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| 1 | Glutamine is highly effective in preventing in vivo cobalt-induced oxidative stress in rat liver显示文摘AIM: To evaluate the in vivo effect of glutamine on cobaltgenerated oxidative stress and (HO-1) induction in rat liver.METHODS: Fasted female Wistar rats received a single injection of cobalt chloride (375 μmol/kg body weight) and then were killed at different times. Lipid peroxidation and soluble and enzymatic antioxidant defense system (reduced glutathione (GSH), catalase (CAT), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD)) were measured in liver homogenates. Ferritin and ferritin iron contents as well as heme oxygenase-1 (HO-1) activity and expression were also determined. The antioxidant properties of glutamine (Gin) were also evaluated. RESULTS: Cobalt chloride increased lipid peroxidation (50% over control values) 1 h after treatment. GSH reached a minimum at 3 h (40%) increasing thereafter. Twelve hours after CoCl2 injection, the antioxidant enzymes CAT, GSH-Px and SOD also diminished by about 30%. Heme oxygenase-1 induction was observed 6 h after treatment reaching a maximum value of 14-fold over the controls, 12 h after cobalt treatment. A 1.7-fold increase in ferritin and ferritin-bound iron 24 h after treatment were also obtained. Administration of glutamine (300 mg/kg body weight) by gavage 24 h before CoCl2 treatment entirely prevented the increase in thiobarbituric acid reactive substances (TBARS) content, the decrease in GSH levels, and partially reverted heme oxygenase-1 induction. CONCLUSION: These results suggested that a natural product such as glutamine prevents glutathione depletion and consequently heme oxygenase induction. | Soledad Gonzales Ariel H.Polizio María A.Erario María L.Tomaro | 2005 | World Journal of Gastroenterology2005，11，23： | 16 |
| 2 | Hepatic encephalopathy: Ever closer to its big bang显示文摘Hepatic encephalopathy(HE) is a neuropsychiatric disorder that commonly complicates the course of patients with liver disease. Despite the fact that the syndrome was probably first recognized hundreds of years ago, the exact pathogenesis still remains unclear. Minimal hepatic encephalopathy(MHE) is the earliest form of HE and is estimated to affect more that 75% of patients with liver cirrhosis. It is characterized by cognitive impairment predominantly attention, reactiveness and integrative function with very subtle clinical manifestations. The development of MHE is associated with worsen in driving skills, daily activities and the increase of overall mortality. Skeletal muscle has the ability to shift from ammonia producer to ammonia detoxifying organ. Due to its large size, becomes the main ammonia detoxifying organ in case of chronic liver failure and muscular glutaminesynthase becomes important due to the failing liver and brain metabolic activity. Gut is the major glutamine consumer and ammonia producer organ in the body. Hepatocellular dysfunction due to liver disease, results in an impaired clearance of ammonium and in its interorgan trafficking. Intestinal bacteria, can also represent an extra source of ammonia production and in cirrhosis, small intestinal bacterial overgrowth and symbiosis can be observed. In the study of HE, to get close to MHE is to get closer to its big bang; and from here, to travel less transited roads such as skeletal muscle and intestine, is to go even closer. The aim of this editorial is to expose this road for further and deeper work. | Pablo A Souto Ariel R Marcotegui Lisandro Orbea Juan Skerl Juan Carlos Perazzo | 2016 | World Journal of Gastroenterology2016，22，42： | 6 |
