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| 1 | siRNA, miRNA and HIV: promises and challenges显示文摘Small interfering RNA (siRNA) and microRNA (miRNA) are small RNAs of 18-25 nucleotides (nt) in length that play important roles in regulating gene expression. They are incorporated into an RNA-induced silencing complex (RISC) and serve as guides for silencing their corresponding target mRNAs based on complementary base-pairing. The promise of gene silencing has led many researchers to consider siRNA as an anti-viral tool. However, in long-term settings, many viruses appear to escape from this therapeutical strategy. An example of this may be seen in the case of human immunodeficiency virus type-1 (HIV-1) which is able to evade RNA silencing by either mutating the siRNA- targeted sequence or by encoding for a partial suppressor of RNAi (RNA interference). On the other hand, because miRNA targeting does not require absolute complementarity of base-pairing, mutational escape by viruses from miRNA- specified silencing may be more difficult to achieve. In this review, we discuss stratagems used by various viruses to avoid the cells’ antiviral si/mi-RNA defenses and notions of how viruses might control and regulate host cell genes by encoding viral miRNAs (vmiRNAs). | Man Lung YEUNG Yamina BENNASSER Shu Yun LE Kuan Teh JEANG | 2005 | Cell Research2005，15，11： | 7 |
| 2 | miRNAs in the biology of cancers and viral infections显示文摘 | Yeung M L Bennasser Y Jeang K T | 2007 | Curr Med Chem2007，14，： | 1 |
| 3 | Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing显示文摘 | BENNASSER Y LE S Y BENKIRANE M | 2005 | Immunity2005，22，5： | 1 |
| 4 | HIV-1 TAR RNA subverts RNA interference in transfected cells through sequestration of TAR RNA-binding protein,TRBP显示文摘 | Bennasser Y Yeung M L Jeang K T | 2006 | J Biol Chem2006，281，27： | 1 |
| 5 | Suppression of microRNA-silencing pathway by HIV-1 during virus replicatiON显示文摘 | Triboulet R Mari B Lin YL Chable-Bessia C Bennasser Y Lebrigand K Cardinaud R.Maurin T Barbry P Baillat V | | 0，，5818： | 1 |
| 6 | Changes in microRNA expression profiles in HIV-1-transfected human cells显示文摘 | Yeung ML Bennasser Y Myers T G | 2005 | Retrovirolo-gy2005，2，： | 1 |
| 7 | Evidence that HIV1 encodes an siRNA and a suppressor of RNA silencing显示文摘 | Bennasser Y Le S Y Benkirane M | 2005 | Immunity2005，22，3： | 1 |
| 8 | HIV-1 Tat protein induces IL-10 production by an alternative TNF-alpha-independent pathway in monocytes : roleof PKC-delta and p38 MAP kinase显示文摘 | Leghmari K Bennasser Y Tkaczuk J | 2008 | Cell Immunol2008，253，12： | 1 |
| 9 | HIV-1 encoded candidate micro-RNAs and their cellular targets显示文摘 | Bennasser Y Le SY Yeung ML | 2004 | Retrovirology2004，1，1： | 1 |
| 10 | HIV-1 encoded candidate micro-RNAs and their cellular targets 显示文摘 | Bennasser Y Le S Y Yeung M L | 2004 | Retrovirology2004，1，： | 1 |
| 11 | Changes in microRNA expression profiles in HIV-l-transfected human cells 显示文摘 | Yeung ML Bennasser Y Myers TG | 2005 | Retrovirology2005，2，： | 1 |
| 12 | Roles for microRNAs,miR-93and miR-130b,and tumor protein 53-induced nuclear protein 1tumor suppressor in cell growth dysregulation by human T-cell lymphotrophic virus 1显示文摘 | YEUNG M L YASUNAGA J BENNASSER Y | 2008 | Cancer Res2008，68，： | 1 |
| 13 | HIV-1 encoded candidate microRNAs and their cellular targets 显示文摘 | Bennasser Y Le S Y Yeung M | 2004 | Retrovirology2004，1，1： | 1 |
| 14 | Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing显示文摘 | Bennasser Y Le S Y Benkirane M | 2005 | Immunity2005，22，： | 1 |
| 15 | HIV-1 encoded candidate micro-RNAs and their cellular targets显示文摘 | Bennasser Y Le SY Yeung ML | 2004 | Retrovirology2004，1，1： | 1 |
| 16 | Changes in microRNA expression profiles in HIV-1-transfected human cells显示文摘 | Yeung M L Bennasser Y Myers T G | 2005 | Retrovirology2005，2，： | 1 |
| 17 | Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing显示文摘 | Bennasser Y Le SY Benkirane M | 2005 | Immunity2005，22，5： | 1 |
| 18 | HIV-1 TAR RNA subverts RNA interference in transfected cells through sequestration of TAR RNA-binding protein,TRBP显示文摘 | Bennasser Y Yeung M L Jeang K T | 2006 | J Biol Chem2006，，27： | 1 |
| 19 | HIY-1 en- coded candidate micro-RNAs and their cellular targets 显示文摘 | BENNASSER Y LE S Y Man L Y | 2004 | Retrovirology2004，1，1： | 1 |
| 20 | HIV-1 encoded candidate micro-RNAs and their cellular targets 显示文摘 | BENNASSER Y LE S Y YEUNG M L | 2004 | Retrovirology2004，1，： | 1 |
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