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| 1 | Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin,TGF-β1,IL-13 and oxidative stress显示文摘AIM To evaluate the therapeutic effects of bone marrowderived CD11b+CD14+ monocytes in a murine model of chronic liver damage. METHODS Chronic liver damage was induced in C57BL/6 mice by administration of carbon tetrachloride and ethanol for 6 mo. Bone marrow-derived monocytes isolated by immunomagnetic separation were used for therapy. The cell transplantation effects were evaluated by morphometry,biochemical assessment,immunohistochemistry and enzyme-linked immunosorbent assay. RESULTS CD11b+CD14+ monocyte therapy significantly reduced liver fibrosis and increased hepatic glutathione levels. Levels of pro-inflammatory cytokines,including tumor necrosis factor-α,interleukin(IL)-6 and IL-1β,in addition to pro-fibrotic factors,such as IL-13,transforming growth factor-β1 and tissue inhibitor of metalloproteinase-1 also decreased,while IL-10 and matrix metalloproteinase-9 increased in the monocytetreated group. CD11b+CD14+ monocyte transplantation caused significant changes in the hepatic expression of α-smooth muscle actin and osteopontin. CONCLUSION Monocyte therapy is capable of bringing about improvement of liver fibrosis by reducing oxidative stress and inflammation,as well as increasing antifibrogenic factors. | Veruska Cintia Alexandrino de Souza Thiago Almeida Pereira Valéria Wanderley Teixeira Helotonio Carvalho Maria Carolina Accioly Brelaz de Castro Carolline Guimaraes D’assuncao Andreia Ferreira de Barros Camila Lima Carvalho Virgínia Maria Barros de Lorena Vláudia Maria Assis Costa Alvaro Aguiar Coelho Teixeira Regina Celia Bressan Queiroz Figueiredo Sheilla Andrade de Oliveira | 2017 | World Journal of Gastroenterology2017，23，28： | 6 |
| 2 | Molecular findings in Brazilian patients with osteogenesis imperfecta 显示文摘 | Reis FC Alexandrino F Steiner CE | 2005 | J Appl Genet2005，46，1： | 1 |
| 3 | Stable-isotope-based labe- ling of styrene degrading microorganisms in biofilters 显示文摘 | ALEXANDRINO M KNIEF C LIPSKI A | 2001 | Appl Environ Microbio12001，67，： | 1 |
| 4 | Predicting the potential distribution of the alien invasive American bullfrog(Lithobates catesbeianus)in Brazil显示文摘 | GIOVANELLI J G R HADDAD C F B Alexandrino J | 2008 | Biological Invasions2008，10，： | 1 |
| 5 | The participation of fathers in the breastfeeding process: Experiences, knowledge, behaviors and emotions显示文摘 | Pontes CM Alexandrino AC Osorio MM | | Pediatr Rio J0，84，： | 1 |
| 6 | Molecular genetics of non-syndromic deafness 显示文摘 | Piatto V B Nascimento E C Alexandrino F | 2005 | Rev Bras OtorhinolarYngol (Engl Ed)2005，71，1： | 1 |
| 7 | Molecular genetics of non-syndromic deafness显示文摘 | Piatto VB Nascimento EC Alexandrino F | 2005 | Rev Bras Otorinolaringol(Engl Ed)2005，71，： | 1 |
| 8 | Predicting the potential distribution of the alien invasive American bullfrog (Lithobates catesbeianus)in Brazil显示文摘 | Giovanelli J G Haddad C F B Alexandrino J | 2008 | Biological Invasions2008，10，： | 1 |
| 9 | Lack of effect of colchicines in alcoholic cirrhosis:final results of a double blind randomized trial显示文摘 | CORTEZ-PINTOH ALEXANDRINO P CAMILO ME | 2002 | Eur J Gastroenterol Hepatol2002，14，： | 1 |
| 10 | Molecular genetics of non--syndromic deafness显示文摘 | Piatto VB Nascimento EC Alexandrino F | 2005 | Rev Bras Otorhinolaryngol (Engl Ed)2005，71，： | 1 |
| 11 | Genetic characterization of southwestern European bovine breeds:a historical and biogeographical reassessment with a set of 16 microsatellites显示文摘 | Baja-Pereira A Alexandrino P Bessa I | 2003 | Journal of Heredity2003，94，： | 1 |
| 12 | Molecular genetics of non--syndromic deafness显示文摘 | Piatto VB Nascimento EC Alexandrino F | 2005 | Rev Bras Otorrino- laringol (Engl Ed)2005，71，： | 1 |
| 13 | International Nosocomial Infection Control Consortiu (INICC) report, data summary of 43 countries for 2007-2012. Device-associated module显示文摘 | Víctor Daniel Rosenthal Dennis George Maki Yatin Mehta Hakan Leblebicioglu Ziad Ahmed Memish Haifaa Hassan Al-Mousa Hanan Balkhy Bijie Hu Carlos Alvarez-Moreno Eduardo Alexandrino Medeiros Anucha Apisarnthanarak Lul Raka Luis E. Cuellar Altaf Ahmed Joseph | 2014 | AJIC: American Journal of Infection Control2014，，： | 1 |
| 14 | Poly(phos- phonate)s via Olefln Metathesis: Adjusting Hydrophobicity and Morphology显示文摘 | Steinbach T AlexandrinoE M Wahlen C | 2014 | Macromolecules2014，47，15： | 1 |
| 15 | Genetic diversity of local Eu-ropean beef cattle breeds for conservation purposes显示文摘 | CAON J ALEXANDRINO P BESSA I | 2001 | Genet Sei Evol2001，33，： | 1 |
| 16 | Use of Escherichia coil BOX-PCR fingerprints to identify ources of fecal contamination of water bodies in the State of Sac Paulo,Brazil 显示文摘 | Carlos C Alexandrino F Stoppe NC | 2010 | Journal of Environmental Management2010，97，： | 1 |
| 17 | Predicting the potential distribution of the alien invasive American bullfrog (Lithobates eatesbeianus) in Brazil显示文摘 | Giovanelli J G R Haddad C F B Alexandrino J | 2008 | Biological Invasions2008，10，： | 1 |
| 18 | Newborn hearing screening and genetic testing in 8974 Brazilian neonates显示文摘 | Karin de A.B. Nivoloni Sueli M. da Silva-Costa Mariza C.A. Pomílio Tania Pereira Karen de C. Lopes Vanessa C.S. de Moraes Fabiana Alexandrino Camila A. de Oliveira Edi L. Sartorato | 2010 | International Journal of Pediatric Otorhinolaryngology2010，，8： | 1 |
| 19 | A Comparative Study of Non-Lipid Nanoemulsion of Propofol with Solutol and Propofol Emulsion with Lecithin 显示文摘 | RODRIGUES T A ALEXANDRINO R A KANCZUK M E | 2012 | Revista Brasileira de Anestesiologia2012，62，3： | 1 |
| 20 | 2008 Predicting the potential distribution of the alien invasive A merican bullfrog(Lithobates catesbeianus) in Brazil显示文摘 | Giovanelli J G R Haddad C F B Alexandrino J | 2008 | Bio logical Invasions2008，10，： | 1 |
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