| 3 | 1-Methylcyclopropene (1-MCP) delays senescence, maintains quality and reduces browning of non-climacteric eggplant ( Solanum melongena L.) fruit显示文摘 | Juan F. Massolo Analía Concellón Alicia R. Chaves Ariel R. Vicente | 2010 | Postharvest Biology and Technology2010，，1： | 2 |
| 4 | 非酒精性脂肪性肝病和非酒精性脂肪性肝炎的无创性诊断显示文摘非酒精性脂肪性肝病(NAFLD)在美国和世界上许多其他地区都是最常见的慢性肝病,其患病率持续上升,目前美国约1/4的成人和10%的儿童患NAFLD。NAFLD包括多种疾病状态,从通常呈良性、非进展性临床过程的单纯性脂肪肝直至更为严重的、可进展为肝硬化和终末期肝病的非酒精性脂肪性肝炎(NASH)。目前,NASH的诊断依赖于创伤性肝活检,而肝活检存在取样和读片误差的缺陷。NASH的临床危险因素包括糖尿病和代谢综合征,但这些因素本身不足以预测NASH。常规肝酶水平预测可靠性低,新型血浆肝细胞死亡标记物单独或与临床危险因素联合今后可能成为无创性诊断工具。本文对无创性诊断工具在鉴别单纯性脂肪肝与NASH以及确定肝纤维化的存在及其范围中的作用作一概述。 | Leon A ADAMS Ariel E FELDSTEIN 张海燕 钱本余 马雄 | 2011 | 胃肠病学2011，16，3： | 2 |
| 5 | Anammox sludge immobilized in polyvinyl alcohol (PVA) cryogel carriers显示文摘 | Magri Albert Vanotti Matias B SzOgi Ariel A | 2012 | Biore- sour Teehnol2012，114，： | 1 |
| 6 | TNF-alpha and IL-8 regulate the expression and function of CD44 varian proteins in human colon carcinoma cells显示文摘 | Barshishat M Ariel A Cahalon L | 2002 | Clin Exp Metastasis2002，19，4： | 1 |
| 7 | Evaluation of political risk in a shipping project 显示文摘 | ARIEL A | 1990 | Maritime Policy and Management1990，17，1： | 1 |
| 8 | Genome-based bioinformatic selection of chromosomal Bacillus anthracis putative vaccine candidates coupled with proteomic identification of surface-associated antigens 显示文摘 | Ariel N Zvi A Makarova K S | 2003 | Infect Immun2003，71，8： | 1 |
| 9 | Monocyte chemotaetic protein-1 concentration in peritoneal fluid of women with endometriosisand its modulation of expression in mesothelial cells 显示文摘 | Ariel A Oral E Attar E | 1997 | Fertil Steril1997，67，6： | 1 |
| 10 | Development of environmentally superior treatment system to replace anaerobic swine lagoons in the USA 显示文摘 | Matias B Ariel A Patrick G | 2007 | Bioresource Technology2007，98，17： | 1 |
| 11 | Search for potential vaccine candidate open reading frames in the Bacillus anthracis virulence plasmid pxol : in silico and in vitro screening 显示文摘 | Ariel N Zvi A Grosfeld H | 2002 | Infect Im- mun2002，70，12： | 1 |
| 12 | Effect of heat treatment on strawberry fruit damage and oxidative metabolism during storage显示文摘 | Ariel R V Gustavo A M Alicia R C | 2006 | Postharvest Biolog'' and Teclmolo:v2006，40，： | 1 |
| 13 | Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac per- formance, or the response to volume infusion in normal subjects显示文摘 | Kumar A Ariel R Bunnell E | 2004 | Grit Care Med2004，32，1： | 1 |
| 14 | Whole genome identification of Mycobacterium tuberculosis vaccine candidates by comprehensive data mining and bioinformatic analyses 显示文摘 | Zvi A Ariel N Fulkerson J | 2008 | BMC Med Genomics2008，1，1： | 1 |
| 15 | Genome-based bioinformatics selection of chromosomal Bacillus onthracis prtative vaccine candidates coupled with proteomic identification of surface-associated antigens显示文摘 | Ariel N Zvi A Makarova KS | 2003 | Infection Immunity2003，71，8： | 1 |
| 16 | TNF alpha and IL28 egulate the expression and function of CD44 variant proteins in human coloncarclnoma cells显示文摘 | Barshishat M Ariel A Cahalon L | 2002 | Clin Exp Metastasis2002，19，4： | 1 |
| 17 | Proton pump inhibitor omeprazole use is associated with low bone mineral density in maintenance haemodialysis patients 显示文摘 | Kirkpantur A Ahun B Ariel M et at | 2009 | Inter J Clin Prae2009，63，2： | 1 |
| 18 | Minimum-cost canal cr- oss section显示文摘 | Ghazaw Y Salem Ariel A S Osama K | 2000 | Alexandria Engineering Journal2000，39，1： | 1 |
| 19 | Abnormalities of lipoprotein concentra- tions in obstructive sleep apnea are related to insulin resistance 显示文摘 | Liu A Cardell J Ariel D | 2015 | Sleep2015，38，5： | 1 |
| 20 | QoS routing in networks with inaccurate information:Theory and algorithms显示文摘 | Roch A Guerin Ariel Orda | 1999 | IEEE/ACM Transctions Networking1999，7，3： | 1 |
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