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| 1 | MicroRNAs as a potential prognostic factor in gastric cancer显示文摘AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer.METHODS:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was available.Total RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA fraction.Initial profiling using miR microarrays was performed to identify potential biomarkers of recurrence after resection.The expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and survival.Using miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis groups.CONCLUSION:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer.Of these,miR-451 had the strongest prognostic impact. | Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir | 2011 | World Journal of Gastroenterology2011，17，35： | 31 |
| 2 | Age at Onset Should Be a Major Criterion for Subclassification of Colorectal Cancer显示文摘 | José Perea Daniel Rueda Alicia Canal Yolanda Rodríguez Edurne álvaro Irene Osorio Cristina Alegre Bárbara Rivera Joaquín Martínez Javier Benítez Miguel Urioste | 2014 | The Journal of Molecular Diagnostics2014，，1： | 2 |
| 3 | Long-range order in nonporous hybrid organic-inorganic silicon-based materials by sol-gel processing 显示文摘 | Ben F Boury B Corriu R J P | 2002 | Adv Mater2002，14，15： | 1 |
| 4 | Simulation of IR images of natural backgrounds显示文摘 | Ben Y N Rahat B Feigin G | 1983 | Applied Optics1983，22，1： | 1 |
| 5 | Bioactive nanocrystalline sol-gel hydroxyapatite coatings显示文摘 | CHAI C S BEN NISSAN B | 1999 | Journal of Materials Science: Materi als in Medicine1999，10，8： | 1 |
| 6 | Sorption and mobility of pharmaceutical compounds in soil1 irrigated with reclaimed wastewater 显示文摘 | Chefetz B Mualem T Ben - Ari J | 2008 | Chemosphere2008，73，： | 1 |
| 7 | Characterization of Zireonia Films Deposited by RF Magnetron Sputtering 显示文摘 | Ben Amor S Rogier B Baud G | 1998 | Materials Science and Engineering: B1998，7，1： | 1 |
| 8 | Recent Humanto-Poultry Host Jump,Adaptation,and Pandemic Spread of Staphylococcus Aureus显示文摘 | LOWDER B V GUINANE C M BEN ZAKOUR NL | 2009 | Proc Natl Acad Sci U S A2009，106，19： | 1 |
| 9 | ILAE Treatment Guidelines:evidence-based analysis of antiepileptic drug efficacy andeffectiveness as initial monotherapy for epileptic seizures andsyndromes显示文摘 | Tracy G Ben M Blaise B | 2006 | Epilepsia2006，47，7： | 1 |
| 10 | Adaptive tracking control of uncer- tain MIMO nonlinear systems with input constraints 显示文摘 | CHEN M GE S S BEN B B | 2011 | Automatica2011，47，3： | 1 |
| 11 | Level of glycemic control and pregnancy outcome in type 1 diabetes: A comparison between multiple daily insulin injections and continuous subcutaneous insulin infusions显示文摘 | Chen R Ben H A Weismann B A | 2007 | Am J Obstet Gynecol2007，197，4： | 1 |
| 12 | Activation of signal transducers and activator of transcription 3 and overexpression of its target gene CyclinD1 in laryngeal carcinomas 显示文摘 | Liu B Ben z Shi Y | 2008 | Laryngoscope2008，118，11： | 1 |
| 13 | The tumor suppressor maspin mediates E2F1-induced sensitivity of cancer cells to chemotherapy显示文摘 | BEN SHACHAR B FELDSTEIN O HACOHEN D | 2010 | Mol Cancer Res2010，8，3： | 1 |
| 14 | Evaluation of different techniques for vaginoplasty in the treatment of Mayer-Rokitansky- Kuster-Hauser syndrome显示文摘 | Ben Hmid R Touhami O Zouaoui B | 2012 | Tunis Med2012，90，12： | 1 |
| 15 | Inhibition of virus replication by RNA interfernce显示文摘 | Haasnoot P C J Cupac D Ben B | 2003 | Biomed Sci2003，10，： | 1 |
| 16 | Intratheeal fentanyl with small-dose dilute bupivacaine: better anesthesia without prolonging recovery 显示文摘 | Ben David B Solomon E Levin H | 1997 | Anesth Analg1997，85，3： | 1 |
| 17 | Photochemical fate of atorvastatin (lipitor) in simulated natural waters显示文摘 | RAZAVI B BEN A S SONG W | 2011 | Water Research2011，45，2： | 1 |
| 18 | The syndrome of inappropriate antidiuretic hormone secretion inthe elderly显示文摘 | Hirshberg B Ben Yehuda A | 1997 | Am J Med1997，103，4： | 1 |
| 19 | Influence of de electric current on the hardness of thermally aged Cu-Cr-Zr alloy 显示文摘 | Wang Z J Zhong Y B Cao G H Wang C Wang J Ren W L Lei Z S Ben Z M | 2009 | Journal of Alloys and Compounds2009，479，： | 1 |
| 20 | Insulin Resistance, the Metabolic Syndrome, and Nonalcoholic Fatty Liver Disease显示文摘 | F Angelico M Del Ben R Conti S Francioso K Feole S Fiorello M G. Cavallo B Zalunardo F Lirussi C Alessandri F Violi | 2005 | The Journal of Clinical Endocrinology & Metabolism2005，，3： | 1 |
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