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| 1 | Role of PERK/eIF2α/CHOP Endoplasmic Reticulum Stress Pathway in Oxidized Low-density Lipoprotein Mediated Induction of Endothelial Apoptosis显示文摘Objective PERK/eI F2α/CHOP is a major signaling pathway mediating endoplasmic reticulum(ER) stress related with atherosclerosis.Oxidized LDL(ox-LDL) also induces endothelial apoptosis and plays a vital role in the initiation and progression of atherosclerosis.The present study was conducted to explore the regulatory effect of ox-LDL on PERK/e IF2α/CHOP signaling pathway in vascular endothelial cells.Methods The effects of ox-LDL on PERK and p-e IF2α protein expression of primary human umbilical vein endothelial cells(HUVECs) were investigated by Western blot analysis.PERK gene silencing and selective eI F2α phosphatase inhibitor,salubrinal were used to inhibit the process of ox-LDL induced endothelial cell apoptosis,caspase-3 activity,and CHOP mR NA level.Results Ox-LDL treatment significantly increased the expression of PERK,PERK-mediated inactivation of e IF2α phosphorylation,and the expression of CHOP,as well as the caspase-3 activity and apoptosis.The effects of ox-LDL were markedly decreased by knocking down PERK with stable transduction of lentiviral sh RNA or by selective eI F2α phosphatase inhibitor,salubrinal.Conclusion This study provides the first evidence that ox-LDL induces apoptosis in vascular endothelial cells mediated largely via the PERK/eI F2α/CHOP ER-stress pathway.It adds new insights into the molecular mechanisms underlying the pathogenesis and progression of atherosclerosis. | TAO Yong Kang YU Pu Lin BAI Yong Ping YAN Sheng Tao ZHAO Shui Ping ZHANG Guo Qiang | 2016 | Biomedical and Environmental Sciences2016，29，12： | 21 |
| 2 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 3 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 4 | Environmental Monitoring of A Laboratory for New Coronavirus Nucleic Acid Testing显示文摘The coronavirus disease 2019(COVID-19) is an infection of the respiratory tract which first broke out in Wuhan, China, in December 2019. The etiologic agent of this disease was identified as a betacoronavirus related to severe acute respiratory syndrome coronavirus(SARS-CoV). Thus, the International Committee on Virus Classification named the new coronavirus severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)[1]. | NING Pei Yong YU Ai Ping WANG Yuan GUO Li Ru SHAN Dan KONG Mei YU Ling Qi LYU Li Kun ZOU Ming SU Xu FEI Chun Nan ZHOU Yu Hui WANG Bai Qi | 2020 | Biomedical and Environmental Sciences2020，33，10： | 2 |
| 5 | A high-resolution cell atlas of the domestic pig lung and an online platform for exploring lung single-cell data显示文摘The genetically engineered pig is regarded as an optimal source of organ transplantation for humans and an excellent model for human disease research,given its comparable physiology to human beings.A myriad of single-cell RNA sequencing(sc RNA-seq)data on humans has been reported,but such data on pigs are scarce.Here,we apply sc RNA-seq technology to study the cellular heterogeneity of 3-month-old pig lungs,generating the single-cell atlas of 13,580 cells covering 16 major cell types.Based on these data,we systematically characterize the similarities and differences in the cellular cross-talk and expression patterns of respiratory virus receptors in each cell type of pig lungs compared with human lungs.Furthermore,we analyze pig lung xenotransplantation barriers and reported the cell-type expression patterns of 10 genes associated with pig-to-human immunobiological incompatibility and coagulation dysregulation.We also investigate the conserved transcription factors(TFs)and their candidate target genes and constructed five conserved TF regulatory networks in the main cell types shared by pig and human lungs.Finally,we present a comprehensive and openly accessible online platform,Scdb Lung.Our sc RNA-seq atlas of the domestic pig lung and Scdb Lung database can guide pig lung research and clinical applicability. | Lijing Zhang Jiacheng Zhu Haoyu Wang Jun Xia Ping Liu Fang Chen Hui Jiang Qiuling Miao Weiying Wu Lingli Zhang Lihua Luo Xiaosen Jiang Yong Bai Chengcheng Sun Dongsheng Chen Xingliang Zhang | 2021 | Journal of Genetics and Genomics2021，48，5： | 1 |
| 6 | Overweight, obesity and gastric cancer risk: Results from a meta-analysis of cohort studies显示文摘 | Ping Yang Yong Zhou Bo Chen Hong-Wei Wan Gui-Qing Jia Hai-Long Bai Xiao-Ting Wu | 2009 | European Journal of Cancer2009，，16： | 1 |
