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| 1 | Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response显示文摘AIM: To investigate the co-incidence of apoptosis, autophagy, and unfolded protein response(UPR) in hepatitis B(HBV) and C(HCV) infected hepatocytes.METHODS: We performed immunofluorescence confocal microscopy on 10 liver biopsies from HBV and HCV patients and tissue microarrays of HBV positive liver samples. We used specific antibodies for LC3β, cleaved caspase-3, BIP(GRP78), and XBP1 to detect autophagy, apoptosis and UPR, respectively. AntiHCV NS3 and anti-HBs antibodies were also used to confirm infection. We performed triple blind counting of events to determine the co-incidence of autophagy(LC3β punctuate), apoptosis(cleaved caspase-3), and unfolded protein response(GRP78) with HBV and HCV infection in hepatocytes. All statistical analyses were performed using SPSS software for Windows(Version 16 SPSS Inc, Chicago, IL, United States). P-values < 0.05 were considered statistically significant. Statistical analyses were performed with Mann-Whitney test to compare incidence rates for autophagy, apoptosis, and UPR in HBV- and HCV-infected cells and adjacent noninfected cells.RESULTS: Our results showed that infection of hepatocytes with either HBV and HCV induces significant increase(P < 0.001) in apoptosis(cleavage of caspase-3), autophagy(LC3β punctate), and UPR(increase in GRP78 expression) in the HCV- and HBVinfected cells, as compared to non-infected cells of the same biopsy sections. Our tissue microarray immunohistochemical expression analysis of LC3β in HBV^(Neg) and HBV^(Pos) revealed that majority of HBVinfected hepatocytes display strong positive stainingfor LC3β. Interestingly, although XBP splicing in HBVinfected cells was significantly higher(P < 0.05), our analyses show a slight increase of XBP splicing was in HCV-infected cells(P > 0.05). Furthermore, our evaluation of patients with HBV and HCV infection based on stage and grade of the liver diseases revealed no correlation between these pathological findings and induction of apoptosis, autophagy, and UPR.CONCLUSION: The results of this study indicate that HCV and HBV infection activates apoptosis, autophagy and UPR, but slightly differently by each virus. Further studies are warranted to elucidate the interconnections between these pathways in relation to pathology of HCV and HBV in the liver tissue. | Behzad Yeganeh Adel Rezaei Moghadam Javad Alizadeh Emilia Wiechec Seyed Moayed Alavian Mohammad Hashemi Bita Geramizadeh Afshin Samali Kamran Bagheri Lankarani Martin Post Payam Peymani Kevin M Coombs Saeid Ghavami | 2015 | World Journal of Gastroenterology2015，21，47： | 13 |
| 2 | An artificial immune algorithm for the flexible job-shop scheduling problem 显示文摘 | BAGHERI A ZANDIEH M MAHDAVI I | 2010 | Future Generation Computer Systems2010，26，4： | 1 |
| 3 | Critical compo- nent identification in reliability centered asset management of power distribution systems via fuzzy AHP显示文摘 | Dehghanian P Fotuhi F M Bagheri S S | 2012 | IEEE Systems Journal2012，6，59： | 1 |
| 4 | Comparison of Mersilene mesh and autogenous fascia lata in correction of congenital blepharoptosis:a randomized clinical trial显示文摘 | Salour H Aletaha M Bagheri A | 2008 | Eur J Ophthalmol2008，18，： | 1 |
| 5 | Simultane- ous Removal of Heavy-metal Ions in Wastewater Samples Using Nano-alumina Modified with 2,4- Dinitrophenylhydrazine 显示文摘 | Afkhami A Saber-Tehrani M Bagheri H | 2010 | Journal of Hazardous Materials2010，181，13： | 1 |
| 6 | Solid phase extraction of gold by sorption on oetadecyl silica membrane disks modified with pentathia-15-crown-5 and determination by AAS 显示文摘 | Bagheri M Mashhadizader M H Razee S | 2003 | Talanta2003，60，： | 1 |
| 7 | Electrochemical synthesis of highly electro active polydiphenylamine/polybenzidine copolymer in aqueous solutions显示文摘 | Bagheri A Nateghi M R Massoumi A | 1998 | Synthetic Metals1998，97，： | 1 |
| 8 | Immobilizationreduces the activity of surface-bound cationicantimicrobial peptides with no influence upon the activityspectrum显示文摘 | Bagheri M Beyermann M Dathe M | 2008 | Antimicrobial Agents and Chemotherapy2008，53，3： | 1 |
| 9 | T cell cytokine polarity as a determinant of immunoglobulin A(Ig A)glycosylation and the severity of experimengtal Ig A nephropathy显示文摘 | Chintalacharuvu SR Yamashita M Bagheri N | 2008 | Clin Exp Immunol2008，153，3： | 1 |
| 10 | Interleukin-18, Interleukin-8, and CXCR2 and the risk of silicosis显示文摘 | Mohebbi I Rad IA Bagheri M | 2012 | Toxicology and Industrial Health2012，29，9： | 1 |
| 11 | Thermosensitive biotinylated hydroxypropyl cellulose-based polymer micelles as a nano-carrier for cancer-targeted drug delivery显示文摘 | BAGHERI M SHATERI S NIKNEJAD H | 2014 | Journal of Polymer Research2014，21，10： | 1 |
| 12 | Rheological char- acteristics of non-Newtonian nanofluids: experimental in- vestigation 显示文摘 | Hojjat M Etemad S Gh Bagheri R | 2011 | International Communications in Heat and Mass Transfer2011，38，： | 1 |
| 13 | Genistein a-meliorates learning and memory deficits in amyloid p ( 1 -40) rat model of Alzheimer’s disease 显示文摘 | Bagheri M Joghataei MT Mohseni S | 2011 | Neurobiol LearnMem2011，95，3： | 1 |
| 14 | Explosive scarf welding of aluminum to copper plates and their interface properties显示文摘 | Ashani J Z Bagheri S M | | 0，，09： | 1 |
| 15 | Frequency response anal- ysis and short-circuit impedance measurement in detection of winding deformation within power transformers显示文摘 | Bagheri M Naderi M S Blackburn T | 2013 | IEEE Electrical Insulation Magazine2013，29，3： | 1 |
| 16 | Late probing for con- genital nasolacrimal duct obstruction 显示文摘 | Abrishami M Bagheri A Salour SH | 2009 | J Ophthalmic Vis Res2009，4，2： | 1 |
| 17 | Advanced transformer winding deformation diagnosis: moving from off-line to on-line显示文摘 | Bagheri M Naderi M S Blackburn T | 2012 | IEEE Transactions on Dielectrics and Electrical Insulation2012，19，6： | 1 |
| 18 | Adipose tis- sue derived mesenchymal stem cell (AD-MSC) promotes skin wound healing in diabetic rats显示文摘 | Maharlooei MK Bagheri M Solhjou Z | 2011 | Diabetes Res Clin Pract2011，93，2： | 1 |
| 19 | Transport mode selection for toxic gases: rail or road?显示文摘 | Bagheri M Verma M Verter V | 2014 | Risk Analysis2014，34，1： | 1 |
| 20 | Preparation and characterization of cellu lose-ZnO nanocomposite based on ionic liquid (C1) 显示文摘 | Bagheri M Rabieh S | 2013 | Cellulose2013，20，2： | 1 |
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