|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Low-dose tacrolimus ameliorates liver inflammation and fibrosis in steroid refractory autoimmune hepatitis显示文摘AIM: To determine the eff icacy of tacrolimus on clinical status, histopathological status and biochemical markers in patients with steroid refractory autoimmune hepatitis (AIH). METHODS: Retrospectively, clinical parameters, biochemistry and histology were obtained from patient records. RESULTS: Nine patients [8 females/1 male, median age 32 (range 16-64) years] were identified to have received tacrolimus for a median duration of 18 (12-37) mo. Before initiation of tacrolimus treatment the patients were maintained on a prednisolone dose of 20 mg daily (range 20-80 mg/d), which was tapered to 7.5 (5-12.5) mg/d (P = 0.004). Alanine aminotransferase and immunoglobulin-G concentrations decreased from 154 (100-475) to 47(22-61) U/L (P = 0.007), and from 16 (10-30.2) to 14.5 (8.4-20) g/L (P = 0.032), respectively. All patients showed improvement of the liver inflammatory activity, as determined by the Ishak score (P = 0.016), while the degree of f ibrosis tended to decrease (P = 0.049). CONCLUSION: The use of low dose tacrolimus can lead to biochemical and histologic improvement of inflammation with no progression of the stage of f ibrosis in patients with steroid refractory AIH. Low dose tacrolimus therapy also allows substantial reduction of prednisone dose. | Fin Stolze Larsen Ben Vainer Martin Eefsen Peter Nissen Bjerring Bent Adel Hansen | 2007 | World Journal of Gastroenterology2007，13，23： | 15 |
| 2 | Oxygen radical formation does not have an impact in the treatment of severe acute experimental pancreatitis using free cellular hemoglobin显示文摘瞄准:Microcirculatory 机能障碍和免费的氧激进分子是在严重尖锐胰腺炎的致病的重要因素。另外的氧交货可能每氧化提高类脂化合物,但是可以也改进胰腺的微循环。这研究在严重尖锐胰腺炎的一个啮齿类动物模型在氧激进分子和微循环的形成上估计免费细胞的牛的血红素的效果。方法:在尖锐胰腺炎 Wistar 老鼠的正式就职以后的十五分钟收到了任何一个 0.8 mL 牛的血红素(HBOC-200 ) , hydroxyethyl 淀粉(HES ) 或保证血量正常替换的生理盐水的 2.4 mL。在检查的 6 h 以后,胰每氧化产品 malondialdehyde (MDA ) 为类脂化合物的间接测量被切除并且很快处理了并且在胰腺的织物减少了谷胱甘肽(GSH ) 。结果:HBOC-200 的单个申请改进了胰腺的微循环并且显著地减少了组织病理学说的织物损坏。MDA 的织物集中没在这些组之间不同。另外,在 GSH 层次的差别都没被检测。结论:不过 HBOC-200 和 HES 的单个申请改进胰腺的微循环,在类脂化合物的没有差别每氧化,产品被检测。另外的氧供应(HBOC-200 ) 的有益的效果不每氧化导致提高的类脂化合物。 | Helge Kleinhans Oliver Mann Paulus G Schurr Jussuf T Kaifi Bente Hansen Jakob R Izbicki Tim Strate | 2006 | World Journal of Gastroenterology2006，12，18： | 6 |
| 3 | Effect of Prometheus liver assist system on systemic hemodynamics in patients with cirrhosis: A randomized controlled study显示文摘AIM: To evaluate treatment safety and hemodynamic changes during a single 6-h treatment with the Prometheus? liver assist system in a randomized, controlled study. METHODS: Twenty-four patients were randomized to either the study group or to one of two control groups: Fractionated Plasma Separation Adsorption and Dialysis, Prometheus? system (Study group; n = 8); Molecular Adsorbent Recirculation System (MARS)? (Control group 1, n = 8); or hemodialysis (Control group 2; n = 8). All patients included in the study had decompensated cirrhosis at the time of the inclusion into the study. Circulatory changes were monitored with a Swan-Ganz catheter and bilirubin and creatinine were monitored as measures of protein-bound and water-soluble toxins. RESULTS: Systemic hemodynamics did not differ between treatment and control groups apart from an increase in arterial pressure in the MARS group (P = 0.008). No adverse effects were observed in any of the groups. Creatinine levels significantly decreased in the MARS group (P = 0.03) and hemodialysis group (P = 0.04). Platelet count deceased in the Prometheus group (P = 0.04).CONCLUSION: Extra-corporal liver support with Prometheus is proven to be safe in patients with end- stage liver disease but does not exert the beneficial effects on arterial pressure as seen in the MARS group. | Thomas Dethloff Flemming Tofteng Hans-Jorgen Frederiksen Michael Hojskov Bent Adel Hansen Fin Stolze Larsen | 2008 | World Journal of Gastroenterology2008，14，13： | 4 |
