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| 1 | Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations显示文摘 | Thompson MC Fuller C Hogg TL Dalton J Finkelstein D Lau CC Chintagumpala M Adesina A Ashley DM KeUie SJ Taylor MD Curran T Gajjar A Gilbertson RJ | 2006 | 中国神经肿瘤杂志2006，4，1： | 17 |
| 2 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 3 | QTLs conditioning early growth in a soybean population segregation for growth habit 显示文摘 | Mian M A R Ashley D A Vencill WK et at | 1998 | Theoretical and Applied Genetics1998，97，8： | 1 |
| 4 | Environmental mobility of antimony around mesothermal stibnitedeposits, New South Wales, Australia and southern New Zealand 显示文摘 | ASHLEY P M CRAW D GRAHAM B P | 2003 | Journal of Geochemical Exploration2003，77，1： | 1 |
| 5 | An additional QTL for water use efficiency in soybean显示文摘 | MAIN M A R ASHLEY D BAILEY M A | 1998 | Crop Sci1998，38，： | 1 |
| 6 | Melecularmarkers associated with water use efficiency and leafash in soybean显示文摘 | MIAN M A R BAILEY M A ASHLEY D D | 1996 | Crop Sci1996，36，： | 1 |
| 7 | Analysis of volatile organic compounds in mainstream cigarette smoke显示文摘 | Polzin G M Kosa-Maines R E Ashley D L | 2007 | Environmental Science & Technology2007，41，4： | 1 |
| 8 | Outpatient management of patients with low-risk upper-gastrointestinal haemorrhage: multicentre validation and prospective evaluation显示文摘 | AJ Stanley D Ashley HR Dalton C Mowat DR Gaya E Thompson U Warshow M Groome A Cahill G Benson O Blatchford W Murray | 2009 | The Lancet2009，，9657： | 1 |
| 9 | Bone marrow-generated den dritic cells pulsed with tumor extracts or tunor RNA induce antitumor immunity against central nervous system tumors显示文摘 | Ashley D M Faiola B Nair S | 1997 | J Exp Med1997，186，7： | 1 |
| 10 | Using the blood concentration of 2, 5 - dimethylfuran as a marker for smoking显示文摘 | Ashley D L Bonin M A Hamar B | 1996 | International Archives of occupational and Environmental Health1996，68，3： | 1 |
| 11 | Exposure to methyl tertiary butyl ether from oxygenated gasoline in Stamford,Connecticut显示文摘 | Johnson C A Ashley D L Buchta T M Pelletier D J | 1995 | Arch Environ Health1995，50，： | 1 |
| 12 | Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stern-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial显示文摘 | Gajjar A Chintagurnpala M Ashley D | 2006 | Lancet Oncol2006，7，10： | 1 |
| 13 | Rates and patterns of Late Cenozoic denudation in the northernmost Atlantic Coastal Plain and Piedmont显示文摘 | STANFORD S D ASHLEY G M RUSSELL E W B | 2002 | Geological Society of American Bulletin2002，114，： | 1 |
| 14 | A Gis-supported model for the simulation of the spatial structure of wild land fire,Cass Basin显示文摘 | George L M Perry Ashley D Sparrow Lan F Owens | 1999 | Journal of Applied Ecology1999，，36： | 1 |
| 15 | Environmental mobility of antimony around mesothermal stibnite deposits, New South Wales, Australia and southern New Zealand 显示文摘 | Ashley P M Craw D Graham B P | 2003 | Journal of Geochemical Exploration2003，77，1： | 1 |
| 16 | Rheological measurements of the yield strength of combined sediment deposits显示文摘 | WOTHERSPOON D J ASHLEY R M | 1992 | Water Science & Technology1992，25，8： | 1 |
| 17 | Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction显示文摘 | Chen M M Ashley E A Deng D X | 2003 | Circulation2003，108，12： | 1 |
| 18 | In vivo and in vitro characterization of a novel neuroprotective strategy for stroke: isehemie postconditioning显示文摘 | Pignataro G Meller R Inoue K Ordonez A N Ashley M D Xiong Z | 2008 | J Cereb Blood Flow Metab2008，28，： | 1 |
| 19 | Microsatellite analysis of seed dis-persal and parentage of saplings in bur oak,Quercus macro-carpa显示文摘 | Dow B D Ashley M V | 1996 | Molecular Ecology1996，5，： | 1 |
| 20 | Bone marrow-generated dendritic cells pulsed ith tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors显示文摘 | Ashley D M Faiola B Nair S | 1997 | J Exp Med1997，186，7： | 1 |
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