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| 1 | Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer’s disease and dementia with Lewy bodies显示文摘Background:Because of the increasing life expectancy in our society,aging-related neurodegenerative disorders are one of the main issues in global health.Most of these diseases are characterized by the deposition of misfolded proteins and a progressive cognitive decline.Among these diseases,Alzheimer’s disease(AD)and dementia with Lewy bodies(DLB)are the most common types of degenerative dementia.Although both show specific features,an important neuropathological and clinical overlap between them hampers their correct diagnosis.In this work,we identified molecular biomarkers aiming to improve the misdiagnosis between both diseases.Methods:Plasma extracellular vesicles(EVs)-from DLB,AD and healthy controls-were isolated using size-exclusion chromatography(SEC)and characterized by flow cytometry,Nanoparticle Tracking Analysis(NTA)and cryo-electron microscopy.Next Generation Sequencing(NGS)and related bibliographic search was performed and a selected group of EV-associated microRNAs(miRNAs)was analysed by qPCR.Results:Results uncovered two miRNAs(hsa-miR-451a and hsa-miR-21-5p)significantly down-regulated in AD samples respect to DLB patients,and a set of four miRNAs(hsa-miR-23a-3p,hsa-miR-126-3p,hsa-let-7i-5p,and hsamiR-151a-3p)significantly decreased in AD respect to controls.The two miRNAs showing decreased expression in AD in comparison to DLB provided area under the curve(AUC)values of 0.9 in ROC curve analysis,thus suggesting their possible use as biomarkers to discriminate between both diseases.Target gene analysis of these miRNAs using prediction online tools showed accumulation of phosphorylation enzymes,presence of proteasome-related proteins and genes involved in cell death among others.Conclusion:Our data suggest that plasma-EV associated miRNAs may reflect a differential profile for a given dementia-related disorder which,once validated in larger cohorts of patients,could help to improve the differential diagnosis of DLB versus AD. | Ana Gámez-Valero Jaume Campdelacreu Dolores Vilas Lourdes Ispierto Ramón Reñé RamiroÁlvarez MPilar Armengol Francesc E.Borràs Katrin Beyer | 2019 | Translational Neurodegeneration2019，8，1： | 4 |
| 2 | Chin marking behav-ior, sexual receptivity, and pheromone emission in steroid-treated,ovariectomized rabbits显示文摘 | Hudson R Gonzalez-Mariscal G Beyer C | 1990 | Horm Behav1990，24，1： | 1 |
| 3 | Monitoring and remote failure detection of grid-connected PV systems based on satellite ob- servations显示文摘 | DREWS A KEIZER A C BEYER l-I G | 2007 | Solar Energy2007，81，： | 1 |
| 4 | Evolution strategies:a comprehensive introduction显示文摘 | Beyer H G Schwefel H E | 2002 | Natural Computing2002，1，： | 1 |
| 5 | Immunocytochemical detection of estrogen receptor-alpha in the female rabbit forebrain:nerve topography andregulation by estradiol显示文摘 | Caba M Beyer C Gonzalez-Mariscal G | 2003 | Neuroendocrinology2003，77，3： | 1 |
| 6 | On self-adapting features in real-parameter evolutionary algorithms显示文摘 | Beyer H G Deb K | 2001 | IEEE Transactions on Evolutionary Computation2001，5，3： | 1 |
| 7 | Smoking-related greater ves-sel stenoses and bilateral axillary artery revascularization显示文摘 | Baeza C R Beyer E Svensson L G | 2004 | Ann Thorac Surg2004，77，5： | 1 |
| 8 | Filler blend of carbon nanotubes and organoclays with improved char as a new flame retardant system for Polymers and cable applications显示文摘 | Beyer G | 2005 | Fire and Materials2005，29，： | 1 |
| 9 | Modifications of theHeliosat Procedure for Irradiance Estimates from Satellite Da-ta显示文摘 | Beyer H G Costanzo C Heinemann D | 1996 | Solar Energy1996，56，3： | 1 |
| 10 | Activation of pepsin by heavy mental ions including acontribution to the mode of action of copper sulfate in pig nutrition显示文摘 | KIRCHGESSNER M BEYER M G Steinhart H | 1976 | Br J Nutr1976，36，： | 1 |
| 11 | Short communication:Carbon nanotubes as flame retardants for polymers显示文摘 | Beyer G | 2002 | Fire and Matrials2002，26，6： | 1 |
| 12 | Flame retardancy of nanocomposites based on organoclays and carbon nanotubes with alurninium trihydrate 显示文摘 | Beyer G | 2006 | Polymers for Advanced Technologies2006，17，： | 1 |
| 13 | Self-Adaptive Genetic Algorithms with Simulated Binary Crossover 显示文摘 | Deb K Beyer H G | 2001 | Evolutionary Computation2001，9，2： | 1 |
| 14 | A mechanistic study of fire retardancy of carbon nanotube/ethylene vinyl acetate copolymers and their clay composites显示文摘 | Gao F G Beyer G Yuan Q C | 2005 | Polymer Degradation and Stability2005，89，3： | 1 |
| 15 | 显示文摘 | Gao F G Beyer G Yuan Q C | 2005 | Polymer Degradation and Stability2005，89，3： | 1 |
| 16 | Phospholipid transfer protein is regulated by liver X receptors in vivo 显示文摘 | Cao G Beyer TP Yang XP | 2002 | J Biol Chem2002，277，39： | 1 |
| 17 | Short Communication:Carbon Nanotubes as Flame Retardants for Polymers 显示文摘 | Beyer G | 2002 | Fireand Materials2002，26，： | 1 |
| 18 | Dual-modality PET/CT imaging:the effect of respiratory motion on combined image quality in clinical oncology 显示文摘 | Beyer T Antoch G Blodgett T | 2003 | Eur J Nucl Med2003，30，： | 1 |
| 19 | Polymer/carbon nanotube nanocomposites:Influence of carbon nanotubes on EVA photo degradation显示文摘 | Gao F Beyer G Yuan Q | 2005 | Polymer Degradation and Stability2005，89，3： | 1 |
| 20 | Preparation and properties of layered silicate nanocomposites based on ethylene vinyl acetate copolymers显示文摘 | ALEXANDRE M BEYER G HENRIST C | 2001 | Rapid Commun2001，22，： | 1 |
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