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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Effect of organic produc-tion system on broiler carcass and meat quality显示文摘 | Castellini C M ugnai C Dal Bosco A | 2002 | Meat Sci2002，60，3： | 1 |
| 3 | Sequential kidney/islet transplantation:efficacy and safety assessment of a steroid-free immunosuppression protocol显示文摘 | Toso C Baertschiger R Morel P Bosco D Armanet M Wojtusciszyn A | | 0，，： | 1 |
| 4 | Effect of thalidomide and rosiglitazone on the prevention of diabetic retinopathy in streptozotocin-induced diabetic rats显示文摘 | Bosco A A Lerario A C Santos R F | 2003 | Diabetologia2003，46，12： | 1 |
| 5 | Effect of dietary α- linolenic acid and vitamin E on the fatty acid composition, storage stability and sensory traits of rabbit meat显示文摘 | Dal Bosco A Castellini C Bianchl L | 2004 | Meat Sci2004，66，： | 1 |
| 6 | Improvement of lipid stability of rabbit meat by vitamin E and C administration显示文摘 | CASTELLINI C BOSCO A BERNARDINI M | 2001 | Journal of the Science of Food and Agricultnre2001，81，1： | 1 |
| 7 | The tryptophan catabolite picolinic acid selectively in- duces the chemokines macrophage inflammatory pro- tein-la and -113 in macrophages显示文摘 | BOSCO M C RAPISARDA A MASSAZZA S | 2000 | The Journal of Im- munology2000，164，： | 1 |
| 8 | Effect of dietary a-linolenic acid and vitamin E on the fatty acid composition, storage stability and sensory traits of rabbit meat显示文摘 | dal BOSCO A CASTELLINI C BIANCHI L | 2004 | Meat Science2004，66，2： | 1 |
| 9 | Effect of organic productionsystem on broiler carcass and meat quality显示文摘 | CASTELLINI C MUGNAI C DAL BOSCO A | 2002 | Meat Sci2002，60，： | 1 |
| 10 | Efficient regeneration from cotyledon protoplasts in Arabidopsis thaliana显示文摘 | Dovzhenko A Dal Bosco C Meurer J | 2003 | Protoplasma2003，222，： | 1 |
| 11 | Cost of illness of hyponatremia in the United States显示文摘 | Boscoe A Paramore C Verbalis JG | | 0，，： | 1 |
| 12 | Effect of organic production system on broiler carcass and meat quality 显示文摘 | CASTELLINI C MUGNAL C BOSCO A D | 2002 | Meat Science2002，60，3： | 1 |
| 13 | Effect of organic pro- duction system on broiler carcass and meat quality显示文摘 | CasteUini C Mugnai C Dal Bosco A | 2002 | Meat Sci- ence2002，60，3： | 1 |
| 14 | Accumulative effects in temporal coherent control显示文摘 | FELINTO D BOSCO C A C ACIOLI L H | 2001 | Phys Rev A2001，64，06： | 1 |
| 15 | Effect of organic production system on broiler carcass and meat quality 显示文摘 | CASTELLINI C MUGNAL C BOSCO A D | 2002 | Meat Science2002，60，3： | 1 |
| 16 | Effect of organic production system on broiler carcass and meat quality显示文摘 | C Castellini C Mugnai A Dal Bosco | 2002 | Meat Science2002，60，： | 1 |
| 17 | Birth asphyxia : does the Apgar score have dignostic value 显示文摘 | Marrin M Frep C Bosco A | 1988 | Obstet Gynecol1988，72，： | 1 |
| 18 | Effect of dietary alfalfa on the fatty acid compositionand indexes of lipid metabolism of rabbit meat 显示文摘 | DAL BOSCO A MUGNAI C ROSCINI V | 2014 | Meat Science2014，96，1： | 1 |
| 19 | Incomplete entanglement: consequences for the quantum Zeno effect显示文摘 | Rossi R J Bosco A R Nemes M C | 2008 | Phys Rev A2008，78，04： | 1 |
| 20 | Bioremediation potential of ba~sidionmycetes isolated from compost显示文摘 | Anastasi A Varese G C Bosco F | 2008 | Bioresource Technology2008，99，14： | 1 |
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