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| 1 | Prognosis of lymphotropic invasive micropapillary breast carcinoma analyzed by using data from the National Cancer Database显示文摘Background:Invasive micropapillary carcinoma(IMPC)is an uncommon subtype of breast cancer.Previous studies of this subtype demonstrated a higher propensity for lymph node metastases as compared with invasive ductal carci-noma(IDC).The purpose of the present study was to determine the clinical characteristics,outcomes,and propensity for lymph node metastasis of patients with IMPC of the breast recorded in the National Cancer Database(NCDB).Methods:Records of patients with IMPC diagnosed between 2004 and 2014 were retrieved from the NCDB.Log-rank test was performed to evaluate associations of clinical characteristics with overall survival(OS).Cox proportional hazards model was used to determine variables associated with OS.Results:Overall,2660 patients with IMPC met the selection criteria;the 5-year OS rate was 87.5%and 24.9%of patients had nodal involvement at presentation.Patients with≥4 positive lymph nodes had shorter OS than node-negative patients,whereas patients with 1-3 positive nodes had similar OS to node-negative patients.Age<65 years,receipt of radiotherapy,and estrogen receptor positivity were also associated with prolonged OS.The benefit of radiotherapy was limited to IMPC patients undergoing lumpectomy;there was no benefit for the patients undergoing mastectomy(regardless of nodal positivity/negativity).Conclusions:Favorable prognostic factors of IMPC patients included age<65 years,<4 positive lymph nodes,receipt of radiotherapy,and estrogen receptor positivity.The results presented herein suggest a survival benefit asso-ciated with radiotherapy in IMPC treatment,though this may be limited to the patients treated with lumpectomy. | Gary D.Lewis Yan Xing Waqar Haque Tejal Patel Mary Schwartz Albert Chen Andrew Farach Sandra S.Hatch E.Brian Butler Jenny Chang Bin S.Teh | 2019 | Cancer Communications2019，39，1： | 7 |
| 2 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 3 | Hyperthermic intraperitoneal doxorubicin: pharmacokinetics, metabolism, and tissue distribution in a rat model显示文摘 | Pierre Jacquet Andrew Averbach O. Anthony Stuart David Chang Paul H. Sugarbaker | 1997 | Cancer Chemotherapy and Pharmacology1997，，2： | 4 |
| 4 | Bigtable显示文摘 | Fay Chang Jeffrey Dean Sanjay Ghemawat Wilson C. Hsieh Deborah A. Wallach Mike Burrows Tushar Chandra Andrew Fikes Robert E. Gruber | 2008 | ACM Transactions on Computer Systems (TOCS)2008，，2： | 3 |
| 5 | 采用美国国家癌症数据库数据分析淋巴浸润性微乳头状乳腺癌的预后显示文摘背景与目的浸润性微乳头状癌(invasive micropapillary carcinoma,IMPC)是乳腺癌中一种罕见的亚型。已有研究表明,与浸润性导管癌(invasive ductal carcinoma,IDC)相比,该亚型更易发生淋巴结转移。本研究旨在明确美国国家癌症数据库(National Cancer Database,NCDB)中记录的乳腺IMPC患者的临床特征、结局和淋巴结转移倾向性。方法从NCDB中检索2004–2014年之间诊断为IMPC患者的病历,并对其进行log-rank检验以评估临床特征与总生存期(overall survival,OS)的相关性。采用Cox比例风险模型确定OS相关因素。结果本研究共纳入2660例IMPC患者。5年OS率为87.5%,24.9%患者出现淋巴结转移。阳性淋巴结数≥4的患者的OS短于阴性淋巴结的患者,而阳性淋巴结数为1–3的患者的OS与阴性淋巴结患者相似。年龄<65岁、接受放疗和雌激素受体阳性也与OS延长有关。放疗仅对接受肿块切除术的IMPC患者有效,对进行乳房切除术的患者无效(无论淋巴结阳性/阴性)。结论IMPC患者的有利预后因素包括年龄<65岁、阳性淋巴结数<4、接受放疗和雌激素受体阳性。本研究结果表明,IMPC患者的生存获益与放疗相关,但可能仅限于经肿块切除术治疗的患者。 | Gary DLewis Yan Xing Waqar Haque Tejal Patel Mary Schwartz Albert Chen Andrew Farach Sandra SHatch EBrian Butler Jenny Chang Bin S.Teh | 2020 | 癌症2020，39，2： | 2 |
| 6 | Understanding pancreatic cancer genomes显示文摘 | Mark J. Cowley David K. Chang Marina Pajic Amber L. Johns Nicola Waddell Sean M. Grimmond Andrew V. Biankin | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，，6： | 2 |
| 7 | Personalising pancreas cancer treatment:When tissue is the issue显示文摘The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved outcomes.Advances in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease course.This has allowed identification of potentially actionable mutations that may be targeted by new biological agents.The heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the condition.This paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice. | Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor Chris Hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
| 8 | Imagine:Media Processing with Streams显示文摘 | William J Dally Ujval J Kapasi Peter Mattson Jinyung Namkoong John D Owens Brian Towles Andrew Chang | 2001 | IEEE Micro (S0272-1732)2001，，： | 1 |
| 9 | Assessing long-term environmental risks of trace elements in phosphate fertilizers显示文摘 | Weiping Chen Andrew C. Chang Laosheng Wu | 2007 | Ecotoxicology and Environmental Safety2007，，1： | 1 |
