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| 1 | Targeting matrix metalloproteinases in cancer:Bringing new life to old ideas显示文摘Since the identification of matrix metalloproteinases(MMPs),a family of zincdependent endopeptidases,as being a driving factor for cancer progression and patient prognosis,MMPs have been studied extensively.Although early programs targeting MMPs were largely unsuccessful in clinical trials,they remain a viable and highly desirable therapeutic target based on preclinical studies and their role in disease progression.As information regarding the structure and function of these proteinases is compiled and biotechnology evolves,tools to develop better inhibitors are within our grasp.Improved methods for high throughput screening and in silico drug design programs have identified compounds which are highly potent,have high binding affinities,and exhibit favorable pharmacokinetic profiles.More recently,advances in drug delivery methods or compounds which bind outside the active site have brought new light to the field.In this review,we highlight the role of MMPs in cancer,clinical trials for MMP inhibitors,and novel approaches to targeting MMPs in cancer. | Jillian Cathcart Ashleigh Pulkoski-Gross Jian Cao | 2015 | Genes & Diseases2015，2，1： | 18 |
| 2 | 美国医务人员目击工作场所暴力现状调查显示文摘目的:了解美国医疗机构医务人员身体暴力、言语暴力和种族歧视3类暴力事件的目击现状。方法:依据国际劳工组织、国际护士学会、世界卫生组织和国际公共服务组织编制的卫生领域暴力调查问卷制作调查工具,开展网上调查。结果:过去12个月美国医务人员身体暴力、言语暴力以及种族歧视事件的目击率分别是71.9%、84.1%和45.0%。护士3类暴力事件的目击率高于其他医务人员(P<0.05),急诊科、精神科、外科医务人员身体暴力和种族歧视的目击率较高(P<0.05),女性言语暴力的目击率高于男性(P<0.05),目击过暴力事件的医务人员对暴力现状更为担心(P<0.01)。结论:美国医务人员暴力事件目击率较高;护士对暴力事件和女性对言语暴力事件的目击率均较高;身体暴力和种族歧视事件的目击率存在科室差异;目击暴力事件会对医务人员心理造成负面影响。 | Oguagha Ashleigh C. 杨秋霞 陈晶 | 2018 | 医学与社会2018，31，3： | 13 |
| 3 | Clear lens extraction in angle-closure glaucoma patients显示文摘AIM: To describe the results of 5 consecutive cases of clear lens extraction in angle closure patients for the treatment of elevated intraocular pressure (IOP). ·METHODS: Retrospective observational case series. All angle closure patients were on two or more topical glaucoma medications and had prior laser iridotomy. Eyes underwent clear lens extraction by phacoemu - lsification with intraocular lens implantation. ·RESULTS: All five patients in this case series carried the diagnosis of angle -closure glaucoma and had uncontrolled IOP prior to surgery despite topical medications. After clear lens extraction three of the cases had good IOP control (IOP <22mmHg) without the need for topical medications. In one case the IOP was better controlled after surgery, however, topical medications were required. The desired IOP was not met in one case despite restarting maximum topical therapy. ·CONCLUSION: This case series suggests that there may be a role for therapeutic clear lens extraction in select cases of angle-closure glaucoma. | Diego T. Q. Barbosa Ashleigh L. Levison Shan C. Lin | 2013 | International Journal of Ophthalmology(English edition)2013，6，3： | 3 |
| 4 | 肿瘤多学科团队实施现状及影响因素研究显示文摘目的了解医务工作者对于肿瘤多学科团队的态度,以及识别促进和阻碍其实施的因素。方法对武汉两家公立医院的各类肿瘤相关医务人员展开问卷调查,并运用描述性统计分析和卡方检验进行数据分析。结果 99%的受访者认为肿瘤多学科团队对病人有帮助,并且可促进医务工作者的工作。在中国的医院中实施和执行肿瘤多学科团队存在的主要阻碍因素为缺少时间(71.0%)、缺乏动机和激励因素(59.9%)和财政支持不足(57.0%);促进其实施的因素为工作人员之间的协调及沟通(68.6%)、领导能力和团队精神(63.8%)、医疗卫生工作者之间的关系(58.5%)。不同医务工作者对于影响因素的态度存在显著性差异。结论肿瘤专科医生对组建多学科团队的必要性高度认可,但有效实施需要针对缺少时间、缺乏动机、缺少财政支持、行政管理因素以及组织政策等方面的问题提出相应的对策,以促进我国肿瘤多学科团队的建设。 | Leidy Stefany Delgado 陶红兵 蔡苗 Ashleigh Chinelo Oguagha | 2017 | 中国医疗管理科学2017，7，3： | 2 |