| 7 | 本校近期发表IF≥4.0的SCI论文摘要(英文)——RFXB and its splice variant RFXBSV mediate the antagonism between IFN gamma and TGF beta on COLIA2 transcription in vascular smooth muscle cells显示文摘 | Fang Mingming Kong Xiaocen Li Ping Fang Fei Wu Xiaoyan Bai Hui Qi Xiaohong Chen Qi Xu Yong | 2009 | 南京医科大学学报(自然科学版)2009，29，9： | 1 |
| 8 | The relationship between treatment-induced hypertension and efficacy of anlotinib in recurrent or metastatic esophageal squamous cell carcinoma显示文摘Objective:In this post-hoc analysis,we evaluated anlotinib treatment-induced hypertension as a potential predictive factor of efficacy in esophageal squamous cell carcinoma(ESCC)patients.Methods:A total of 109 patients enrolled in the anlotinib group in a phase 2 trial were included.The tumor response was assessed by computed tomography at week 3,week 6,and then every 6 weeks until progressive disease was observed.The primary endpoint of the study was progression free survival(PFS).The secondary endpoints included overall survival(OS)and objective response rate(ORR).Results:In all patients,the median PFS was 3.02 months[95%confidence interval(CI):2.63–3.65 months]and the OS was 6.11 months(95%CI:4.40–7.79 months).The ORR was 7.34%(95%CI:3.22%–13.95%).A total of 59(54%)patients were diagnosed with treatment-induced hypertension(Group A),and the remaining patients(n=50,46%)were in Group B.Baseline prognostic factors were similar between the 2 groups.Patients in Group A had a longer PFS and OS and higher ORR.When stratifying patients using a previously known history of hypertension,treatment-induced hypertension was a predictor only for patients without previous hypertension,who had longer PFS[hazard ratio(HR):0.40,95%CI:0.24–0.68]and OS(HR:0.37,95%CI:0.21–0.67).Conclusions:We showed,for the first time,a correlation between treatment-induced hypertension and better prognoses in recurrent or metastatic ESCC patients treated with anlotinib,without a previously known history of hypertension.Treatment-induced hypertension may be a simple and low cost predictor for anlotinib antitumor efficacy in these patients,which may also reflect the intended target inhibition. | Yan Song Juxiang Xiao Wentao Fang Ping Lu Qingxia Fan Yongqian Shu Jifeng Feng Shu Zhang Yi Ba Yang Zhao Ying Liu Chunmei Bai Yuxian Bai Yong Tang Jie He Jing Huang | 2021 | Cancer Biology & Medicine2021，18，2： | 1 |
| 9 | Aspirin Use and the Risk of Gastric Cancer: A Meta-Analysis显示文摘 | Ping Yang Yong Zhou Bo Chen Hong-Wei Wan Gui-Qing Jia Hai-Long Bai Xiao-Ting Wu | 2010 | Digestive Diseases and Sciences2010，，6： | 1 |
| 10 | A Novel Metal-organic Framework Using Heterometallic Tetranuclear Cluster as Secondary Building Block and Isophthalic Acid as Ligand显示文摘 | BAI Helong ZHANG Daojun ZHANG Renchun WANG Junjie ZENG Shuangli FAN Yong XU Jianing ZHANG Ping | 2016 | Chemical Research in Chinese Universities2016，32，5： | 1 |
| 11 | A new ent-abietane diterpenoid from Isodon macrophyllus显示文摘新 ent-abietane diterpenoid,命名 dayecrystal C,从 Isodon macrophyllus 的弄干的叶子的 EtOAc 摘录被孤立。它的结构根据分光镜的方法被决定。 | Zheng Yue Chen Pei Yong Qiu Yong Xue Wang Su Ping Bai Fu Lin Yan Ji Xia Zhang Han Dong Sun | 2008 | Chinese Chemical Letters2008，19，7： | 1 |
| 12 | Aspirin Use and the Risk of Gastric Cancer: A Meta-Analysis显示文摘 | Ping Yang Yong Zhou Bo Chen Hong-Wei Wan Gui-Qing Jia Hai-Long Bai Xiao-Ting Wu | 2010 | Digestive Diseases and Sciences2010，，6： | 1 |
| 13 | Single-cell RNA sequencing deciphers the mechanism of sepsis-induced liver injury and the therapeutic effects of artesunate显示文摘Liver,as an immune and detoxification organ,represents an important line of defense against bacteria and infection and a vulnerable organ that is easily injured during sepsis.Artesunate(ART)is an anti-malaria agent,that also exhibits broad pharmacological activities including anti-inflammatory,immune-regulation and liver protection.In this study,we investigated the cellular responses in liver to sepsis infection and ART hepatic-protective mechanisms against sepsis.Cecal ligation and puncture(CLP)-induced sepsis model was established in mice.The mice were administered ART(10 mg/kg,i.p.)at 4 h,and sacrificed at 12 h after the surgery.Liver samples were collected for preparing single-cell RNA transcriptome sequencing(scRNA-seq).The scRNA-seq analysis revealed