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| 1 | Trefoil factors in inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD),which comprises ulcerative colitis and Crohn’s disease,is characterized by inflammation of the gastrointestinal tract.The trefoil factors 1,2,and 3(TFF1-3)are a family of peptides that play important roles in the protection and repair of epithelial surfaces,including the gastrointestinal tract.TFFs may be involved in IBD pathogenesis and are a potential treatment option.In the present review,we describe the TFF family and their potential role in IBD by summarizing the current knowledge of their expression,possible function and pharmacological role in IBD. | Luise Aamann Else Marie Vestergaard Henning Grφnbk | 2014 | World Journal of Gastroenterology2014，20，12： | 6 |
| 2 | Development and predictive validity of the cirrhosis-associated ascites symptom scale: A cohort study of 103 patients显示文摘AIM To develop a scale of domains associated with the health-related quality-of-life(HRQOL) in patients with cirrhosis-related ascites.METHODS We initially undertook literature searches and a qualitative study in order to design a cirrhosis-associated ascites symptom(CAS) scale describing symptoms with a potential detrimental impact on health related quality of life(HRQL)(the higher the score, the worse the symptoms). Discriminatory validity was assessed in a validation cohort including cirrhotic patients with(1) tense/severe;(2) moderate/mild; or(3) no ascites(controls). Patients also completed chronic liver disease questionnaire(CLDQ) and the Euro QoL 5-Dimensions 5-Level(EQ-5D-5L) questionnaire evaluating HRQL. The relation between scale scores was analysed using Spearman correlations. RESULTS The final CAS scale included 14 items. The equivalent reliability was high(Chronbach's alpha 0.88). The validation cohort included 103 patients(72% men, mean age 62.4 years). The mean scores for each question in the CAS scale were higher for patients with severe/tense ascites than for mild/moderate ascites and controls. Compared with controls(mean = 9.9 points), the total CAS scale score was higher for severe/tense ascites(mean = 23.8 points) as well as moderate/mild ascites(mean = 18.6 points)(P < 0.001 both groups). We found a strong correlation between the total CAS and CLDQ score(rho = 0.82, P < 0.001) and a moderate correlation between the CAS and the EQ-5D-5L score(0.67, P < 0.001). CONCLUSION The CAS is a valid tool, which reflects HRQOL in patients with ascites. | Agnete Nordheim Riedel Nina Kimer Anne-Sofie Houlberg Jensen Emilie Kristine Dahl Mads Israelsen Luise Aamann Lise Lotte Gluud | 2018 | World Journal of Gastroenterology2018，24，15： | 3 |
| 3 | Regulation of MLH1 mRNA and protein expression by promoter methylation in primary colorectal cancer: a descriptive and prognostic cancer marker study显示文摘 | Lars Henrik Jensen Anders Aamann Rasmussen Lene Byriel Hidekazu Kuramochi Dorthe Gylling Crüger Jan Lindebjerg Peter V. Danenberg Anders Jakobsen Kathleen Danenberg | 2013 | Cellular Oncology2013，，5： | 2 |
| 4 | The involvement of human RECQL4in DNA double-strand break repair显示文摘 | Singh D K Karmakar P Aamann M | 2010 | Aging Cell2010，9，3： | 1 |
| 5 | The in- volvement of human RECQIA in DNA double-strand break repair显示文摘 | SINGH D K KARMAKAR P AAMANN M | 2010 | Aging Ce112010，9，3： | 1 |
| 6 | Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane 显示文摘 | Aamann M D Sorensen M M Hvitby C | 2010 | The FASEB Journal2010，24，7： | 1 |
| 7 | The role of Cockayne syndrome group B (CSB) protein in base excision repair and aging显示文摘 | Stevnsner T Muftuoglu M Aamann MD Bohr VA | 2008 | Mech Ageing Dev2008，129，78： | 1 |
| 8 | The role of Cockayne syndrome group B (CSB) protein in base excision repair and aging显示文摘 | Slevnsner T Muftuoglu M Aamann MI) | 2008 | Mech Ageing Dev2008，129，78： | 1 |
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