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| 1 | Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection显示文摘AIM: To test antibiotic-loaded coating for efficacy in reducing bacterial biofilm and development of osteomyelitis in an orthopaedic model of implant infection. METHODS: Phosphatidylcholine coatings loaded with 25% vancomycin were applied to washed and sterilized titanium wires 20 mm in length. A 10 mm segment was removed from rabbit radius(total = 9; 5 coated, 4 uncoated), and the segment was injected with 1 × 106 colony forming units(CFUs) of Staphylococcus aureus(UAMS-1 strain). Titanium wires were inserted throughthe intramedullary canal of the removed segment and into the proximal radial segment and the segment was placed back into the defect. After 7 d, limbs were removed, X-rayed, swabbed for tissue contamination. Wires were removed and processed to determine attached CFUs. Tissue was swabbed and streaked on agar plates to determine bacteriological score.RESULTS: Antibiotic-loaded coatings resulted in significantly reduced biofilm formation(4.7 fold reduction in CFUs; P < 0.001) on titanium wires and reduced bacteriological score in surrounding tissue(4.0 ± 0 for uncoated, 1.25 ± 0.5 for coated; P = 0.01). Swelling and pus formation was evident in uncoated controls at the 7 d time point both visually and radiographically, but not in antibiotic-loaded coatings.CONCLUSION: Active antibiotic was released from coated implants and significantly reduced signs of osteomyelitic symptoms. Implant coatings were well tolerated in bone. Further studies with additional control groups and longer time periods are warranted. Antibiotic-loaded phosphatidylcholine coatings applied at the point of care could prevent implant-associated infection in orthopaedic defects. | Jessica Amber Jennings Karen E Beenken Robert A Skinner Daniel G Meeker Mark S Smeltzer Warren O Haggard Karen S Troxel | 2016 | World Journal of Orthopedics2016，7，8： | 2 |
| 2 | Impact of sarA on daptomycin susceptibility of Staphylococcus aureus biofilms in vivo 显示文摘 | Weiss EC Zielinska A Beenken KE | 2009 | Antimierob Agents Chemother2009，53，10： | 1 |
| 3 | The FGF family: biology, pathophysiology and therapy显示文摘 | Beenken A Mohammadi M | 2009 | Nat Rev Drug Discov2009，8，3： | 1 |
| 4 | The FGF family: biology,pathophysiology and therapy 显示文摘 | BEENKEN A MOHAMMADI M | 2009 | Nat Rev Drug Discov2009，8，3： | 1 |
| 5 | Decreased FGF8 sig- naling causes deficiency of gonadotropin-releasing hormone in hu- mans and mice显示文摘 | Falardeau J Chung WC Beenken A | 2008 | J Clin Invest2008，118，8： | 1 |
| 6 | The FGF family: biology, pathophysiology and therapy 显示文摘 | Beenken A Mohammadi M | 2009 | Nat Rev Drug Discov2009，8，3： | 1 |
| 7 | Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hor- mone in humans and mice显示文摘 | Falardeau J Chung WC Beenken A | 2008 | J Clin Invest2008，118，8： | 1 |
| 8 | The FGF family: biology, pathophysiology and therapy显示文摘 | BEENKEN A MOHAMMADI M | 2009 | Nat Rev Drug Discoy2009，8，3： | 1 |
| 9 | The FGF family: biology, pathophysiology and therapy 显示文摘 | Beenken A Mohammadi M | 2009 | Nat Rev Drug Discov2009，8，3： | 1 |
| 10 | The FGF family:biology,pathophysiology and therapy显示文摘 | Beenken A Mohammadi M | 2009 | Nat Rev Drug Discov2009，8，3： | 1 |
| 11 | Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice显示文摘 | Falardeau J Chung WC Beenken A | 2008 | J Clin Invest2008，118，8： | 1 |
| 12 | Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice显示文摘 | Falardeau J Chung WC Beenken A | 2008 | J Clin Invest2008，118，8： | 1 |
| 13 | The FGF family: biology, pathophysiology and therapy显示文摘 | BEENKEN A MOHAMMADI M | 2009 | Nature Reviews Drug Disco- very2009，8，23： | 1 |
| 14 | Decreased FGF8 signsling causes deficiency of gonadotropin-releasing hormone in humans and mice显示文摘 | Falardeau J Chung WC Beenken A | 2008 | J Clin Invest2008，118，8： | 1 |
| 15 | T1 and T2 squamous cell carcinoma of oral tongue:prognostic factors and the role of elective lymph node dissection显示文摘 | Beenken S W Krontiras H Maddox W A | 1999 | Head Neck1999，21，2： | 1 |
| 16 | The FGF family:biology,pathophysiology and therapy显示文摘 | Beenken A Mohammadi M | 2009 | Nat Rev Drug Discov2009，8，3： | 1 |
| 17 | Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice显示文摘 | Falardeau J Chung W C Beenken A | 2008 | J Clin Invest2008，118，8： | 1 |
| 18 | The FGF family : biology, pathophysiol- ogy and therapy显示文摘 | Beenken A Mohammadi M | 2009 | Nat Rev Drug Discov2009，8，3： | 1 |
| 19 | The FGF Family: Bioloy, Pathophysiolog and Therapy 显示文摘 | Beenken A Mohammad M | 2009 | Nat Rev Drug Discov2009，8，3： | 1 |
| 20 | The FGF family: biology, pathophysiology and therapy 显示文摘 | Beenken A Mohammadi M | 2009 | Nat Rev Drug Diseov2009，8，3： | 1 |
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