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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Regioselective oxyfunciionalization of unactivated tertiary and secondary carbon-hydrogen bonds of alkylamines by methyl (trifluoromethyl) dioxirane in acid medium 显示文摘 | Asensio G Gonzalez-Nunez ME Bernardini CB | 1993 | JAm Chem Soc1993，115，16： | 1 |
| 3 | Has evolution in- awareness of guidelines for institution of damage control im- proved outcome in the management of the posttraumatic open abdomen 显示文摘 | Asensio JA Petrone P Rolddn G | 2007 | Arch Surg2007，139，2： | 1 |
| 4 | Has evolution in awareness of guidelines for institution of damage control improved outcome in the management of posttraumatic open abdomen显示文摘 | Asensio J A Petrone P Roldan G | | 0，，02： | 1 |
| 5 | Has evolution in awareness of guidelines for institution of damage eontrol improved outeome in the management of the posttrau- matie open abdomen? 显示文摘 | Asensio JA Petrone P Rold6n G | 2004 | Arch Surg2004，139，2： | 1 |
| 6 | Has evolution in awareness of guidelines for institution of damage control improved outcome in the management of posttraumatie open abdomen显示文摘 | Asensio JA Petrone P Roldan G | 2004 | Areh Surg2004，139，2： | 1 |
| 7 | Has evolution in awareness of guidelines for institution of damage control improved outcome in the management of posttraumatic open abdomen显示文摘 | Asensio JA Petrone P Roldan G | 2004 | Arch Surg2004，139，2： | 1 |
| 8 | Operative management and outcomes in 103 AAST-OIS grads IV and V complex hepatic injuries : Trauma surgeons still need to operat but angioembolization helps显示文摘 | Asensio JA Roldan G Petrone P | 2003 | J Trauma2003，54，4： | 1 |
| 9 | Has evolution in awareness of guidelines for institution of damage control improved outcome in the management of posttraumatic open abdomen显示文摘 | Asensio JA Petrone P Roldan G | 2004 | Arch Surg2004，139，2： | 1 |
| 10 | Has evolution in awareness of guidelines for institution of damage control improved outcome in the management of the posttraumatic open abdomen显示文摘 | Asensio JA Petrone P Roldan G | 2004 | Arch Surg2004，139，2： | 1 |
| 11 | Has evolution in awareness of guidelines for institution of damage control improved outcome in the management of the posttraumatic open abdomen显示文摘 | Petrone P Roldan G | 2004 | Arch Surg2004，139，2： | 1 |
| 12 | Complex problems in penetrating neck trauma显示文摘 | Demetriades D Asensio JA Velmahos G | 1996 | Surg Clin North Am1996，76，4： | 1 |
| 13 | Monoalkylatione of primary aromatic amine via N-(alkoxymethyl) arylamine显示文摘 | Barluenga J Bayon A M Asensio G | 1983 | J Chem Soc Chem Commun1983，19，： | 1 |
| 14 | Hasevolution in awareness of guidelines for instiution of damage control improved outconle in the management of post traumatic open abdoment 显示文摘 | Asensio JA Petrone P Roldan G | 2004 | Arch Surg2004，13，9： | 1 |
| 15 | Steam-activated carbons from a bituminous coal in a continuous multistage fluidized bed pilot plant显示文摘 | MartiN G I Asensio M Font R | 1996 | Carbon1996，34，12： | 1 |
| 16 | Panereatie and duodenal in-juries complex and lethal显示文摘 | Asensio JA Petrone P Roldan G | 2002 | Scand J Surg2002，91，1： | 1 |
| 17 | Has evolution in awareness of guidelines for institution of damage control improved outcome inthe management of posttraumatic open abdomen显示文摘 | Asensio JA Petrone P Roldan G | 2004 | Arch Surg2004，139，2： | 1 |
| 18 | Has evolution in awareness of guidelines for institution of damage control improved outcome in the management of posttraumatic open abdomen 显示文摘 | Asensio JA Petrone P Roldan G | 2004 | Arch Surg2004，139，2： | 1 |
| 19 | Pancreatico-duodenectouny: a rare procedure for the management of complex pancreaticoduodenal injuries 显示文摘 | Asensio J A Petrone P Roldan G | 2003 | J Am Coll Surg2003，197，6： | 1 |
| 20 | Has evolution in awareness of guidelines for institution of damage control improved outcome in the management of posttraumatic open abdomen 显示文摘 | Asensio JA Petrone P Roldan G | 2004 | Arch Surg2004，139，2： | 1 |
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