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4篇 您的检索式:作者名="Aleksandra Misicka"
    题名 作者 年代 出处 被引量
1Synthesis and biological properties of gamma-glutamyl-demorphin,a prodrug显示文摘ALEKSANDRA MISICKA IWONA MASZCYNSKA ANDRZEJ WLIPKOWSKI 1996Life Science1996,58,11:1
2Synthesis and biological properties of gamma - glutamyl - dermorphin, a prodrug 显示文摘Aleksandra Misicka Iwona Maszcynska Andrzej W Lipkowski 1996Life Science1996,58,11:1
3Synthesis and biological properties of gammaglutamyl-demorphin,a prodrug显示文摘Aleksandra Misicka Iwona Maszcynska Andrzej W Lipkowski 1996Life Science1996,58,11:1
4Interactions of Mitoxantrone-Modified Superparamagnetic Iron Oxide Nanoparticles with Biomimetic Membranes and Cells显示文摘We report on the formation of conjugates of superparamagnetic iron nanoparticles(NPs)with the chemotherapeutic agent mitroxantrone(MTX).The NPs are synthesized from mixed iron oxides and are ca.15 nm in diameter.Decoration of the NP surface with MTX is accomplished with standard coupling chemistry techniques using sebacic acid as the coupling agent.The resulting NP-MTX conjugate is characterized thermogravimetrically,spectroscopically and electrochemically.The interactions of the NP-MTX conjugate with a model lipid layer formed as a Langmuir-Blodgett(LB)film reveal that the nanoparticle exhibits a significant perturbative effect on the layer,as seen from translational diffusion(FRAP)measurements.Evaluation of the cytotoxicity of the conjugate relative to that of free MTX demonstrates that the NP-MTX conjugate is more toxic than free MTX for both normal and malignant cell lines.These results underscore the importance of targeted delivery in the administration of chemotherapeutic agents.Dorota Nieciecka Krystyna Kijewska Stephen M.Baumler Anna K.Puszko Aleksandra Misicka Gary J.Blanchard Pawel Krysinski 2020材料科学与工程(中英文B版)2020,10,1:0
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