| 10 | 查看详情显示文摘 | Hyo Jun Kim Dong Hwan Kim Andrew SKim Sang Myun Kim Chang Seop Koh Gyu-Hong Kang | | 0，，： | 1 |
| 11 | Anterior maxillary advancement using tooth supported distraction osteogenesis 显示文摘 | Block MS Deneen Cervini Andrew Chang | 1995 | J Oral Maxillofac Surg1995，53，： | 1 |
| 12 | Synthesis of soluble metallophthalocyanines from a metal-free phthalocyanine by microwave irradiation显示文摘 | Lung Chang Liu Chung Chun Lee Andrew Teh Hu | 2001 | Journal of Porphyrins and Phthalocyanines2001，5，11： | 1 |
| 13 | In situ optical variability and relationships in the Santa Barbara Channel: implications for remote sensing显示文摘 | CHANG G C BARNARD Andrew H MCLEAN Scott EGLI Peter J | 2006 | Applied Optics2006，45，15： | 1 |
| 14 | The JCAHO patient safety event taxono- my: a standardized terminology and classifica- tion schema for near misses and adverse events 显示文摘 | Andrew Chang Paul M Schyve | 2005 | International Journal for Quality in Health Care2005，17，2： | 1 |
| 15 | Design and fabrication of silicon-tessellated structures for monocentric imagers显示文摘Compared with conventional planar optical image sensors,a curved focal plane array can simplify the lens design and improve the field of view.In this paper,we introduce the design and implementation of a segmented,hemispherical,CMOS-compatible silicon image plane for a 10-mm diameter spherical monocentric lens.To conform to the hemispherical focal plane of the lens,we use flexible gores that consist of arrays of spring-connected silicon hexagons.Mechanical functionality is demonstrated by assembling the 20-μm-thick silicon gores into a hemispherical test fixture.We have also fabricated and tested a photodiode array on a siliconon-insulator substrate for use with the curved imager.Optical testing shows that the fabricated photodiodes achieve good performance;the hemispherical imager enables a compact 160°field of view camera with >80% fill factor using a single spherical lens. | Tao Wu Stephen S.Hamann Andrew C.Ceballos Chu-En Chang Olav Solgaard Roger T.Howe | 2016 | Microsystems & Nanoengineering2016，2，1： | 1 |
| 16 | Reasons for cost and schedule increase for engineering design projects 显示文摘 | Andrew Shing-Tao Chang | 2003 | Journal of Managernent in Engineering2003，18，1： | 1 |
| 17 | Environmental risks of trace elements associated with long-term phosphate fertilizers applications: A review显示文摘 | Wentao Jiao Weiping Chen Andrew C. Chang Albert L. Page | 2012 | Environmental Pollution2012，，： | 1 |
| 18 | Multi-factors influencing the spatial distribution of polycyclic aromatic hydrocarbons in soils surrounding drinking water protection zone显示文摘We selected the Guanting Reservoir in Beijing, China as a case where an industrial area locates on the upwind corner to study the influence of human activities and natural processes on the distribution of polycyclic aromatic hydrocarbons (PAHs) in soils. Soil PAH concentrations in the study area follow a log-normal probability distribution function, suggesting that distribution of PAH in soils was affected by human activities. Distribution of PAHs in soils was significantly affected by the point source that high PAH concentrations were observed in near industrial area with an obvious declining trend from the northwest to the southeast which was the prevailing wind direction in this area. Away from the influence of point source, distribution of PAHs in soils was found to significantly correlate with total organic carbon content, while the influences of agricultural land uses and type of soil texture on the total soil PAHs contents and ring compositions were quite limited. The results can provide some evidences and data on the pollutant accumulation in drink water protection area influenced by natural processes and human activities. | Wentao Jiao Tieyu Wang Yonglong Lu Andrew Chang Weiping Chen | 2013 | Journal of Environmental Sciences2013，25，8： | 1 |
| 19 | 乳腺癌基因治疗现状及进展显示文摘乳腺癌已经超越宫颈癌成为居于发展中国家女性肿瘤死亡率首位的恶性肿瘤,其发病率约占全身恶性肿瘤的23%,死亡率占14%.目前乳腺癌的治疗方法主要包括手术、放疗、化疗或联合治疗,但治疗效果有限,尤其是对三阴乳腺癌及晚期乳腺癌效果不佳,探索新的治疗方法刻不容缓.随着精准医疗概念的提出,乳腺癌的发生、转移、耐药机制、基因组学等分子水平的研究逐渐深入,推动了乳腺癌基因治疗地快速发展.目前,乳腺癌基因治疗主要包括癌基因治疗、抑癌基因治疗、免疫基因治疗、多药耐药基因治疗、自杀基因治疗、溶瘤病毒治疗、microRNA治疗等,本文将从上述治疗及进展方面进行综述. | 周晔 邓新娜 范晓燕 李阳 张丽霞 Andrew Chang 李庆霞 | 2017 | 转化医学电子杂志2017，4，9： | 1 |
| 20 | Arsenic promotes angiogenesis in vitro via a heme oxygenase-1-dependent mechanism显示文摘 | Dan Meng Xin Wang Qingshan Chang Andrew Hitron Zhuo Zhang Mei Xu Gang Chen Jia Luo Binghua Jiang Jing Fang Xianglin Shi | 2010 | Toxicology and Applied Pharmacology2010，，3： | 1 |
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