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23篇 您的检索式：作者名="Bath M L"

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	题名	作者	年代	出处	被引量
1	Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides.	John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin	2015	World Journal of Gastroenterology2015，21，35：	3
2	Bmi1 transgene induces lymphomas and collaborates with myc in tumorigenesis显示文摘	Haupt Y Bath M L Harris A W 	1993	Oncogene1993，8，11：	1
3	Bmi1 transgene induces lymphomas and collaborates with myc in tumorigenesis显示文摘	Haupt Y Bath M L Harris A W 	1993	Oncogene1993，8，11：	1
4	Bmi1 transgene induces lymphomas and collaborates with myc in tumorigenesis显示文摘	Haupt Y Bath M L Harris A W 	1993	Oncogene1993，8，11：	1
5	Caloric equivalent of live weight loss of dairy cattle显示文摘	Th Bath D L Ronning M Meyer J H	1965	J Dairy Sci1965，48，：	1
6	Influence of platelet size on outcome after myocardial infarction 显示文摘	MARTIN J F BATH P M BURR M L	1991	Lancet1991，338，8780：	1
7	Influence of platelet size on outcome after myocardial infarction 显示文摘	MARTIN J F BATH P M BURR M L	1991	Lanet1991，338，8780：	1
8	Strain induced crystallization in stereoregular polynetworks显示文摘	KUO C M BATHES K P MILLER R L	1997	Rub Chem and Tech1997，70，5：	1
9	Evaluation of the imaging properties of two generations of a CCD based system for digital chest radiography显示文摘	Bath M Sund P Mansson L G	2002	Med Phys2002，29，：	1
10	Multistep DNA-templated reactions for the synthesis of functional sequence controlled oligomers 显示文摘	Mckee M L Milnes P J Bath J	2010	Angew Chern Int Ed2010，49，43：	1
11	Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene显示文摘	Bodrug S E Warner B J Bath M L	1994	EMBO J1994，13，9：	1
12	A dominant interfering mutant of FADD/MORTI enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes 显示文摘	Newton K Harris A W Bath M L	1998	EMBO J1998，17，3：	1
13	Bmi-1 transgene in- duces lymphomas and collaborates with myc in tumorigenesis 显示文摘	Haupt Y Bath M L Harris A W	1993	Oncogene1993，8，：	1
14	Higher-order MITC general shell elements 显示文摘	Bucalem M L Bathe K J	1993	International Journal for Numerical Methods in Engineering1993，36，21：	1
15	Monte Carlo simulations of the dosimetry of chest tomosynthesis显示文摘	Svalkvist A Mansson L G Bath M	2010	Radiat Prot mosimetry2010，139，123：	1
16	A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes end inhibits proliferation of mature T lymphocytes显示文摘	Newton K Harris A W Bath M L	1998	EMBO J1998，17，3：	1
17	Novel primitive lymphoid tumours induced in transgenic mice by cooperation between Myc and Bcl-2显示文摘	Harris A W Bath M L	1990	Nature1990，348，6299：	1
18	Effects of NXY-059 in experimental stroke: an individual animal meta- analysis 显示文摘	BATH P M W GRAY L J BATH A J G	2009	Brit J Pharmacol2009，157，7：	1
19	P-selectin,tissue factor and CD40 ligand expression on platelet-leucocyte conjugates in the presence of a GPⅡb/Ⅲa antagonist显示文摘	Zhao L Bath P M May J		0，，7：	1
20	A dominant interfering mutant of FADD/MORTI enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes显示文摘	Newton K Harris A W Bath M L	1998	EMBO J1998，17，3：	1

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