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| 1 | Monomethyl fumarate augments NK cell lysis of tumor cells through degranulation and the upregulation of NKp46 and CDIO7a显示文摘Dimethyl fumarate (DMF ) 是使用到对待的新药多重硬化(MS ) 病人。这里,我们在生来的杀手(NK ) 的各种各样的活动检验了 DMF 和 DMF 代谢物 monomethyl fumarate (MMF ) 的效果房间。我们证明 MMF 扩充 K562 和 RAJI 肿瘤房间的主要 CD56 +, 然而并非 CD56 −, NK 房间细胞溶解。MMF 为 24 h 在孵化以后在 CD56 +, 然而并非 CD56 −, NK 房间的表面上导致了 NKp46 表示。这效果密切通过这代谢物从这些房间在 CD56 + NK 房间和 Granzyme B 版本的正式就职的表面上与 CD107a 表示的 upregulation 被相关。anti-NKp46 抗体通过 CD56 + NK 房间禁止了 CD107a 的导致 MMF 的 upregulation 和肿瘤房间的细胞溶解。因此,这些结果是第一证明 MMF 扩充肿瘤目标房间的 CD56 + NK 房间细胞溶解,效果通过 NKp46 调停了。这新奇效果在癌症为治疗学或预防的协议建议 MMF 的使用。 | Heidi Vego Kristin L Sand Rune A Hoglund Lars-Egil Fallang Glenn Gundersen Trygve Holmoy Azzam A Maghazachi | 2016 | Cellular & Molecular Immunology2016，13，1： | 2 |
| 2 | Creep fracture of sandstones显示文摘 | CHEN Y L AZZAM R | 2007 | Theoretical and Applied Fracture Mechanics2007，47，1： | 1 |
| 3 | Reduced complexity sphere deco- ding for square QAM via a new lattice representation 显示文摘 | AZZAM L AYANOGLU E | 2007 | IEEE Globeeom2007，，12： | 1 |
| 4 | Effect of excess dietary L-valine on laying hen performance,egg quality,serum free amino acids,immune function and antioxidant enzyme activity显示文摘 | AZZAM M M DONG X Y DAI L | 2014 | British Poultry Science2014，56，1： | 1 |
| 5 | In vivo significance of ICAM-1-dependent leukocyte adhesion in early corneal angiogenesis显示文摘 | Becker MD Kruse FE Azzam L | 1999 | Invest Ophthalmol Vis Sci1999，40，3： | 1 |
| 6 | A bifunctional catalyst for the single-stage water-gas shift reactionin fuel cell applications显示文摘 | AZZAM K G BABICH L V SESHAN K | 2007 | Journal of Catalysis2007，251，1： | 1 |
| 7 | In vivo significance of ICAM- ldependent leukocvte adhesion in early corneal anyiogenesis 显示文摘 | BECKER M D KRUSE F E AZZAM L | 1999 | Invest Ophthalmol Vis Sci1999，40，： | 1 |
| 8 | Polysaccharide-oligoamine based conjugates for gene delivery显示文摘 | Azzam T Eliyahu H Shapira L | 2002 | Journal of Medicinal Chemistry2002，45，9： | 1 |
| 9 | A Novel Maximum Likelihood Decoding Algorithm for Orthogonal Space-Time Block Codes显示文摘 | Azzam L Ayanoglu E | 2009 | IEEE Trans Commun2009，57，3： | 1 |
| 10 | In vivo significance of ICAM-l-dependent leukocyte adhesion in early corneal angiogenesis显示文摘 | Becker MD Kruse FE Azzam L | 1999 | Lvest Ophthalmol Vis Sci1999，40，3： | 1 |
| 11 | Use of a simulation model to evaluate the influence of reproductive performance and management decisions on net income in beef production 显示文摘 | Werth L A Azzam M K Nielsen M K | 1991 | Journal of Animal Science1991，69，： | 1 |
| 12 | The uniaxial compressive and tensile tests of frozen saturated clay in Shanghai area显示文摘 | Chen Y L Azzam R Wang M | | 0，，1： | 1 |
| 13 | Polysaccharide-oligoamine based conjugates for gene delivery显示文摘 | Azzam T Elivahu H Shapira L | 2002 | J Med Chem2002，45，9： | 1 |
| 14 | Rapid and simple chromatographic method for the determination of diazepam and its major metabolites in human plasma and urine 显示文摘 | Azzam R M Notarianni L J Ali H M | 1998 | Journal of Chormatography B1998，708，： | 1 |
| 15 | 显示文摘 | Azzam T Eliyahu H Shapira L | 2002 | J Med Chem2002，45，： | 1 |
| 16 | Polysaccharide-oligoamine based conjugates for gene delivery 显示文摘 | Azzam T Eliyahu H Shapira L Linial M Barenholz Y Domb AJ | 2002 | Med Chern2002，45，9： | 1 |
| 17 | Polysaccharide Oligoamine Based Conjugates for Gene Delivery 显示文摘 | AZZAM T ELIYAHU H SHAPIRA L | 2002 | J Med Chem2002，45，9： | 1 |
| 18 | In vivo significance of ICAM-1 dependent leukocyte adhesion in early corneal angiogenesis显示文摘 | Becker MD Kruse FE Azzam L | 1999 | Invest Ophthalmol Vis Sci1999，40，3： | 1 |
| 19 | Achromatic Angle-insensitive Infrared Quarter-wave Retarder Based on Total Internal Reflection at the Si- SiO2 Interface 显示文摘 | Azzam R M A Spinu Cristina L | 2004 | Journal of the Optical Society of America A2004，21，10： | 1 |
| 20 | Second-generation locking mechanisms and ethylene oxide sterilization reduce tibial insert backside dam- age in total knee arthroplasty显示文摘 | Azzam M G Roy M E Whiteside L A | 2011 | J Arthroplasty2011，26，4： | 1 |
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