| 4 | s7 Sr/S6 Sr ratio : a natural tracer to monitor groundwater flow paths during artificial re- charge in the Bangkok area, Thailand 显示文摘 | Janina S Klaus Bent T Hansen Somkid Buapeng | 2007 | Hydrogeology Journal2007，15，： | 1 |
| 5 | Efficacy of citalopram in the prevention of recurrent depression in elderly patients: placebo - controlled study of maintenance therapy 显示文摘 | Klysner R Bent - Hansen J Hansen HL | 2002 | Br J Psychiatry2002，181，： | 1 |
| 6 | Assessment of the importance of sorption for steroid estrogens removal during activated sludge treatment显示文摘 | Henrik Rasmus Andersen Martin Hansen Jesper Kj?lholt Frank Stuer-Lauridsen Thomas Ternes Bent Halling-S?rensen | 2005 | Chemosphere2005，，1： | 1 |
| 7 | The Effect of cage environment and ad libitum fccding on the circadian rhythm behaviour and feed intake of farm mink显示文摘 | Steffen W Hansen Bente Krogh Hansen Peer Berg | | 0，，02： | 1 |
| 8 | Fatigue and physical function after orthotopic liver transplantation显示文摘 | Mette Aadahl Bent Adel Hansen Preben Kirkegaard Mogens Groenvold | 2002 | Liver Transplantation2002，，3： | 1 |
| 9 | 87Sr/86Sr ratio:a natural tracer to monitor groundwater flow paths during artificial recharge in the Bangkok area,Thailand显示文摘 | Janina S Klaus Bent T Hansen Somkid Buapeng | 2007 | Hydrogeology Journal2007，15，： | 1 |
| 10 | The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema显示文摘 | Peter Nissen Bjerring Martin Eefsen Bent Adel Hansen Fin Stolze Larsen | 2009 | Metabolic Brain Disease2009，，1： | 1 |
| 11 | Over-expression of Follistatin-like 3 attenuates fat accumulation and improves insulin sensitivity in mice显示文摘 | Claus Brandt Rasmus Hvass Hansen Jakob Bondo Hansen Caroline Holkmann Olsen Pia Galle Thomas Mandrup-Poulsen Julie Gehl Bente Klarlund Pedersen Pernille Hojman | 2014 | Metabolism2014，，： | 1 |
| 12 | Cerebral microdialysis in patients with fulminant hepatic failure显示文摘 | Flemming Tofteng Linda Jorgensen Bent Adel Hansen Peter Ott Jens Kondrup Fin Stolze Larsen | 2002 | Hepatology2002，，6： | 1 |
| 13 | Ecological modernization and institutional transformations in the Danish textile industry显示文摘 | Bent Sφndergard Ole Erik Hansen Jesper Holm | 2004 | Journal of Cleaner Production2004，12，4： | 1 |
| 14 | Vaccination with heat - killed Listeria as adjuvant reverses established allergen- induced airway hyperreactivity and inflammation: role of CD8^+ T cells and IL- 18显示文摘 | Hansen G Yeung VP BenT G | 2000 | J Immunol2000，164，1： | 1 |
| 15 | Efficacy of citalopram in the prevention of recurrent depression in elderly patients: placebo - controlled study of maintenance therapy 显示文摘 | Bent - Hansen J Hansen HL | 2002 | Bri J Psychiaty2002，181，： | 1 |
| 16 | Immunoreactive material resembling vertebrate neuropeptides in the corpus cardiacum and corpus allatum of the insect Leucophaea moderae显示文摘 | Dr. Bente Langvad Hansen Georg N?rgaard Hansen Berta Scharrer | 1982 | Cell and Tissue Research1982，，2： | 1 |
| 17 | Regional Cerebral Blood Flow Autoregulation in Patients With Fulminant Hepatic Failure显示文摘 | Fin Stolze Larsen Gitte Strauss Kirsten M?ller Bent Adel Hansen | 2000 | Liver Transplantation2000，，6： | 1 |
| 18 | Cerebral perfusion, cardiac output, and arterial pressure in patients with fulminant hepatic failure显示文摘 | Fin Stolze Larsen Gitte Strauss Gitte Moos Knudsen Tina Maria Herzog Bent Adel Hansen Niels H. Secher | 2000 | Critical Care Medicine2000，，4： | 1 |
| 19 | Hyperventilation restores cerebral blood flow autoregulation in patients with acute liver failure显示文摘 | Gitte Strauss Bent Adel Hansen Gitte Moos Knudsen Fin Stolze Larsen | 1998 | Journal of Hepatology1998，，2： | 1 |
| 20 | Dissociated cerebral vasoparalysis in acute liver failure显示文摘 | Fin Stolze Larsen Bent Adel Hansen Frank Pott Ellen Ejlersen Niels H. Secher Olaf B. Paulson Gitte Moos Knudsen | 1996 | Journal of Hepatology1996，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员