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| 1 | HUMAN IMPACTS HAVE SHAPED HISTORICAL AND RECENT EVOLUTION IN AEDES AEGYPTI , THE DENGUE AND YELLOW FEVER MOSQUITO显示文摘 | Julia E. Brown Benjamin R. Evans Wei Zheng Vanessa Obas Laura Barrera‐Martinez Andrea Egizi Hongyu Zhao Adalgisa Caccone Jeffrey R. Powell | 2014 | Evolution2014，，： | 1 |
| 2 | Enhancing food safety culture to reduce rates of foodborne illness显示文摘 | Powell Douglas A Jacob Casey J Chapman Benjamin J | | 0，，06： | 1 |
| 3 | The Economics of Inclusionary Zoning Reclaimed: How effective are price controls? 显示文摘 | Powell Benjamin Stringham Edward | 2005 | Florida State University Law Review2005，，33： | 1 |
| 4 | Expression of the cytoskeleton linker protein ezrin in human cancers显示文摘 | Benjamin Bruce Gaurav Khanna Ling Ren Goran Landberg Karin Jirstr?m Charles Powell Alain Borczuk Evan T. Keller Kirk J. Wojno Paul Meltzer Kristin Baird Andrea McClatchey Anthony Bretscher Stephen M. Hewitt Chand Khanna | 2007 | Clinical & Experimental Metastasis2007，，2： | 1 |
| 5 | Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease显示文摘 | Powell TM Paul JD Hill JM Thompson M Benjamin M Rodrigo M | 2005 | Arterioscler Thromb Vasc Biol2005，25，2： | 1 |
| 6 | State Development Planning: Did It Create an East Asian Miracle显示文摘 | Benjamin Powell | 2005 | The Review of Austrian Eco- nomics2005，，18： | 1 |
| 7 | State Development Planning: Did It Create an East Asian Miracle 显示文摘 | Benjamin Powell | 2005 | The Review of Austrian Economics2005，，18： | 1 |
| 8 | Involvement of CRF2 signaling in enterocyte differentiation显示文摘AIM To determine the role of corticotropin releasing factor receptor(CRF2) in epithelial permeability and enterocyte cell differentiation. METHODS For this purpose,we used rat Sprague Dawley and various colon carcinoma cell lines(SW620,HCT8 R,HT-29 and Caco-2 cell lines). Expression of CRF2 protein was analyzed by fluorescent immunolabeling in normal rat colon and then by western blot in dissociated colonic epithelial cells and in the lysates of colon carcinoma cell lines or during the early differentiation of HT-29 cells(ten first days). To assess the impact of CRF2 signaling on colonic cell differentiation,HT-29 and Caco-2 cells were exposed to Urocortin 3 recombinant proteins(Ucn3,100 nmol/L). In some experiments,cells were pre-exposed to the astressin 2b(A2b) a CRF2 antagonist in order to inhibit the action of Ucn3. Intestinal cell differentiation was first analyzed by functional assays: the trans-cellular permeability and the para-cellular permeability were determined by Dextran-FITC intake and measure of the transepithelial electrical resistance respectively. Morphological modifications associated to epithelial dysfunction were analyzed by confocal microscopy after fluorescent labeling of actin(phaloidin-TRITC) and intercellular adhesion proteins such as E-cadherin,p120 ctn,occludin and ZO-1. The establishment of mature adherens junctions(AJ) was monitored by following the distribution of AJ proteins in lipid raft fractions,after separation of cell lysates on sucrose gradients. Finally,the m RNA and the protein expression levels of characteristic markers of intestinal epithelial cell(IEC) differentiation such as the transcriptional factor krüppel-like factor 4(KLF4) or the dipeptidyl peptidase IV(DPPIV) were performed by RT-PCR and western blot respectively. The specific activities of DPPIV and alkaline phosphatase(AP) enzymes were determined by a colorimetric method. RESULTS CRF2 protein is preferentially expressed in undifferentiated epithelial cells from the crypts of colon and in human colon carcinoma cell lines. Furthermore,CRF2 expression is down regulated according to the kinetic of HT-29 cell differentiation. By performing functional assays,we found that Ucn3-induced CRF2 signaling alters both para-and trans-cellular permeability of differentiated HT-29 and Caco-2 cells. These effects are partly mediated by Ucn3-induced morphological changes associated with the disruption of mature AJ in HT-29 cells and tight junctions(TJ) in Caco-2 cells. Ucn3-mediated activation of CRF2 decreases m RNA and protein expression levels of KLF4 a transcription factor involved in IEC differentiation. This signaling is correlated to a down-regulation of key IEC markers such as DPPIV and AP,at both transcriptional and posttranscriptional levels. CONCLUSION Our findings suggest that CRF2 signaling could modulate IEC differentiation. These mechanisms could be relevant to the stress induced epithelial alterations found in inflammatory bowel diseases. | Benjamin Ducarouge Marjolaine Pelissier-Rota Rebecca Powell Alain Buisson Bruno Bonaz Muriel Jacquier-Sarlin | 2017 | World Journal of Gastroenterology2017，23，28： | 1 |
| 9 | Cardiovascular Disease Mortality in Asian Americans显示文摘 | Powell O. Jose Ariel T.H. Frank Kristopher I. Kapphahn Benjamin A. Goldstein Karen Eggleston Katherine G. Hastings Mark R. Cullen Latha P. Palaniappan | 2014 | Journal of the American College of Cardiology2014，，： | 1 |
| 10 | Economic Freedom and Entrepreneurship: A Panel Study of the United States 显示文摘 | Powell Benjamin Weber Rick | 2013 | American Journal of Entrepreneurship2013，6，1： | 1 |
| 11 | Gene Expression in Wilms’ Tumor Mimics the Earliest Committed Stage in the Metanephric Mesenchymal-Epithelial Transition显示文摘 | Chi-Ming Li Meirong Guo Alain Borczuk Charles A. Powell Michelle Wei Harshwardhan M. Thaker Richard Friedman Ulf Klein Benjamin Tycko | 2002 | The American Journal of Pathology2002，，6： | 1 |
| 12 | State Development Planning:Did it Create anEast Asian Miracle显示文摘 | Benjamin Powell | | 0，，： | 1 |
| 13 | Enhancing food safety culture to reduce rates of foodbome illness显示文摘 | DOUGLAS A POWELL CASEY j JACOB BENJAMIN jCHAPMAN | 2011 | Food Journal2011，，9： | 1 |
| 14 | Granulocyte colony-stimulating factor mobilizes functional endothelialprogenitor cells in patients with coronary artery disease显示文摘 | Powell TM Paul JD Hill JM Thompson M Benjamin M Rodrigo M | 2005 | Arterioscler Thromb Vasc Biol2005，5，2： | 1 |
| 15 | Effects of task interdependence on the relationship between helping behavior and group performance显示文摘 | DANIEL G BACHRACH BENJAMIN C POWELL BRIAN J COLLINS | 2006 | J Appl Psychol2006，91，13： | 1 |
| 16 | Enhancing food safety culture to reduce rates of food- borne illness 显示文摘 | DOUGLAS A POWELL A CASEY J JACOB A BENJAMIN J CHAPMAN B | 2011 | Food Control2011，，22： | 1 |
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