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| 1 | 沥青胶结料低温物理硬化及结晶动力学分析显示文摘为了准确模拟沥青胶结料的物理硬化过程及评估其物理硬化趋势,采用常规弯曲梁流变(BBR)试验设备对10种常用道路沥青进行了改进弯曲梁流变(EBBR)试验,并根据试验结果计算了低温等级损失指标;此外,在设计不同的低温恒温养护时间的基础上,测试了沥青蠕变劲度与蠕变劲度变化率,并采用Avrami等温结晶动力学理论对试验结果进行了拟合分析.结果表明:EBBR法较BBR法对沥青的低温性能区分精度更高;采用Avrami等温结晶动力学理论可较好地模拟沥青胶结料的物理硬化过程,拟合分析得到的Avrami指数与EBBR试验得到的低温等级损失值变化规律具有一致性;沥青胶结料低温物理硬化与结晶性能为评价沥青在实际工程中的低温抗开裂能力提供了更准确的信息. | 聂忆华 孙世恒 丁海波 HESP Adrianus Maria Simon | 2018 | 建筑材料学报2018，21，4： | 5 |
| 2 | Hepatitis B virus subgenotypes and basal core promoter mutations in Indonesia显示文摘AIM:To identify the distribution of hepatitis B virus (HBV) subgenotype and basal core promoter (BCP) mutations among patients with HBV-associated liver disease in Indonesia.METHODS: Patients with chronic hepatitis (CH, n=61), liver cirrhosis (LC, n=62), and hepatocellular carcinoma (HCC,n=48) were included in this study. HBV subgenotype was identified based on S or preS gene sequence, and mutations in the HBx gene including the overlapping BCP region were examined by direct sequencing.RESULTS: HBV genotype B (subgenotypes B2, B3, B4, B5 and B7) the major genotype in the samples, accounted for 75.4%, 71.0% and 75.0% of CH, LC and HCC patients, respectively, while the genotype C (subgenotypes C1, C2 and C3) was detected in 24.6%, 29.0%, and 25.0% of CH, LC, and HCC patients, respectively. Subgenotypes B3 (84.9%) and C1 (82.2%) were the main subgenotype in HBV genotype B and C, respectively. Serotype adw2 (84.9%) and adrq+ (89.4%) were the most prevalent in HBV genotype B and C, respectively. Double mutation (A1762T/G1764A) in the BCP was significantly higher in LC (59.7%) and HCC (54.2%) than in CH (19.7%), suggesting that this mutation was associated with severity of liver disease. The T1753V was also higher in LC (46.8%), but lower in HCC (22.9%) and CH (18.0%), suggesting that this mutation may be an indicator of cirrhosis.CONCLUSION: HBV genotype B/B3 and C/C1 are the major genotypes in Indonesia. Mutations in BCP, such as A1762T/G1764A and T1753V, might have an association with manifestations of liver disease. | Andi Utama Sigit Purwantomo Marlinang Diarta Siburian Rama Dhenni Rino Alvani Gani Irsan Hasan Andri Sanityoso Upik Anderiani Miskad Fardah Akil Irawan Yusuf Wenny Astuti Achwan Soewignjo Soemohardjo Syafruddin AR Lelosutan Ruswhandi Martamala Benyamin Lukito Unggul Budihusodo Laurentius Adrianus Lesmana Ali Sulaiman Susan Tai | 2009 | World Journal of Gastroenterology2009，15，32： | 4 |
| 3 | Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection显示文摘 | Maria Van der Sluis Barbara A.E. De Koning Adrianus C.J.M. De Bruijn Anna Velcich Jules P.P. Meijerink Johannes B. Van Goudoever Hans A. Büller Jan Dekker Isabelle Van Seuningen Ingrid B. Renes Alexandra W.C. Einerhand | 2006 | Gastroenterology2006，，1： | 3 |
| 4 | Association of core promoter mutations of hepatitis B virus and viral load is different in HBeAg(+) and HBeAg(-) patients显示文摘AIM:To identify the prevalence of hepatitis B e antigen (HBeAg) and to assess the association of hepatitis B virus (HBV) core promoter mutations and viral load in Indonesian patients.METHODS:Sixty-four patients with chronic hepatitis,65 with liver cirrhosis and 50 with hepatocellular carcinoma were included in this study.HBeAg and hepatitis B e antibody (HBeAb) tests were performed using enzyme-linked immunosorbent assay and the mutations were analyzed by sequencing.Viral load was measured by real-time polymerase chain reaction.RESULTS:Of 179 patients,108 (60.3%) were HBeAg(-) and 86 (79.6%) of these HBeAg(-) patients had been seroconverted.The A1896 mutation was not found in HBeAg(+) patients,however,this mutation was detected in 70.7% of HBeAg(-) patients.This mutation was frequently