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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
| 3 | Measurements of transpiration from savannah shrubs using sap flow gauges显示文摘 | ALLEN S J GRIME V L | 1995 | Agri and For Meter1995，75，： | 2 |
| 4 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 5 | Measurement and estimation of evaporation from soil under sparse barley crops in northem Syria显示文摘 | Allen S J | 1990 | Agric Forest Meteorol1990，49，4： | 1 |
| 6 | Asymptotic profile of thesteady states for an SIS epidemic patch model显示文摘 | Allen L J S Bolker B M Lou Y Nevai A L | 2007 | SIAM J Appl Math2007，，67： | 1 |
| 7 | The localization of target antigens and autoantibodies in linear IgA disease is variable; correlation of immunogold electron microscopy and immunoblotting显示文摘 | Zhou S Ferguson DJ Allen J | 1998 | Br J Dermatol1998，139，： | 1 |
| 8 | Nonlinear shear instabilities of alongshore currents over barred beaches 显示文摘 | Slinn D N Allen J S Newberger P A | 1998 | Journal of Geophysical Research1998，103，18： | 1 |
| 9 | 4 THZ Sidewall-Etched Varactors for Sub-Mm-Wave Sampling Circuits显示文摘 | Allen S T Bhattacharya U Rodwell M J W | 1993 | IEEE1993，，： | 1 |
| 10 | Effect of 2,6 - di- chloroisonicotinic acid or benzothiadiazole on Alternaria leaf spot, bacterial blight and VerticiUium wilt in cotton under field conditions 显示文摘 | Colson - Hanks E S Allen S J Deverall B J | 2000 | Australasian Plant Pathology2000，29，3： | 1 |
| 11 | Deleterious rhizosphere bacteria:An integrating perspectice显示文摘 | Nehl D B Allen S J Brown J F | 1996 | Applied Soil Ecology1996，5，： | 1 |
| 12 | Alteration of stimulus specific guard cell calcium oscillations and stomatal closing in arabidopsis det3 mutant显示文摘 | ALLEN G J CHU S P SCHUMACHER K | 2000 | Science2000，289，： | 1 |
| 13 | Measurements of transpiration from savannah shrubs using sap flow gauges 显示文摘 | Allen S J Grime V L | 1995 | Agri and For Meter1995，75，： | 1 |
| 14 | Diagnostic utility of P161NK4A: a reappraisal of its use in cerbical biopsies显示文摘 | Muluany N J Allen D G Wilson S M | 2008 | Pathology2008，40，4： | 1 |
| 15 | Progress on tooling by 3D printing:Conformal cooling,dimensional control,surface finish and hardness显示文摘 | Sachs E Allen S Guo J E | 1997 | Proc of Solid Freeform Fabrication Symposium1997，，： | 1 |
| 16 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 17 | Asymptotic profile of thesteady states ibr an SI~ epidemic reaction-diffusion model显示文摘 | Allen L J S Bolker B M Lou Y Nevai A L | 2008 | Discr Cont Dyn Sys A2008，，21： | 1 |
| 18 | Effect of reinforcement on the aging response of cast 6061Al-Al2O3 particulate composites显示文摘 | ALLEN S M HAFLEY J L | 1991 | Metall Trans1991，22，1： | 1 |
| 19 | RA: Genotyping TAP2 variants in North American Caucasians, Brazilians and Africans显示文摘 | Tang J Freedman D O Allen S | 2001 | Genes Immunol2001，2，： | 1 |
| 20 | Serum and urine concentrations of trypsinogen-activation peptide as markers for acute pancreatitis in cats显示文摘 | ALLEN H S STEINER J BROUSSARD J | 2006 | Can J Vet Res2006，70，： | 1 |
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