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| 1 | Diabetes and cancer:Looking at the multiligand/RAGE axis显示文摘The association between diabetes and hyperglycemia and the associated increased risk of several solid and hematologic malignancies has been the subject of investigation for many years.Although the association is not fully understood,current knowledge clearly indicates that diabetes may influence malignant cell transformation by several mechanisms,including hyperinsulinemia,hyperglycemia and chronic inflammation.In this context,the receptor for advanced glycation end-products (RAGE) has emerged as a focal point in its contribution to malignant transformation and tumor growth.We high-light how RAGE,once activated,as it manifests itself in conditions such as diabetes or hyperglycemia,is able to continuously bring about an inflammatory milieu,thus supporting the contribution of chronic inflammation to the development of malignancies. | Armando Rojas Ileana González Erik Morales Ramón Pérez-Castro Jacqueline Romero Héctor Figueroa | 2011 | World Journal of Diabetes2011，2，7： | 11 |
| 2 | Helicobacter Pylori Infection and Lung Cancer: New Insights and Future Challenges显示文摘Helicobacter pylori(H. pylori) is the causative agent of chronic gastritis and peptic ulcer diseases and is an important risk factor for the development functional dyspepsia, peptic ulceration, gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. H. pylori has very high rates of infection in human populations, and it is estimated that over 50% of the world population is infected. Recently, certain extra-gastric manifestations, linked to H. pylori infection, have been widely investigated. Noteworthy, a growing body of evidences supports an association between H. pylori infection with lung cancer. The present review intend to highlight not only the most recent evidences supporting this association, but also some missed points, which must be considered to validate this emerging association. | Ileana GONZALEZ Paulina ARAYA Armando ROJAS | 2018 | 中国肺癌杂志2018，21，9： | 7 |
| 3 | Receptor for advanced glycation end-products axis and coronavirus disease 2019 in inflammatory bowel diseases:A dangerous liaison?显示文摘Compelling evidence supports the crucial role of the receptor for advanced glycation end-products(RAGE)axis activation in many clinical entities.Since the beginning of the coronavirus disease 2019 pandemic,there is an increasing concern about the risk and handling of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in inflammatory gastrointestinal disorders,such as inflammatory bowel diseases(IBD).However,clinical data raised during pandemic suggests that IBD patients do not have an increased risk of contracting SARS-CoV-2 infection or develop a more severe course of infection.In the present review,we intend to highlight how two potentially important contributors to the inflammatory response to SARS-CoV-2 infection in IBD patients,the RAGE axis activation as well as the cross-talk with the renin-angiotensin system,are dampened by the high expression of soluble forms of both RAGE and the angiotensin-converting enzyme(ACE)2.The soluble form of RAGE functions as a decoy for its ligands,and soluble ACE2 seems to be an additionally attenuating contributor to RAGE axis activation,particularly by avoiding the transactivation of the RAGE axis that can be produced by the virus-mediated imbalance of the ACE/angiotensin II/angiotensin II receptor type 1 pathway. | Armando Rojas Ivan Schneider Cristian Lindner Ileana Gonzalez Miguel Angel Morales | 2021 | World Journal of Gastroenterology2021，27，19： | 4 |
| 4 | Oxidative stress in tumor microenvironment--Its role in angiogenesis显示文摘The tumor angiogenesis process is believed to be dependent on an 'angiogenic switch' formed by a cascade of biologic events as a consequence of the 'cross-talk' between tumor cells and several components of local microenvironment including endothelial cells, macrophages, mast cells and stromal components. Oxidative stress represents an important stimulus that widely contributes to this angiogenic switch, which is particularly relevant in lungs, where oxidative stress is originated from different sources including the incomplete reduction of oxygen during respiration, exposure to hypoxia/reoxygenation, stimulated resident or chemoattracted immune cells to lung tissues, as well as by a variety of chemicals compounds. In the present review we highlight the role of oxidative stress in tumor angiogenesis as a key signal linked to other relevant actors in this complex process. | Armando ROJAS Raul SILVA Hectcr FIGUEROA Miguel A MORAINES | 2008 | 中国肺癌杂志2008，11，3： | 2 |
