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| 1 | 通络清脑注射液对脑缺血再灌注损伤大鼠脑微透析液中两种氨基酸水平的影响显示文摘目的:观察清热解毒活血中药有效组分配伍通络清脑注射液对脑缺血再灌注损伤大鼠脑微透析液中2种氨基酸类神经递质谷氨酸(Glu)和γ-氨基丁酸(gamma-aminobutyric acid,GABA)水平的影响。方法:24只SD大鼠随机分为大脑中动脉阻塞/再灌注(MCAO/RP)模型组,尼莫地平组(0.4 mg·kg-1),通络清脑注射液低剂量组(48 mg·kg-1)及高剂量组(95mg·kg-1),每组6只。采用微透析技术对大鼠纹状体脑组织进行连续取样,流速1μL·min-1,每30 min采集1个样品。收集至第3个样品时,采用线栓法制备MCAO/RP模型,90 min后拔出线栓,实现再灌注,同时经大鼠尾静脉给予各组药物,继续收集微透析液至再灌注后180 min。微透析液样品经柱前衍生化后,经高效液相色谱-电化学(HPLC-ECD)检测Glu和GABA的水平。分别以造模时间点Glu及GABA含量为基础值计算释放率百分比。结果:建立MCAO模型后,各组Glu,GABA释放量均急剧上升,造模后120 min,通络清脑注射液高剂量组Glu释放量(327.29±127.31)%与模型组(1 041.08±190.57)%相比明显下降(P<0.05),造模后120,150 min,通络清脑注射液高剂量组GABA释放量(11 843.99±3 952.45)%,(4 785.80±3 051.98)%与模型组(35 204.61±6 919.45)%,(27 694.76±18 393.61)%相比明显下降(P<0.05)。随后各组Glu,GABA释放量均呈逐渐下降趋势。结论:抑制氨基酸的过量释放是通络清脑注射液抗脑缺血/再灌注损伤的可能机制之一。 | 姚明江 张鹏 宋文婷 徐立 Alan Bensoussan Dennis Chang 刘建勋 | 2014 | 中国实验方剂学杂志2014，20，12： | 8 |
| 2 | Cupping therapy for acute and chronic pain management:a systematic review of randomized clinical trials显示文摘Objective:Cupping as a traditional therapy is used to treat a myriad of health conditions,including pain.This systematic review assessed the effectiveness and safety of cupping for different types of pain.Methods:Thirteen databases and four trial registries were searched for randomized clinical trials.Meta-analysis of data was conducted if there was non-significant clinical and statistical heterogeneity(measured by I2 test)among trials.Results:Sixteen trials with 921 participants were eligible and included.Six trials were assessed as low risk of bias,another six trials were of unclear risk of bias,and the remaining four trials were of high risk of bias.Pain was related to three acute and seven chronic diseases.Metaanalysis showed a beneficial effect of cupping compared to wait-list control(visual analogue scale(VAS),MD1.85 cm,95%CI2.66 to1.04)and heat therapy(numerical rating scale,MD2.05 cm,95%CI2.93 to1.17).Cupping combined with acupuncture was superior to acupuncture alone on post-treatment pain intensity(VAS,MD1.18 cm,95%CI1.68 to0.68),however,no difference was found between this comparison based on changes in pain intensity(difference of VAS,MD 0.16 cm,95%CI0.54 to 0.87).Results from other single studies showed significant benefit of cupping compared with conventional drugs or usual care.Hematoma and pain at the treated site,increasing local pain or tingling were reported as mild adverse effects of cupping.Conclusion:This review suggests a potential positive short-term effect of cupping therapy on reducing pain intensity compared with no treatment,heat therapy,usual care,or conventional drugs. | Huijuan Cao Xun Li Xue Yan Nissi S.Wang Alan Bensoussan Jianping Liu | 2014 | Journal of Traditional Chinese Medical Sciences2014，1，1： | 3 |
| 3 | 浅析澳大利亚与中国高校中医学教育的差异显示文摘澳大利亚较早开始中医学教育,是目前为数不多的在综合高校里设置中医学位课程的西方国家之一。本文从专业背景、文化差异、中医英语、师资团队、学生群体、授课形式和临床带教等多个方面对澳大利亚与中国高校中医学教育的差异进行简要分析,以期为中医学的国际传播和教育提供借鉴。 | 张勇 王珊珊 张丹英 张立平 Alan Bensoussan ZHU Xiao-shu | 2018 | 中国中西医结合杂志2018，38，10： | 2 |