found when HBeAg was not expressed (87.7%),compared to that found in HBeAg seroconverted patients (65.1%).The A1899 mutation was also more prevalent in HBeAg(-) than in HBeAg(+) patients (P=0.004).The T1762/A1764 mutation was frequently found in both HBeAg(+) and HBeAg(-) patients,however,the prevalence of this mutation did not significantly differ among the two groups (P=0.054).In HBeAg(+) patients,the T1762/A1764 mutation was correlated with lower HBV DNA (P < 0.001).The A1899 mutation did not correlate with HBV DNA (P=0.609).In HBeAg(-) patients,the T1762/A1764 mutation alone was not correlated with HBV DNA (P=0.095),however,the presence of either the T1762/A1764 or A1896 mutations was associated with increased HBV DNA (P < 0.001).CONCLUSION:The percentage of HBeAg(-) patients is high in Indonesia,and most of the HBeAg(-) patients had been seroconverted.The A1896 mutation was most likely the major cause of HBeAg loss.The T1762/A1764 mutation alone was associated with lower viral loads in HBeAg(+) patients,but not in HBeAg(-) patients. | Andi Utama Marlinang Diarta Siburian Sigit Purwantomo Mariana Destila Bayu Intan Tri Shinta Kurniasih Susan Tai Rino Alvani Gani Laurentius Adrianus Lesmana All Sulaiman Wenny Astuti Achwan Soewignjo Soemohardjo Arnelis Nasrul Zubir Julius Syafruddin AR Lelosutan Benyamin Lukito Tantoro Harmono | 2011 | World Journal of Gastroenterology2011，17，6： | 3 |
| 5 | Hepatitis B virus pre-S2 start codon mutations in Indonesian liver disease patients显示文摘AIM: To identify the prevalence of pre-S2 start codon mutations and to assess their association with liver disease progression. METHODS: The mutations were identified by direct sequencing from 73 asymptomatic carriers, 66 chronic hepatitis (CH), 66 liver cirrhosis (LC) and 63 hepatocellular carcinoma (HCC) patients. Statistical significances were determined using Fisher's exact test, χ 2 test, and t -test analyses whenever appropriate. Pre-S mutation as a risk factor for advanced liver disease was estimated by unconditional logistic regression model adjusted with age, sex, and hepatitis B e antigen (HBeAg). P < 0.05 was considered significant. RESULTS: Mutation of the hepatitis B virus (HBV) pre-S2 start codon was found in 59 samples from 268 subjects (22.0%), with higher prevalence in patients with cirrhosis 27/66 (40.9%) followed by HCC 18/63 (28.6%), chronic hepatitis 12/66 (18.2%) and asymptomatic carriers 2/73 (2.7%) (P < 0.001). Logistic regression analysis showed that pre-S2 start codon mutation was an independent factor for progressive liver disease. Other mutations, at T130, Q132, and A138, were also associated with LC and HCC, although this was not statistically significant when adjusted for age, sex, and HBeAg. The prevalence of pre-S2 start codon mutation was higher in HBV/B than in HBV/C (23.0% vs 19.1%), whilst the prevalence of T130, Q132, and A138 mutation was higher in HBV/C than in HBV/B. The prevalence of pre-S2 start codon mutation was higher in LC (38.9%) and HCC (40.0%) than CH (5.6%) in HBeAg(+) group, but it was similar between CH, LC and HCC in HBeAg(-) group. CONCLUSION: Pre-S2 start codon mutation was higher in Indonesian patients compared to other Asian countries, and its prevalence was associated with advanced liver disease, particularly in HBeAg(+) patients. | Andi Utama Marlinang Diarta Siburian Ismail Fanany Mariana Destila Bayu Intan Rama Dhenni Tri Shinta Kurniasih Syafruddin AR Lelosutan Wenny Astuti Achwan Nasrul Zubir Arnelis Benyamin Lukito Irawan Yusuf Laurentius Adrianus Lesmana Ali Sulaiman | 2012 | World Journal of Gastroenterology2012，18，38： | 3 |
