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| 1 | Biliary complications after liver transplantation:current perspectives and future strategies显示文摘Importance:Liver transplantation(LT)is a life-saving therapy for patients with end-stage liver disease and with acute liver failure,and it is associated with excellent outcomes and survival rates at 1 and 5 years.The incidence of biliary complications(BCs)after LT is reported to range from 5%to 20%,most of them occurring in the first three months,although they can occur also several years after transplantation.Objective:The aim of this review is to summarize the available evidences on pathophysiology,risk factors,diagnosis and therapeutic management of BCs after LT.Evidence Review:a literature review was performed of papers on this topic focusing on risk factors,classifications,diagnosis and treatment Findings:Principal risk factors include surgical techniques and donor’s characteristics for biliary leakage and anastomotic biliary strictures and vascular alterations for non-anastomotic biliary strictures.MRCP is the gold standard both for intra-and extrahepatic BCs,while invasive cholangiography should be restricted for therapeutic uses or when MRCP is equivocal.About treatment,endoscopic techniques are the first line of treatment with success rates of 70-100%.The combined success rate of ERCP and PTBD overcome 90%of cases.Biliary leaks often resolve spontaneously,or with the positioning of a stent in ERCP for major bile leaks Conclusions and Relevance:BCs influence morbidity and mortality after LT,therefore further evidences are needed to identify novel possible risk factors,to understand if an immunological status that could lead to their development exists and to compare the effectiveness of innovative surgical and machine perfusion techniques. | Bianca Magro Matteo Tacelli Alessandra Mazzola Filomena Conti Ciro Celsa | 2021 | Hepatobiliary Surgery and Nutrition2021，10，1： | 12 |
| 2 | Autosomal recessive paediatric sick sinus syndrome associated with novel compound mutations in SCN5A显示文摘 | Takahide Kodama Alessandra Serio Marcello Disertori Gabriele Bronzetti Marta Diegoli Nupoor Narula Maurizia Grasso Silvia Mazzola Eloisa Arbustini | 2012 | International Journal of Cardiology2012，，： | 1 |
| 3 | High liver RBP4 protein content is associated with histological features in patients with genotype 1 chronic hepatitis C and with nonalcoholic steatohepatitis显示文摘 | Salvatore Petta Claudio Tripodo Stefania Grimaudo Daniela Cabibi Calogero Cammà Antonietta Di Cristina Vito Di Marco Gaetano Di Vita Sabrina Ingrao Alessandra Mazzola Giulio Marchesini Rosaria Pipitone Antonio Craxì | 2011 | Digestive and Liver Disease2011，，5： | 1 |
| 4 | High liver RBP4 protein content is associated with histological features in patients with genotype 1 chronic hepatitis C and with nonalcoholic steatohepatitis显示文摘 | Salvatore Petta Claudio Tripodo Stefania Grimaudo Daniela Cabibi Calogero Cammà Antonietta Di Cristina Vito Di Marco Gaetano Di Vita Sabrina Ingrao Alessandra Mazzola Giulio Marchesini Rosaria Pipitone Antonio Craxì | 2011 | Digestive and Liver Disease2011，，5： | 1 |
| 5 | COVID-19 in a liver transplant recipient:Could iatrogenic immunosuppression have prevented severe pneumonia?A case report显示文摘BACKGROUND Coronavirus disease(COVID)is a new and highly contagious infectious disease caused by the coronavirus(COVID-19 or severe acute respiratory syndrome coronavirus 2).There is limited data regarding the incidence and management of COVID-19 in immunocompromised patients’post-transplantation.In the pre-COVID-19 era,these patients were already at an increased risk of developing opportunistic infections.These often manifested with atypical symptoms.CASE SUMMARY We report another case of uneventful COVID-19 pneumonia in a 58-year old male who was 18 mo’post liver transplantation.He received tacrolimus monotherapy since July 2019.The clinical manifestations included only epigastric pain radiating to the right hypochondrium,nausea and vomiting.He had no fevers,cough,shortness of breath,anosmia or dysgeusia even if the chest computed tomography scan revealed an extension of the multiple patchy ground-glass density shadows to the upper lobe of the left lung too.He was hospitalised and received a course of oral chloroquine(200 mg×3 per day)for a period of 10 d.Interestingly,the COVID 19 infection was uneventful though there were no modifications to his tacrolimus dosing.He was successfully discharged.We performed subsequent follow-up via telemedicine.CONCLUSION In light of the current pandemic,it is even more important to identify how the liver recipient’s patients present and are managed,especially for immunosuppression treatment. | Anna Sessa Alessandra Mazzola Chetana Lim Mohammed Atif Juliana Pappatella Valerie Pourcher Olivier Scatton Filomena Conti | 2020 | World Journal of Gastroenterology2020，26，44： | 1 |
| 6 | Clinical implications of the hyperdynamic syndrome in cirrhosis显示文摘 | Anna Licata Alessandra Mazzola Daniela Ingrassia Vincenza Calvaruso Calogero Cammà Antonio Craxì | 2014 | European Journal of Internal Medicine2014，，： | 1 |
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