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您的检索式：作者名="Andrea Manunta"
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| 1 | Can cyclin-dependent kinase 4/6 inhibitors convert inoperable breast cancer relapse to operability? A case report显示文摘BACKGROUND Pathological complete response(pCR) is rare in hormone receptor-positive(HR+)HER2-negative breast cancer(BC) treated with either endocrine therapy(ET) or chemotherapy. Radical resection of locoregional relapse, although potentially curative in some cases, is challenging when the tumor invades critical structures.The oral cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with ET has obtained a significant increase in objective response rates and progression-free survival in patients with advanced BC and is now being evaluated in the neoadjuvant setting. We present a clinical case of a patient with an inoperable locoregional relapse of HR+ HER2-negative BC who experienced p CR after treatment with palbociclib.CASE SUMMARY We report the clinical case of a 60-year-old patient who presented with an inoperable locoregional relapse of HR+, HER2-negative BC 10 years after the diagnosis of the primary tumor. During a routine follow-up visit, breast magnetic resonance imaging and positron emission tomography/computed tomography revealed a 4-cm lesion in the right subclavicular region, infiltrating the chest wall and extending to the subclavian vessels, but without bone or visceral involvement. Treatment was begun with palbociclib plus letrozole, converting the disease to operability over a period of 6 mo. Surgery was performed and a p CR achieved. Of note, during treatment the patient experienced a very uncommon toxicity characterized by burning tongue and glossodynia associated with dysgeusia, paresthesia, dysesthesia, and xerostomia. A reduction in the dose of palbociclib did not provide relief and treatment with the inhibitor was thus discontinued, resolving the tongue symptoms. Laboratory exams were unremarkable. Given that this was a late relapse, the tumor was classified asendocrine-sensitive, a condition associated with high sensitivity to palbociclib.CONCLUSION This case highlights the potential of the cyclin-dependent kinase 4/6 inhibitor plus ET combination to achieve pCR in locoregional relapse of BC, enabling surgical resection of a lesion initially considered inoperable. | Michela Palleschi Roberta Maltoni Eleonora Barzotti Elisabetta Melegari Annalisa Curcio Lorenzo Cecconetto Samanta Sarti Silvia Manunta Andrea Rocca | 2020 | World Journal of Clinical Cases2020，8，3： | 0 |
| 2 | 应用背向散射和二次发射扫描电镜观察未脱钙未染色组织块关节软骨形态:一项描述性研究(英文)显示文摘背景:在与关节软骨有关的组织工程研究中,应用未脱钙和未染色的样本对于保留关节软骨的三维结构十分有利。当分析大量样本时,应用未脱钙的组织块将减少实验时间和复杂性。目的:检验在未脱钙、未染色的组织块上研究关节软骨形态的可能性,这样可以避免切割并染色薄切片。方法:取新西兰白兔和Sardinian绵羊的股骨髁,在多聚甲醛溶液中固定,乙醇中脱水,包埋于多异丁烯酸甲酯中,切成组织块,并染色。将金钯溅镀于标本上,然后用Jeol JSM 6310电子显微镜进行观察。将背向散射和二次发射扫描电镜对组织块相同部位的观察结果进行合并分析。结果与结论:在兔的关节软骨组织块上,可明显区分未钙化与钙化软骨的传代,但较难辨认位于Ⅱ区和Ⅲ区的小软骨陷窝。在绵羊的软骨组织块中,则能较为容易地区分关节软骨各区和细胞结构。应用背向散射电镜能容易分辨出钙化软骨结构和潮标。合并二次发射扫描电镜和背向散射电镜,可在样本上观察到大的腔道。这些腔道穿过软骨下骨和钙化软骨,终止于未钙化的软骨。结果表明,应用背向散射和二次发射扫描电镜能在未脱钙和未染色的包埋组织块上观察到关节软骨的三维结构。 | Antonio Merolli Andrea Manunta Gary Phillips Matteo Santin Francesco Catalano | 2010 | 中国组织工程研究与临床康复2010，14，33： | 0 |
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