| 5 | Enteral nutrition in patients with dementia and stroke显示文摘 | Cecilia Freeman Ashleigh Ricevuto Mark H DeLegge | 2010 | Current Opinion in Gastroenterology2010，，2： | 2 |
| 6 | Role of surface functional groups in the adsorption kinetics of water vapor on microporous activated carbons显示文摘 | Ashleigh J F Yaprak U K Mark T | 2007 | Physical Chemistry2007，111，： | 1 |
| 7 | Cooperation and competition in pathogenic bacteria显示文摘 | ASHLEIGH S G STUART A W ANGUS B | 2004 | Letters to Nature2004，430，10： | 1 |
| 8 | New project procurement process 显示文摘 | David C Brown Melanie J Ashleigh Michael J Riley etc | 2001 | Journal of Management in Engineering2001，17，4： | 1 |
| 9 | New Project Procurement Process 显示文摘 | BROWN D C ASHLEIGH J M RILEY M J | 2001 | Journal of Management in Engineering2001，17，4： | 1 |
| 10 | Hysteretic Adsorption and Desorption of Hydrogen by Nanoporous Metal-Organic Frameworks显示文摘 | Xuebo Zhao Bo Xiao Ashleigh J Fletche | 2004 | Science2004，306，： | 1 |
| 11 | CT-guided embolization of an isolated internal iliac artery aneurysm 8 years after AAA repair显示文摘 | Cartwright-Terry M Ashleigh R Martin D | 2006 | J Endovasc Ther2006，13，4： | 1 |
| 12 | A comparison of bolus chasing and static digital subtraction arteriography in peripheral vascular disease显示文摘 | Ashleigh RJ Hufton AP Razzaq R | 2000 | Br J Radiol2000，73，873： | 1 |
| 13 | Understanding embar- rassment among those with autism:breaking down the com- plex emotion of embarrassment among those with autism显示文摘 | Ashleigh Hillier Lesley Allinson | 2002 | Journal of Autism and Developmental Disorders2002，，6： | 1 |
| 14 | Endovaseular aneu- rysm repair with the Talent stent-graft显示文摘 | Cowie AG Ashleigh R J England RE | 2003 | J Vasc Interv Radio12003，14，8： | 1 |
| 15 | Cooperation and competition in pathogenic bacteria 显示文摘 | Ashleigh S G Stuart A W Angus B | 2004 | Letters to Nature2004，430，： | 1 |
| 16 | The Economics of Speed-Assessing the performance of High Speed Rail in Intermodal显示文摘 | Adib Kanafani Rui Wang Ashleigh Griffin | 2012 | Transportation Procedia-Social and Behavioral Sciences2012，，43： | 1 |
| 17 | Loss of WISP-2/CCN5 signaling in human pancreatic cancer: A potential mechanism for epithelial-mesenchymal-transition显示文摘 | Gopal Dhar Smita Mehta Snigdha Banerjee Ashleigh Gardner Bryan M. McCarty Sharad C. Mathur Donald R. Campbell Suman Kambhampati Sushanta K. Banerjee | 2007 | Cancer Letters2007，，1： | 1 |
| 18 | A Comparision of Bolus Chasing and Static Digital Substraction Arteriography in Peripheral Vascular Disease显示文摘 | Ashleigh R J Hufton AP Razzsq R | 2000 | Br J Radial2000，73，872： | 1 |
| 19 | A Randomized Trial to Increase Physical Activity in Breast Cancer Survivors显示文摘 | LAURA Q. ROGERS PATRICIA HOPKINS-PRICE SANDY VICARI RICHARD PAMENTER KERRY S. COURNEYA STEPHEN MARKWELL STEVEN VERHULST KAREN HOELZER CATHERINE NARITOKU LINDA JONES GARY DUNNINGTON VICTOR LANZOTTI JAMES WYNSTRA LISA SHAH BILLIE EDSON ASHLEIGH GRAFF MICHEL | 2009 | Medicine & Science in Sports & Exercise2009，，4： | 1 |
| 20 | Aberrant expression of cortactin in head and neck squamous cell carcinoma cells is associated with enhanced cell proliferation and resistance to the epidermal growth factor receptor inhibitor gefitinib显示文摘 | Paul Timpson Ashleigh S Wilson | 2007 | Cancer Res2007，67，： | 1 |
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