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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Electoral Surveys' Influence on the Voting Processes: A Cellular Automata Model显示文摘 | Alves S G Oliveira N M Martins M L | 2002 | Physica A: Statistical Mechanics and Its Applications2002，316，14： | 1 |
| 3 | Urinary 11-dehydro thromboxane B 2 levels in type 2 diabetic patients before and during aspirin intake显示文摘 | Lillian Harboe Gon?alves Luci Maria Sant'Ana Dusse Ana Paula Fernandes Karina Braga Gomes Mirelle Oliveira Sóter Michelle Teodoro Alves Kathryna Fontana Rodrigues Fernanda Rocha Freitas Flavia Komatsuzaki Marinez Oliveira Sousa Adriana Aparecida Bosco Gér | 2011 | Clinica Chimica Acta2011，，15： | 1 |
| 4 | Mining user con- textual preferences 显示文摘 | DE AMO S BUENO M L P ALVES G | 2013 | Journal of InfmTnation & Data Manage- ment2013，4，1： | 1 |
| 5 | Nitriding of titanium disks and industrial dental implants using hollow cathode discharge显示文摘 | Jr ALVES C GUERRA NETO C L B MORAIS G H S | 2006 | Surface and Coatings Technology2006，200，： | 1 |
| 6 | Mental health and physical inactivity during pregnancy:a cross-sectional study nested in the BRISA cohort study 显示文摘 | Takahasi E H Alves M T Alves G S | 2013 | Cad Sande Publica2013，29，8： | 1 |
| 7 | Ultrasonic Evaluation of the Physical and MechanicalProperties of Granites显示文摘 | VASCONCELOS G LOURENCO PB ALVES C A S | 2008 | Ultrasonics2008，48，6： | 1 |
| 8 | Emission quantum yield of europium (Ⅲ) mixed complexes with thenoyhriiluoroacetonate and some aromatic ligands 显示文摘 | Silva F R G E Menezes J F S Rocha G B Rocha G B Alves S Brito H F Longo R L Malta O L | 2000 | Journal of Alloys and Compounds2000，303，304： | 1 |
| 9 | Cream cheese as a symbiotic food carrier using B ifidobacterium animalis B b‐12 and L actobacillus acidophilus L a‐5 and inulin显示文摘 | Larissa L Alves Neila S P S Richards Paula Mattanna Diego F Andrade Adriano P S Rezer Liana I G Milani Adriano G Cruz José A F Faria | 2012 | Int J Dairy Technol2012，，1： | 1 |
| 10 | Early diagnostic and endoscopic dilatation for the treatment of acquired upper airway stenosis after intubation in children显示文摘 | MAKSOUD FILHO J G GONALVES M E CARDOSO S R | 2008 | J Pediatr Surg2008，43，7： | 1 |
| 11 | Well-defined meso- porosity on lignocellulosic-derived activated carbons 显示文摘 | Ana S A Maraisa G Alves T I | 2012 | Carbon2012，50，： | 1 |
| 12 | The influence of the dispersion technique on the characteristics of the W-Cu powders and on the sintering behavior显示文摘 | da ALVES F C da PEREIRA A G S GOMES U U | 2003 | Powder Technology2003，134，12： | 1 |
| 13 | Electoral Surveys’Influence on the Voting Processes:A Cellular Automata Model显示文摘 | Alves S G Oliveira Neto N M Martins M L | 2002 | Physica A:Statistical Mechanics and Its Applications2002，316，14： | 1 |
| 14 | WCOT glass capillary columns in flavour chemistry显示文摘 | Jennings W G Wyllie S G Alves S | 1977 | Chromatographia1977，10，8： | 1 |
| 15 | Electoral surreysJ influ- ence on the voting processes: a cellular automata model显示文摘 | Alves S G Oliveira N M Martins M L | 2002 | PhysicaA2002，32，36： | 1 |
| 16 | Glycerol as a recyclable solvent for copper-catalyzed cross-coupling reactions of diaryl diselenides with aryl boronic acids 显示文摘 | Ricordi V G Freitas C S Alves D | 2012 | Green Chem2012，14，： | 1 |
| 17 | Multivariate analysis to determine the genetic distance among backcross papaya (Carica papaya) progenies显示文摘 | RAMOS H C PEREIRA M G GON(C)ALVES L S | 2012 | Genetics and Molecular Research2012，11，2： | 1 |
| 18 | 显示文摘 | Magnus A Carvalho G Alves C S | 2007 | Journal of Alloys and Compounds2007，432，： | 1 |
| 19 | Temperature effect on the physical-chemical characteristics of aqueous solutions with spray adjuvants 显示文摘 | Cunha J Alves G S Reis E F | 2010 | Planta Daninha2010，28，3： | 1 |
| 20 | Determination of Cd and Pb in Biological Reference Materials by Electrothermal Atomic Absorption Spectrometry:a Comparison of Three Ultrasonic - based Sample Treatment Procedures 显示文摘 | Maduro C Vale G Alves S | 2006 | Talanta2006，68，4： | 1 |
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