘 | Kumar G A Biju P R Venugopal C | 1997 | Journal of Non-Crystal Solid1997，221，： | 1 |
| 15 | Power of 22 microsatellite markers in flurescent multiplexes for parentage testing in goats显示文摘 | Biju Duval M P Ertugrul O | 1999 | Animal Genetics1999，30，： | 1 |
| 16 | Hypoxic induction of CTGF is directly mediated by HIF - 1 显示文摘 | Higgins DF Biju MP Akai Y | 2004 | Am J Physiol Renal Physiol2004，287，： | 1 |
| 17 | Effect of polyethylene glycol additive in sol on the humidity sensing properties of a TiO2 thin film显示文摘 | Biju K P Jain M K | 2007 | Measurement Science and Technology2007，188，： | 1 |
| 18 | Bioconjugated quantum dots for cancer research: Present status, prospects and remaining issues 显示文摘 | Biju V Mundayoor S Omkumar R V | 2010 | Biotechnol Adv2010，28，2： | 1 |
| 19 | Hypoxic induction of Ctgf is directly mediated by Hif-1显示文摘 | Higgins DF Biju MP Akai Y | | 0，，： | 1 |
| 20 | Improved superconducting properties by La addition in(Bi,Pb)-2212 bluk superconductor显示文摘 | Biju A Vinod K Aloysius R P | 2007 | Journal of Alloys Compounds2007，431，： | 1 |
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