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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | Is dynamic two-dimensional anal ultrasonography useful in the assessment of anismus? A comparison with manometry 显示文摘 | Murad-Regadas SM Regadas FS Barreto RG | 2010 | Arq Gastroenterol2010，47，4： | 1 |
| 3 | Risk of death from motor-vehicle injuryin Brazilian steel workers: a nested casecontrol study 显示文摘 | Barreto SM Swerdlow AJ Smith PG | 1995 | Int J Epidemiol1995，26，： | 1 |
| 4 | BCG vaccine: efficacy and indications for vaccination and revaccination 显示文摘 | Barreto ML Pereira SM Ferreira AA | 2006 | J Pediatr ( Rio J)2006，82，3： | 1 |
| 5 | Protection against dengue type 2 virus induced in mice immunized with a DNA plasmid encoding the nonstructural 1 ( NSI ) gene fused to the tissue plasminogen activator signal sequence显示文摘 | Costa SM Paes MV Barreto DF | 2006 | Vaccine2006，24，2： | 1 |
| 6 | Relations of dig- ital vascular function, cardiovascular risk factors, and? arteri- al stiffness: the Brazilian Longitudinal Study of Adult Health (ELSA Brasil) cohort study 显示文摘 | Brant LC Hamburg NM Barreto SM | 2014 | J Am Heart Assoc2014，3，00： | 1 |
| 7 | Earlier age at menarche is associated with higher diabetes risk and cardiometabolic diseaserisk factors in Brazilian adults:Brazilian longitudinal study of adult health (ELSA Brasil) 显示文摘 | Mueller NT Duncan B Barreto SM | 2014 | Cardiovascular Diabetology2014，13，1： | 1 |
| 8 | The control of schistosomiasis in Brazil:an ethnoepidemiological study of the effectiveness of a community mobilization program for health education显示文摘 | Uchoa E Barreto SM Firmo JO | 2000 | SocSciMed2000，51，10： | 1 |
| 9 | Epidemiology ofrecurrent venous thrombosis 显示文摘 | Ribeiro DD Lijfering WM Barreto SM | 2012 | Braz J Med Biol Res2012，45，1： | 1 |
| 10 | Smoking-attributable mortality and years of potential life lost in 16 Brazilian capitals, 2003: a prevalence-based study显示文摘 | Corrga PC Barreto SM Passos VM | 2009 | BMC Public Health2009，26，9： | 1 |
| 11 | Earlier age at menarche is associated with higher diabetes risk and car- diometabolic disease risk factors in Brazilian adults:Bra- zil/an Longitudinal Study of Adult Health (ELSA-Brasil) 显示文摘 | Mueller NT Duncan BB Barreto SM | 2014 | Cardiovasc Diabetol2014，13，1： | 1 |
| 12 | Reproducibility of pe-ripheral arterial tonometry for the assessment of endothelial func-tion in adults显示文摘 | Brant LC Barreto SM Passos VM | 2013 | J Hypertens2013，31，10： | 1 |
| 13 | Effectiveness and cost- effectiveness of first BCG vaccination against tuberculosis in school-age children without previous tuberculin test (BCG- REVAC trial):a cluster-randomized trial显示文摘 | Pereira SM Barreto ML Pilger D | 2012 | Lancet Infect Dis2012，12，4： | 1 |
| 14 | Liver injury and viremia in mice infected with dengue-2 virus 显示文摘 | Paes MV Pinhao AT Barreto DF Costa SM Oliveira MP Nogueira AC Takiya CM Farias-Filho JC Schatzmayr HG Alves AM Barth OM | 2005 | Virology2005，338，2： | 1 |
| 15 | Effect of BCG revaccination on incidence of tuberculosis in school-aged children in Brazil:the BCGREVAC cluster-randomised trial显示文摘 | Rodrigues LC Pereira SM Cunha SS Genser B Ichihara MY de Brito SC Hijar MA Dourado I Cruz AA Sant'Anna C Bierrenbach AL Barreto ML | 2005 | Lancet2005，366，9493： | 1 |
| 16 | Risk of death from motor-vehicle injury in Brazilian steelworkers:A nested case-control study显示文摘 | Barreto SM Swerdlow AJ Smith PG | 1997 | Int J Epidemiol1997，26，： | 1 |
| 17 | One-year follow-up of the effects of sildenafil on pulmonary arterial hypertension and veno- occlusive disease显示文摘 | Barreto AC Franchi SM Castro CR | 2005 | Braz J Med Biul Res2005，38，2： | 1 |
| 18 | Hepatitis B vaccination among dentists surgeons显示文摘 | Martins AM Barreto SM | 2003 | Rev Saude Publica2003，37，3： | 1 |
| 19 | Risk of death from motor vehicle injury in Brazilian steel workers:A nested case-control study显示文摘 | Barreto SM Swerdlow A J Smith PG | 1997 | Int J Epidemiol1997，26，4： | 1 |
| 20 | BCG vaccine:efficacy and indications for vaccination and revaccination 显示文摘 | Barreto ML Pereira SM Ferreira AA | 2006 | J Pediatr(Rio J)2006，82，3： | 1 |
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