| 6 | Influence of Mechanical Cell Salvage on Red Blood Cell Aggregation, Deformability, and 2,3-Diphosphoglycerate in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass显示文摘 | Y. John Gu Wytze J. Vermeijden Adrianus J. de Vries J. Ans M. Hagenaars Reindert Graaff Willem van Oeveren | 2008 | The Annals of Thoracic Surgery2008，，5： | 2 |
| 7 | Ventilator-induced lung injury and multiple system organ failure;a critical review of facts and hypotheses 显示文摘 | Frans B Arthur S Adrianus J | 2004 | Intensive Care Med2004，30，： | 1 |
| 8 | Relationship between anticoagulant medication and massive intraocular hemorrhage in age-related macular degeneration显示文摘 | M. A. D. Tilanus Willem Vaandrager Marinus H. M. Cuypers Adrianus M. Verbeek Carel B. Hoyng | 2000 | Graefe’s Archive for Clinical and Experimental Ophthalmology2000，，6： | 1 |
| 9 | Grain size dependency in the occurrence of sand waves显示文摘 | Hennie Henri?t Veen Suzanne Jacqueline Marie Hélène Hulscher Michiel Adrianus Frederik Knaapen | 2006 | Ocean Dynamics (-)2006，，3： | 1 |
| 10 | Hepatitis C in the general population of various ethnic origins living in the Netherlands: Should non-Western migrants be screened?显示文摘 | Anouk T. Urbanus Thijs J.W. van de Laar Anneke van den Hoek Freke R. Zuure Adrianus G.C.L. Speksnijder Gijs G.G. Baaten Titia Heijman Henrike J. Vriend Eline L.M. Op de Coul Roel A. Coutinho Maria Prins | 2011 | Journal of Hepatology2011，，6： | 1 |
| 11 | Salmonella “Sops” Up a Preferred Electron Receptor in the Inflamed Intestine显示文摘 | James B. Bliska Adrianus W. M. van der Velden | 2012 | mBio2012，，4： | 1 |
| 12 | Synthesis and biological evaluation of 2,3,5-substituted[1,2,4]thiadiazoles as allosteric modulators of adenosine receptors显示文摘 | Van den Nieuwendijk Adrianus M C H | | 0，，03： | 1 |
| 13 | Electromagnetic radiation from moving, pulsed source distributions: The 3D time-domain relativistic Doppler effect de Hoop显示文摘 | Adrianus T | 2009 | Wave Motion2009，46，1： | 1 |
| 14 | Rationale and design of PRIMA II: A multicenter, randomized clinical trial to study the impact of in-hospital guidance for acute decompensated heart failure treatment by a predefined NT-PRoBNP target on the reduction of readmIssion and Mortality rAtes显示文摘 | Susan Stienen Khibar Salah Andreas H.M. Moons Adrianus L.M. Bakx Petra E. van Pol Jutta M. Schroeder-Tanka Albertus J. Voogel Jan T. Keijer R.A. Mikael Kortz Cathelijne Dickhoff Paola G. Meregalli Jan G. Tijssen Yigal M. Pinto Wouter E. Kok | 2014 | American Heart Journal2014，，： | 1 |
| 15 | Meta- regression analysis of high-frequency ventilation vs conventional ventilation in infant respiratory distress syndrome显示文摘 | CASPER W B CUNO S P M U ADRIANUS J V V | 2007 | Inensive Care Med2007，33，： | 1 |
| 16 | Improved performance and increased applicability of waste stabilization ponds by pretreatment in a UASB reactor显示文摘 | Paula Frassinetti Cavalcanti Catunda Adrianus Cvan Haandel | 1996 | Water Science and Technology1996，33，7： | 1 |
| 17 | Inhibition of nucleoside transport By new analogues of nitrobenzylthioinosine显示文摘 | Paymaneh Y.F Deghati Alice Borghini Adrianus M.C.H van den Nieuwendijk Miriam Dissen-de Groote Adriaan P IJzerman | 2003 | Bioorganic & Medicinal Chemistry2003，，6： | 1 |
| 18 | The effects of operational and environmental variations on anaerobic wastewater treatment systems: A review 显示文摘 | Leitao R C Adrianus C H Zeemen G | 2006 | Bioresource Technology2006，97，： | 1 |
| 19 | Surface Structure of Untreated Parallel and Fishbone Carbon Nanofibres: An Infrared Study显示文摘 | Tijmen GeorgeRos Adrianus Jacobusvan Dillen John WilhelmGeus Diederik ChristiaanKoningsberger | 2002 | ChemPhysChem2002，，2： | 1 |
| 20 | Anaerbic reactor design concepts for domestic wastewater显示文摘 | Adrianus | 2006 | Enviromental Science and Biotechnology2006，5，： | 1 |
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