that sepsis-induced a dramatic reduction of hepatic endothelial cells,especially the subtypes characterized with proliferation and differentiation.Macrophages were recruited during sepsis and released inflammatory cytokines(Tnf,Il1b,Il6),chemokines(Ccl6,Cd14),and transcription factor(Nfkb1),resulting in liver inflammatory responses.Massive apoptosis of lymphocytes and abnormal recruitment of neutrophils caused immune dysfunction.ART treatment significantly improved the survival of CLP mice within 96 h,and partially relieved or reversed the above-mentioned pathological features,mitigating the impact of sepsis on liver injury,inflammation,and dysfunction.This study provides comprehensive fundamental proof for the liver protective efficacy of ART against sepsis infection,which would potentially contribute to its clinical translation for sepsis therapy. | Xue-ling He Jia-yun Chen Yu-lin Feng Ping Song Yin Kwan Wong Lu-lin Xie Chen Wang Qian Zhang Yun-meng Bai Peng Gao Piao Luo Qiang Liu Fu-long Liao Zhi-jie Li Yong Jiang Ji-gang Wang | 2023 | Acta Pharmacologica Sinica2023，44，9： | 1 |
| 14 | Stereochemistry Control in Direct 1α-Hydroxylation of 5,6-trans-Vitamin D_(3) by Solid Support显示文摘A solid-phase synthesis of 1α-hydroxylation of 5,6-trans-vitamin D3 8 is described.The solid phase resin acts as a special protecting group, which gives a higher stereoselectivity inoxidation step than classical protecting groups. The stereochemistry control is favored by usinghigh crosslinkage polymer support in a poor solvent. This work may be of benefit to the synthesisof vitamin D system. | Yong Bin HAN Jin Ping CHEN Bai Ning LIU Guo Qiang YANG Yi LI | 2006 | Chinese Chemical Letters2006，17，2： | 0 |
| 15 | A Novel Low-frequency Radio Astronomical Observation Array(1~90 MHz)and its First Light显示文摘The extremely low frequency(f<40 MHz)is a very important frequency band for modern radio astronomy observations.It is also a key frequency band for solar radio bursts,planetary radio bursts,fast radio bursts detected in the lunar space electromagnetic environment,and the Earth’s middle and upper atmosphere with low dispersion values.In this frequency band,the solar stellar activity,the early state of the universe,and the radiation characteristics of the planetary magnetosphere and plasma layer can be explored.Since there are few observations with effective spatial resolution in the extremely low frequency,it is highly possible to discover unknown astronomical phenomena on such a band in the future.In conjunction with low frequency radio observation on the far side of the Moon,we initially set up a novel low-frequency radio array in the Qitai station of Xinjiang Astronomical Observatory deep in Tianshan Mountains,Xinjiang,China on 2021 August 23.The array covers an operating frequency range of 1~90 MHz with a sensitivity of-78 dBm/125kHz,a dynamic range of 72 dB,and a typical gain value of 6 dBi,which can realize unattended all-weather observations.The two antennas due south of the Qitai Low-Frequency Radio Array were put into trial observations on 2021 May 28,and the very quiet electromagnetic environment of the station has been confirmed.So far,many solar radio bursts and other foreign signals have been detected.The results show that this novel low frequency radio array has the advantages of good performance,strong direction,and high antenna efficiency.It can play a unique role in Solar Cycle 25,and has a potential value in prospective collaborative observation between the Earth and space for extremely low frequency radio astronomy. | Wen-Jun Yang Zhen Wang Ming-Yuan Wang Fa-Bao Yan Guang Lu Guan-Nan Gao Shao-Jie Guo Yu-Mei Shen Bing-Qiang Xu Yu Bai Yong Chen Jin-Song Ping | 2023 | Research in Astronomy and Astrophysics2023，23，12： | 0 |
