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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Effect β-glucan from oat and yeast on serum lipids显示文摘 | Bell S Coldmanm V M Bistrian B R | 1999 | Critical reviews in food science and nutrition1999，39，： | 1 |
| 3 | Involvenrent of NF-kappa B signalling in skin physiology and disease显示文摘 | Bell S Degitz K Quirling M | 2003 | Cell Signal2003，15，1： | 1 |
| 4 | Synthesis and characterization of polypyrrole-magnetite-silica particles显示文摘 | Btterworth M D Bell S A Armes S P Simpson A W | 1996 | J Colloid Interf Sci1996，183，： | 1 |
| 5 | Analysis of fMRI data by blind separation into independent spatial components 显示文摘 | Mckeown M J Makelg S Brown G G Jung T P Kinderman S S Bell A J and Sejnowski T J | 1998 | Human Brain Mapping1998，6，： | 1 |
| 6 | Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins显示文摘 | Jantzen H M Admon A Bell S P | 1990 | Nature1990，344，： | 1 |
| 7 | Delta opioid receptor stimulation mimics ischemic preconditioning in human heart muscle显示文摘 | BELL S P SACK M N PATEL A | 2000 | J Am Coll Cardiol2000，36，7： | 1 |
| 8 | Evaluation of two post core systems using two different methods( fracture strength test and a finite elemental stress analysis ) 显示文摘 | Eskitaseioglu G Bell S Kalkan M | 2002 | J Endod2002，28，9： | 1 |
| 9 | What is the role of working memory in reading relative to the big three procession variables ( orthography, phonology, and rapid na- ming) 显示文摘 | McCallum R S Bell S M Wood M S | 2006 | Journal of Psycho -educational Assessment2006，24，： | 1 |
| 10 | SIRT3 suppresses hypoxia inducible factor la and tumor growth by inhibiting mitochondrial ROS production 显示文摘 | Bell E L Emerling B M Rieoult S J | 2011 | Oncogene2011，30，26： | 1 |
| 11 | Androgens stimulate gonadotropin-II beta-subunit in eel pituitary cells in vitro 显示文摘 | Huang Y S Schmitz M Le Belle N | 1997 | Molecular and Cellular Endocrinology1997，131，2： | 1 |
| 12 | Increased brain edema in aqp4-null mice in an experimental model of subarachnoid hemorrhage显示文摘 | TAIT M J SAADOUN S BELL B A etal | 2010 | Neuroscience2010，167，1： | 1 |
| 13 | Hepatic de novo lipogenesis in stable low-birth-weight infants during exclusive breast milk feedings and during parenteral nutrition 显示文摘 | Garg M Bassilian S Bell C | 2005 | JPEN J Parenter Enteral Mutr2005，29，2： | 1 |
| 14 | Development and application of molecular marker linkage maps in woody fruit crops显示文摘 | N F Weeden M Hemmatt D M Lawson M Lodhi R L Bell A G Manganaris B I Reischs S K Brown G N Ye | 1994 | Euphytica1994，77，12： | 1 |
| 15 | Use of molecular markers in a breeding program for Corus florida显示文摘 | Trigiano R N Schlarbaum S E Bell L M | 1996 | Proc Southern Nurseryman’s Res Conf1996，41，： | 1 |
| 16 | Evaluation of a Treponema pallidum Western immunoblot assay as a confirmatory test for syphilis显示文摘 | Byrne R E Laska S Bell M | 1992 | J Clin Microbiol1992，30，： | 1 |
| 17 | The phase II urokinase-streptokinase pulmonary embolism trial: a national cooperative study显示文摘 | Sasahra A A Bell W R Simon T L Stengle J M Sherry S | 1975 | Thromb Diath Haemorrh1975，33，： | 1 |
| 18 | Delta opioid receptor stimulation mimics ischemic preconditioning in human heart muscle 显示文摘 | Bell S P Sack M N Patel A | 2000 | J Am Coil Cardiol2000，36，7： | 1 |
| 19 | The optimisation of traffic count locations in road networks 显示文摘 | EHLERT A BELL M G H GROSSO S | 2006 | Transportation Research Part B2006，40，6： | 1 |
| 20 | Air temperature and winter mortality: implications for the persistence of the invasive mussel, Perna viridis in the intertidal zone of the south- eastern United States显示文摘 | Firth L B Knights A M Bell S S | 2011 | J Experim Mar Biol Ecol2011，400，25： | 1 |
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