| 5 | Unexpected inverse correlation between Native American ancestry and Asian American variants of HPV16 in admixed Colombian cervical cancer cases显示文摘 | Esteban A. Lopera Armando Baena Victor Florez Jehidys Montiel Constanza Duque Tatiana Ramirez Mauricio Borrero Carlos M. Cordoba Fredy Rojas Rene Pareja Astrid Bedoya Gabriel Bedoya Gloria I. Sanchez | 2014 | Infection, Genetics and Evolution2014，，： | 1 |
| 6 | RAGE at Tumor Microenvironment. Looking at Tumor-associated Macrophages显示文摘A compelling body of evidence has demonstrated that activation of the receptor for advanced glycation endproducts(RAGE)is responsible for triggering an inflammatory response and being associated with many clinical entities,including diabetes,neurodegerative diseases,cardiovascular diseases and cancer^([1-4]). | Fernando DELGADO-LOPEZ Armando ROJAS | 2015 | 中国肺癌杂志2015，18，12： | 1 |
| 7 | A New Potential Attractant for Anastrepha obliqua from Spondias mombin Fruits显示文摘 | Leopoldo Cruz-López Edi A. Malo Jorge Toledo Armando Virgen Alejandro Mazo Julio C. Rojas | 2006 | Journal of Chemical Ecology2006，，2： | 1 |
| 8 | Diabetes mellitus contribution to the remodeling of the tumor microenvironment in gastric cancer显示文摘Compelling pieces of evidence derived from both clinical and experimental research has demonstrated the crucial contribution of diabetes mellitus(DM)as a risk factor associated with increased cancer incidence and mortality in many human neoplasms,including gastric cancer(GC).DM is considered a systemic inflammatory disease and therefore,this inflammatory status may have profound effects on the tumor microenvironment(TME),particularly by driving many molecular mechanisms to generate a more aggressive TME.DM is an active driver in the modification of the behavior of many cell components of the TME as well as altering the mechanical properties of the extracellular matrix(ECM),leading to an increased ECM stiffening.Additionally,DM can alter many cellular signaling mechanisms and thus favoring tumor growth,invasion,and metastatic potential,as well as key elements in regulating cellular functions and cross-talks,such as the microRNAs network,the production,and cargo of exosomes,the metabolism of cell stroma and resistance to hypoxia.In the present review,we intend to highlight the mechanistic contributions of DM to the remodeling of TME in GC. | Armando Rojas Cristian Lindner Iván Schneider Ileana Gonzàlez Hernan Araya Erik Morales Milibeth Gómez Nelson Urdaneta Paulina Araya Miguel Angel Morales | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 1 |
| 9 | Advanced glycation and endothelial functions: A link towards vascular complications in diabetes 显示文摘 | Armando Rojas Miguel A Morales | 2004 | Life Sciences2004，12，： | 1 |
| 10 | Evidence of involvement of the receptor for advanced glycation end-products (RAGE) in the adhesion of Helicobacter pylori to gastric epithelial cells显示文摘 | Armando Rojas Ileana González Boris Rodríguez Jacqueline Romero Héctor Figueroa Jorge Llanos Erik Morales Ramón Pérez-Castro | 2011 | Microbes and Infection2011，，10： | 1 |
| 11 | Contributions of the receptor for advanced glycation end products axis activation in gastric cancer显示文摘Compelling shreds of evidence derived from both clinical and experimental research have demonstrated the crucial contribution of receptor for advanced glycation end products(RAGE)axis activation in the development of neoplasms,including gastric cancer(GC).This new actor in tumor biology plays an important role in the onset of a crucial and long-lasting inflammatory milieu,not only by supporting phenotypic changes favoring growth and dissemination of tumor cells,but also by functioning as a pattern-recognition receptor in the inflammatory response to Helicobacter pylori infection.In the present review,we aim to highlight how the overexpression and activation of the RAGE axis contributes to the proliferation and survival of GC cells as and their acquisition of more invasive phenotypes that promote dissemination and metastasis.Finally,the contribution of some single nucleotide polymorphisms in the RAGE gene as susceptibility or poor prognosis factors is also discussed. | Armando Rojas Cristian Lindner Iván Schneider Ileana González Miguel Angel Morales | 2023 | World Journal of Gastroenterology2023，29，6： | 1 |
| 12 | RAGE in Cancer Lung: the End of a Long and Winding Road is in Sight显示文摘Introduction The receptor of advanced glycation end-products (RAGE),is a type I single-pass transmembrane protein, member of the multi-ligand immunoglobulin superfamily molecule, which was discovered in 1992, on account of its ability to bind the advanced glycation end-products (AGEs)^([1]). | Armando ROJAS Ileana GONZALEZ Paulina ARAYA | 2018 | 中国肺癌杂志2018，21，9： | 0 |