| 16 | First report on establishment and characterization of the extrahepatic cholangiocarcinoma sarcoma cell line CBC2T-2显示文摘BACKGROUND Extrahepatic cholangiocarcinoma sarcoma is extremely rare in clinical practice.These cells consist of both epithelial and mesenchymal cells.Patient-derived cell lines that maintain tumor characteristics are valuable tools for studying the molecular mechanisms associated with carcinosarcoma.However,cholangiocarcinoma sarcoma cell lines are not available in cell banks.AIM To establish and characterize a new extrahepatic cholangiocarcinoma sarcoma cell line,namely CBC2T-2.METHODS We conducted a short tandem repeat(STR)test to confirm the identity of the CBC2T-2 cell line.Furthermore,we assessed the migratory and invasive properties of the cells and performed clonogenicity assay to evaluate the ability of individual cells to form colonies.The tumorigenic potential of CBC2T-2 cells was tested in vivo using nonobese diabetic/severe combined immunodeficient(NOD/SCID)mice.The cells were injected subcutaneously and tumor formation was observed.In addition,immunohistochemical analysis was carried out to examine the expression of epithelial marker CK19 and mesenchymal marker vimentin in both CBC2T-2 cells and xenografts.The CBC2T-2 cell line was used to screen the potential therapeutic effects of various clinical agents in patients with cholangiocarcinoma sarcoma.Lastly,whole-exome sequencing was performed to identify genetic alterations and screen for somatic mutations in the CBC2T-2 cell line.RESULTS The STR test showed that there was no cross-contamination and the results were identical to those of the original tissue.The cells showed round or oval-shaped epithelioid cells and mesenchymal cells with spindle-shaped or elongated morphology.The cells exhibited a high proliferation ratio with a doubling time of 47.11 h.This cell line has migratory,invasive,and clonogenic abilities.The chromosomes in the CBC2T-2 cells were polyploidy,with numbers ranging from 69 to 79.The subcutaneous tumorigenic assay confirmed the in vivo tumorigenic ability of CBC2T-2 cells in NOD/SCID mice.CBC2T-2 cells and xenografts were positive for both the epithelial marker,CK19,and the mesenchymal marker,vimentin.These results suggest that CBC2T-2 cells may have both epithelial and mesenchymal characteristics.The cells were also used to screen clinical agents in patients with cholangiocarcinoma sarcoma,and a combination of paclitaxel and gemcitabine was found to be the most effective treatment option.CONCLUSION We established the first human cholangiocarcinoma sarcoma cell line,CBC2T-2,with stable biogenetic traits.This cell line,as a research model,has a high clinical value and would facilitate the understanding of the pathogenesis of cholangiocarcinoma sarcoma. | Ning-Zu Jiang Ming-Zhen Bai Chong-Fei Huang Ze-Long Ma Ru-Yang Zhong Wen-Kang Fu Long Gao Liang Tian Ning-Ning Mi Hai-Dong Ma Ya-Wen Lu Zi-Ang Zhang Jin-Yu Zhao Hai-Ying Yu Bao-Ping Zhang Xian-Zhuo Zhang Yan-Xian Ren Chao Zhang Yong Zhang Ping Yue Yan-Yan Lin Wen-Bo Meng | 2023 | World Journal of Gastroenterology2023，29，41： | 0 |
| 17 | Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages显示文摘Dear Editor,SARS-CoV-2 rapidly evolves during the pandemic1 with many variants of concern(VoCs)lineages(Supplementary Fig.S1a).Omicron(B.1.1.529)and its sub-lineages led to multiple infection waves globally.2 Omicron subvariants harbored a high number of mutations,especially in the spike(S)glycoprotein,and clustered in the receptor-binding domain(RBD)(Supplementary Fig.S1b,c;Supplemental Discussion).These subvariants drastically decrease the efficacy of current vaccinations and monoclonal antibody therapies. | Ping Ren Yingxia Hu Lei Peng Luojia Yang Kazushi Suzuki Zhenhao Fang Meizhu Bai Liqun Zhou Yanzhi Feng Yongji Zou Yong Xiong Sidi Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，8： | 0 |
| 18 | THE SYNTHESIS OF UNSYMMETRIC ANALOGS OF GOSSYPOL—6-O-METHYLGOSSYPOL显示文摘6—O—Mcthylgossypol (3) was obtained with the methods of synthesis for the first time.For the purpose ofe一iminating some prob一ems assoeiatedwith the eliniea一use orgossypol such as irreversibility and hypokalemia,while retaining its pl飞armacologieally desirableantifertility effeets,numerous derivatives and | Hui Zhong XUE~*, Zheng Ming GUO. Ai Hua KONG and Guo Pci WU Nanjing Instilulc of Matcria Medica, Nanjing, 210009 Bai Yong MAO, Xiu Juan JIANG and Zhi Ping GU Shanghai Instilulc of Matcria Medica, Shanghai, 200031 | 1992 | Chinese Chemical Letters1992，3，3： | 0 |
| 19 | Convenient and Highly Efficient Inversion of 1β-OH Configuration of trans-Vitamin D_(3)显示文摘A convenient and highly efficient conversion of 1β-OH-trans-vitamin D3, a main byproduct in synthesis of active vitamin D3, to 1α-OH-trans-vitamin D3 is reported. The conversion could be accomplished in 1 minute with 90% yield. | Yong Bin HAN Jin Ping CHEN Ying Ying LI Bai Ning LIU Guo Qiang YANG Yi LI | 2005 | Chinese Chemical Letters2005，16，11： | 0 |
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