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| 1 | Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection显示文摘AIM: To test antibiotic-loaded coating for efficacy in reducing bacterial biofilm and development of osteomyelitis in an orthopaedic model of implant infection. METHODS: Phosphatidylcholine coatings loaded with 25% vancomycin were applied to washed and sterilized titanium wires 20 mm in length. A 10 mm segment was removed from rabbit radius(total = 9; 5 coated, 4 uncoated), and the segment was injected with 1 × 106 colony forming units(CFUs) of Staphylococcus aureus(UAMS-1 strain). Titanium wires were inserted throughthe intramedullary canal of the removed segment and into the proximal radial segment and the segment was placed back into the defect. After 7 d, limbs were removed, X-rayed, swabbed for tissue contamination. Wires were removed and processed to determine attached CFUs. Tissue was swabbed and streaked on agar plates to determine bacteriological score.RESULTS: Antibiotic-loaded coatings resulted in significantly reduced biofilm formation(4.7 fold reduction in CFUs; P < 0.001) on titanium wires and reduced bacteriological score in surrounding tissue(4.0 ± 0 for uncoated, 1.25 ± 0.5 for coated; P = 0.01). Swelling and pus formation was evident in uncoated controls at the 7 d time point both visually and radiographically, but not in antibiotic-loaded coatings.CONCLUSION: Active antibiotic was released from coated implants and significantly reduced signs of osteomyelitic symptoms. Implant coatings were well tolerated in bone. Further studies with additional control groups and longer time periods are warranted. Antibiotic-loaded phosphatidylcholine coatings applied at the point of care could prevent implant-associated infection in orthopaedic defects. | Jessica Amber Jennings Karen E Beenken Robert A Skinner Daniel G Meeker Mark S Smeltzer Warren O Haggard Karen S Troxel | 2016 | World Journal of Orthopedics2016，7，8： | 2 |
| 2 | Extent of surgery for intermediate-risk well-differentiated thyroid cancer显示文摘 | Beenken S Roye D Weiss H | 2000 | The American journal of surgery2000，179，1： | 1 |
| 3 | Evaluation of dynamic - FDG - PET imaging for the detection of acute post - surgical bone infection 显示文摘 | Brown TL Spencer HJ Beenken KE | 2012 | PLoS One2012，7，41： | 1 |
| 4 | Molecular biomarkers for breastcancer prognosis:coexpression of c-erbB-2 and p53显示文摘 | Beenken SW Grizzle WE Crowe DR | 2001 | Ann Surg2001，233，5： | 1 |
| 5 | Impact of sarA on daptomycin susceptibility of Staphylococcus aureus biofilms in vivo 显示文摘 | Weiss EC Zielinska A Beenken KE | 2009 | Antimierob Agents Chemother2009，53，10： | 1 |
| 6 | Muhiplex PCR protocol for the diagnosis of staphylococcal infection 显示文摘 | Mason WJ Blevins JS Beenken K | 2001 | J Clin Microbiol2001，39，9： | 1 |
| 7 | The FGF family: biology, pathophysiology and therapy显示文摘 | Beenken A Mohammadi M | 2009 | Nat Rev Drug Discov2009，8，3： | 1 |
| 8 | Global geneexpression in Staphylococcus aureus biofilms 显示文摘 | Beenken KE Dunman PM McAleese F | 2004 | J Bacteriol2004，186，14： | 1 |
| 9 | The FGF family: biology,pathophysiology and therapy 显示文摘 | BEENKEN A MOHAMMADI M | 2009 | Nat Rev Drug Discov2009，8，3： | 1 |
| 10 | Defining the strain-dependent impact of the Staphylococcal accessory regulator (sarA) on the alpha-toxin phenotype of Staphylococcus aureus 显示文摘 | Zielinska AK Beenken KE Joo HS | 2011 | J Bacteriol2011，193，12： | 1 |
| 11 | Biomarkers for breast cancer显示文摘 | Beenken SW Bland KI | 2002 | Minerva Chir2002，57，4： | 1 |
| 12 | T1 and T2 squamous cell carcinoma of the oral tongue: prognostic factors and the role of elective lymph node dissection显示文摘 | Krontiras H | 1999 | Head Neck1999，21，2： | 1 |
| 13 | Chitosan coating to enhance the therapeutic efficacy of calcium sulfate-based antibiotic therapy in the treatment of chronic osteomyelitis显示文摘 | Beenken KE Smith JK Skinner RA | 2014 | J Biomater Appl2014，4，： | 1 |
| 14 | Global gene expression in Staphylococcus aureus biofilms 显示文摘 | Beenken K E Dunman P M McAleese F | 2004 | J Bacteriol2004，186，14： | 1 |
| 15 | Decreased FGF8 sig- naling causes deficiency of gonadotropin-releasing hormone in hu- mans and mice显示文摘 | Falardeau J Chung WC Beenken A | 2008 | J Clin Invest2008，118，8： | 1 |
| 16 | Prognosic factors in minor salivary gland cancer显示文摘 | Beenken SW Crowe R | 1995 | Head Neck1995，17，6： | 1 |
| 17 | The FGF family: biology, pathophysiology and therapy 显示文摘 | Beenken A Mohammadi M | 2009 | Nat Rev Drug Discov2009，8，3： | 1 |
| 18 | Spectroscopic units in conjugated polymers:a quantum chemically founded Concept显示文摘 | Beenken J D Pullerits T | 2004 | J Phys Chem B2004，108，20： | 1 |
| 19 | Global gene expression in Staphylococcus aureus biofilms 显示文摘 | Beenken K E Dunman P M McAleese F | 2004 | J Bacteriol2004，186，： | 1 |
| 20 | The electronic states of polyfluorene copolymers with alternatingdonor-acceptor units显示文摘 | Jespersen K G Beenken J D Zausjitsyn Y | 2004 | J Chem Phys2004，121，12： | 1 |
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