| 13 | Cell line cross-contamination in biomedical research: a call to prevent unawareness显示文摘在 1950 年代期间,房间线跨污染在生物医学的研究的质量上与严肃的后果作为一个问题出现了。不幸地,这种状况在年变得更坏。在这上下文,一些行动应该着急地被承担由于跨 contaminated 房间线的逐渐地并且有时忽视的使用避免似是而非的数据的产生。关于这个问题不知道海角然后可以把许多科学家变成牺牲品或甚至这种讨厌的状况的罪犯。包含研究人员,房间银行,杂志,和资助机构的合作行动被需要节省科学名声以及被用来生产似是而非的数据的许多公共或私人的资源。 | Armando ROJAS Ileana GONZALEZ Hector FIGUEROA | 2008 | Acta Pharmacologica Sinica2008，29，7： | 0 |
| 14 | Advanced-glycation end-products axis:A contributor to the risk of severe illness from COVID-19 in diabetes patients显示文摘Compelling pieces of evidence derived from both clinical and experimental research has demonstrated the crucial role of the receptor for advanced-glycation end-products(RAGE)in orchestrating a plethora of proinflammatory cellular responses leading to many of the complications and end-organ damages reported in patients with diabetes mellitus(DM).During the coronavirus disease 2019(COVID-19)pandemic,many clinical reports have pointed out that DM increases the risk of COVID-19 complications,hospitalization requirements,as well as the overall severe acute respiratory syndrome coronavirus 2 case-fatality rate.In the present review,we intend to focus on how the basal activation state of the RAGE axis in common preexisting conditions in DM patients such as endothelial dysfunction and hyperglycemia-related prothrombotic phenotype,as well as the contribution of RAGE signaling in lung inflammation,may then lead to the increased mortality risk of COVID-19 in these patients.Additionally,the crosstalk between the RAGE axis with either another severe acute respiratory syndrome coronavirus 2 receptor molecule different of angiotensin-converting enzyme 2 or the renin-angiotensin system imbalance produced by viral infection,as well as the role of this multi-ligand receptor on the obesity-associated lowgrade inflammation in the higher risk for severe illness reported in diabetes patients with COVID-19,are also discussed. | Armando Rojas Cristian Lindner Ileana Gonzàlez Miguel Angel Morales | 2021 | World Journal of Diabetes2021，12，5： | 0 |
| 15 | Receptor of advanced glycation end-products axis and gallbladder cancer:A forgotten connection that we should reconsider显示文摘Compelling evidence derived from clinical and experimental research has demonstrated the crucial contribution of chronic inflammation in the development of neoplasms,including gallbladder cancer.In this regard,data derived from clinical and experimental studies have demonstrated that the receptor of advanced glycation end-products(RAGE)/AGEs axis plays an important role in the onset of a crucial and long-lasting inflammatory milieu,thus supporting tumor growth and development.AGEs are formed in biological systems or foods,and food-derived AGEs,also known as dietary AGEs are known to contribute to the systemic pool of AGEs.Once they bind to RAGE,the activation of multiple and crucial signaling pathways are triggered,thus favoring the secretion of several proinflammatory cytokines also involved in the promotion of gallbladder cancer invasion and migration.In the present review,we aimed to highlight the relevance of the association between high dietary AGEs intakes and high risk for gallbladder cancer,and emerging data supporting that dietary intervention to reduce gallbladder cancer risk is a very attractive approach that deserves much more research efforts. | Armando Rojas Cristian Lindner Iván Schneider Ileana Gonzàlez Miguel Angel Morales | 2022 | World Journal of Gastroenterology2022，28，39： | 0 |
| 16 | Emerging and multifaceted potential contributions of polyphenols in the management of type 2 diabetes mellitus显示文摘Type 2 diabetes mellitus(T2DM)is recognized as a serious public health concern with a considerable impact on human life,long-term health expenditures,and substantial health losses.In this context,the use of dietary polyphenols to prevent and manage T2DM is widely documented.These dietary compounds exert their beneficial effects through several actions,including the protection of pancreatic islet β-cell,the antioxidant capacities of these molecules,their effects on insulin secretion and actions,the regulation of intestinal microbiota,and their contribution to ameliorate diabetic complications,particularly those of vascular origin.In the present review,we intend to highlight these multifaceted actions and the molecular mechanisms by which these plant-derived secondary metabolites exert their beneficial effects on type 2 diabetes patients. | Ileana González Cristian Lindner Ivan Schneider Erik Diaz Miguel Angel Morales Armando Rojas | 2024 | World Journal of Diabetes2024，15，2： | 0 |
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