| 4 | Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis显示文摘 | Benjamin MP Tang Guy D Eslick Caryl Nowson Caroline Smith Alan Bensoussan | 2007 | The Lancet2007，，9588： | 2 |
| 5 | Optimum inventory and product quality control with deterministic and stochastic deterioration-An application of distributed parameters control systems显示文摘 | Bensoussan A Nissen G Tapiero C | 1975 | IEEE Trans on Automatic Control1975，20，3： | 1 |
| 6 | Basis of predictive mycology显示文摘 | Dantigny P Guilmart A Bensoussan M | 2005 | International Jouranl of Food Microbiology2005，100，： | 1 |
| 7 | Optimal consumption and portfolio decisions with partially observed real prices显示文摘 | Bensoussan A Keppo J Sethi S P | 2009 | Mathematical Finance2009，19，2： | 1 |
| 8 | Evaluation of pa- tients with gait abnormalities in physical and rehabilitation medicine settings 显示文摘 | Bensoussan L Viton JM Barotsis N | 2008 | J Rehabil Med2008，40，7： | 1 |
| 9 | Treat- ment of irritable bowel syndrome with Chinese herbal medicine -a randomized controlled trial 显示文摘 | Bensoussan A Talley N J Hing M | 1998 | JAMA1998，280，18： | 1 |
| 10 | Stochastic games for N players 显示文摘 | Bensoussan A Frehse J | 2000 | Journal of Optimization Theory and Applications2000，105，3： | 1 |
| 11 | Kinematic and ki- netic asymmetries in hemiplegic patients' gait initiation pat- terns显示文摘 | Bensoussan L Mesure S Viton JM | 2006 | J Rehabil Med2006，38，5： | 1 |
| 12 | Modelling the effect of ethanol on growth rate of food spoilage moulds显示文摘 | Philippe Dantigny Audrey Guilmart Florentina Radoi Maurice Bensoussan Marcel Zwietering | 2004 | International Journal of Food Microbiology2004，，3： | 1 |
| 13 | A class of non-zero-sum stochastic differential investment and reinsurance games显示文摘 | Bensoussan A Siu C C Yam S C P Yang H | 2014 | Automatica2014，50，8： | 1 |
| 14 | Pyloric atresia显示文摘 | Ducharme JC Bensoussan AL | 1975 | J Pediatr Surg1975，10，1： | 1 |
| 15 | Strategic and Competitive Analy-sis显示文摘 | Fleisher C S Bensoussan B E | 2003 | Englewood Cliffs: Prentice - Hall2003，，： | 1 |
| 16 | Optimal con- sumption and portfolio decisions with partially observed true prices 显示文摘 | BENSOUSSAN A KEPPO J SETHI S P | 2009 | Mathematical Finance2009，19，2： | 1 |
| 17 | Optimal consumption and portfolio decisions with partially observed real prices显示文摘 | Bensoussan A Keppo J Sethi S P | 2009 | Mathematical Finance2009，19，2： | 1 |
| 18 | Chinese herbal medicines for people with impaired glucose tolerance or impaired fasting blood glucose显示文摘 | Grant S J Bensoussan A Chang D | 2009 | Cochrane Database Syst Rev2009，7，4： | 1 |
| 19 | Controle impulsionnel et inequations quasi - variationnelles statiormaires 显示文摘 | Bensoussan A Lions J L | 1973 | C R Ac Sci Paris1973，276，： | 1 |
| 20 | Nouvelle formulation de problems decontrole impulsionnel et applications 显示文摘 | Bensoussan A Lions J L | 1973 | C R Ac Sci Paris1973，276，： | 1 |
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