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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Diuretics:1,2,4-Benzothiadiazine-1,1-Dioxides显示文摘 | NoveUo F C Bell S C Abram s E L A | 1960 | J Org Chem1960，25，6： | 1 |
| 3 | The interaction of two parallel non-coplanar identical surface cracks under tension and bending显示文摘 | Moussa W A Bell R Tan C L | 1999 | International Journal of Pressure Vessels and Piping1999，79，3： | 1 |
| 4 | Prothrombotic and pro-oxidant effects of diet-induced hyperhomo-cysteinemial显示文摘 | SAULS D L ARNOLD E K BELL C W | 2007 | Thromb Res2007，120，1： | 1 |
| 5 | Autooxidation of oil emulsions during the Artemia enrichment process显示文摘 | Mcevoy L A Navarro J C Bell J G | 1995 | Aquaculture1995，134，12： | 1 |
| 6 | XPD codon 751 polymorphism,metabolism genes,smoking,and bladder cancer risk显示文摘 | STERN M C JOHNSON L R BELL D A | 2002 | Cancer Epidemiol Biomarkers Prev2002，11，101： | 1 |
| 7 | The Densification of Granular Soils Using Vibro methods 显示文摘 | Slocomb B C Bell A L Baez J I | 2000 | Geotechnique2000，50，6： | 1 |
| 8 | Modulation of drug permeation through interpolymer complexed hydrogels for drug delivery applications显示文摘 | Bell C L Peppas N A | 1996 | J Controlled Release1996，39，： | 1 |
| 9 | Endophytic bacteria in graperine显示文摘 | Bell C R Dickie G A Harvey W L G | 1995 | Can J Microbiol1995，41，： | 1 |
| 10 | Restocking and stock enhancement of marine invertebrate fisheries显示文摘 | Bell J D Rothlisberg P C Munro J L | 2005 | Adv Mar Biol2005，49，： | 1 |
| 11 | Soil acidification and the carbon cycle in a cropping soil of north- eastern Victoria显示文摘 | Slattery W J Edwards D G Bell L C | 1998 | Australian Journal of Soil Research1998，36，2： | 1 |
| 12 | Characterization of nova plasmas using an X-ray spectrometer with temporal and spatial resolution显示文摘 | BACK C A AUFFMAN R L K BELL P M | 1995 | Review of Scientific Instruments1995，66，1： | 1 |
| 13 | Water,solute and protein diffusion in physiologically responsive hydrogels of poly(methacrylic acid-g-ethylene glycol)显示文摘 | Bell C L Peppas N A | 1996 | Biomaterials1996，17，： | 1 |
| 14 | The effects of triangle inequality on the vehicle routing problem显示文摘 | Fleming C L Griffis S E Bell J E | 2013 | European Journal of Operational Research2013，224，1： | 1 |
| 15 | Co-treatmentwithMK-801potentiates naloxone-precipitated morphine withdrawal in the isolated spinal cord of the neonatal rat显示文摘 | Bell J A Beglan C L | 1995 | Eur JPharmacol1995，294，1： | 1 |
| 16 | A market share theorem显示文摘 | BELL D E R L KEENEY J D C LITTLE | 1975 | Journal of Marketing Research1975，12，2： | 1 |
| 17 | Accumulation of hydroxyproline-rich glycoprotein mRNAs in response to fungal elicitor and infection显示文摘 | Showalter A M Bell J N Cramer C L | 1985 | Proc Natl Acad Sci USA1985，82，19： | 1 |
| 18 | Leading Practice Sustainable Development Program for the Mining Industry, Commonwealth Department of Industry, Tourism and Resources 显示文摘 | Bell L C | 2006 | Mine Closure and Completion2006，，10： | 1 |
| 19 | Plant uptake and Ph ytotoxicity of boron in Australian fly ashes显示文摘 | Bell L C | 1985 | Plant and Soil1985，84，： | 1 |
| 20 | The mode of antimicrobial action of the essential oil of Melaleuca alternifolia (tea tree oil) 显示文摘 | Cox S Mann C M Markham J L Bell H C Gustafson J E Warmington J R Wyllie1 S G | 2000 | Journal of Applied Microbiology2000，88，1： | 1 |
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